PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
BACKGROUND: Non-alcoholic fatty liver diseases (NAFLD) is the hepatic manifestation of metabolic syndrome. The insulin resistance causes NAFLD through fat accumulation in liver which is derived from the release of free fatty acid. Nowadays, the treatment modality is still very limited. Some previous...
| Main Authors: | , |
|---|---|
| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
|
| Subjects: |
| _version_ | 1826048979740131328 |
|---|---|
| author | , Wawan Triharjanto , Prof. dr. Siti Nurdjanah, M.Kes, SpPD, KGEH(K) |
| author_facet | , Wawan Triharjanto , Prof. dr. Siti Nurdjanah, M.Kes, SpPD, KGEH(K) |
| author_sort | , Wawan Triharjanto |
| collection | UGM |
| description | BACKGROUND: Non-alcoholic fatty liver diseases (NAFLD) is the hepatic
manifestation of metabolic syndrome. The insulin resistance causes NAFLD
through fat accumulation in liver which is derived from the release of free
fatty acid. Nowadays, the treatment modality is still very limited. Some
previous studies have reported that Metformin and Valsartan give an
improvement towards the insulin resistance and liver histology. These
outcomes are related to the increased serum adiponectin levels. Adiponectin
has important roles in the insulin sensitivity, inflammation, lipid metabolism,
and atherogenesis. The aim of this research is to understand the effect of
Metformin and Valsartan on adiponectin levels in metabolic syndrome
patients with NAFLD.
METHODS : this is an experimental study using before and after design. The
research was done at Endocrinology Division polyclinic of Department of
Internal Medicine in Central General Hospital Dr. Sardjito Yogyakarta. The
subjects of this research were the patients who met the metabolic syndrome
criterias according to IDF 2005, hypertension, and NAFLD. Subjects were
treated with Metformin and Valsartan for 12 weeks. The adiponectin levels
was analyzed before and after treatment. The average of the increased
adiponectin levels was analyzed by using paired t-test if the data was
normally distributed and Wilcoxon if the data was not normally distributed.
The significance of p<0,05 was assumed as statistically significant.
RESULT : there were 15 subjects in this research and all were able to finnish the
research process. In this study there is statistically significant increased
adiponectin levels after 12 weeks treatment Metformin and Valsartan
(p=0,001).
CONCLUSION: the result of this study suggests that there is statistically
significant increased adiponectin levels after 12 weeks treatment with
Metformin and Valsartan. |
| first_indexed | 2024-03-13T23:38:36Z |
| format | Thesis |
| id | oai:generic.eprints.org:133216 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:38:36Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1332162016-03-04T08:17:45Z https://repository.ugm.ac.id/133216/ PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) , Wawan Triharjanto , Prof. dr. Siti Nurdjanah, M.Kes, SpPD, KGEH(K) ETD BACKGROUND: Non-alcoholic fatty liver diseases (NAFLD) is the hepatic manifestation of metabolic syndrome. The insulin resistance causes NAFLD through fat accumulation in liver which is derived from the release of free fatty acid. Nowadays, the treatment modality is still very limited. Some previous studies have reported that Metformin and Valsartan give an improvement towards the insulin resistance and liver histology. These outcomes are related to the increased serum adiponectin levels. Adiponectin has important roles in the insulin sensitivity, inflammation, lipid metabolism, and atherogenesis. The aim of this research is to understand the effect of Metformin and Valsartan on adiponectin levels in metabolic syndrome patients with NAFLD. METHODS : this is an experimental study using before and after design. The research was done at Endocrinology Division polyclinic of Department of Internal Medicine in Central General Hospital Dr. Sardjito Yogyakarta. The subjects of this research were the patients who met the metabolic syndrome criterias according to IDF 2005, hypertension, and NAFLD. Subjects were treated with Metformin and Valsartan for 12 weeks. The adiponectin levels was analyzed before and after treatment. The average of the increased adiponectin levels was analyzed by using paired t-test if the data was normally distributed and Wilcoxon if the data was not normally distributed. The significance of p<0,05 was assumed as statistically significant. RESULT : there were 15 subjects in this research and all were able to finnish the research process. In this study there is statistically significant increased adiponectin levels after 12 weeks treatment Metformin and Valsartan (p=0,001). CONCLUSION: the result of this study suggests that there is statistically significant increased adiponectin levels after 12 weeks treatment with Metformin and Valsartan. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Wawan Triharjanto and , Prof. dr. Siti Nurdjanah, M.Kes, SpPD, KGEH(K) (2014) PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD). UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73777 |
| spellingShingle | ETD , Wawan Triharjanto , Prof. dr. Siti Nurdjanah, M.Kes, SpPD, KGEH(K) PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) |
| title | PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) |
| title_full | PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) |
| title_fullStr | PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) |
| title_full_unstemmed | PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) |
| title_short | PENGARUH PEMBERIAN METFORMIN DAN VALSARTAN TERHADAP KADAR ADIPONEKTIN PADA PENDERITA SINDROMA METABOLIK DENGAN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) |
| title_sort | pengaruh pemberian metformin dan valsartan terhadap kadar adiponektin pada penderita sindroma metabolik dengan non alcoholic fatty liver disease nafld |
| topic | ETD |
| work_keys_str_mv | AT wawantriharjanto pengaruhpemberianmetformindanvalsartanterhadapkadaradiponektinpadapenderitasindromametabolikdengannonalcoholicfattyliverdiseasenafld AT profdrsitinurdjanahmkessppdkgehk pengaruhpemberianmetformindanvalsartanterhadapkadaradiponektinpadapenderitasindromametabolikdengannonalcoholicfattyliverdiseasenafld |