FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb) DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr) MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK
The previous study has shown that extract combination of C. XanthorrhizaRoxb and G. Procumbens, Lour. Merr. in 75:25 ratio decreased significantly cholesterol blood level in rat. However, due to the extract�s solubilities problem, the extracts were developed in the form of SNEDDS (self-nanoemulsif...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1826048991897321472 |
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| author | , Aulia Ul Hafizah , Prof. Dr. Zullies Ikawati, Apt |
| author_facet | , Aulia Ul Hafizah , Prof. Dr. Zullies Ikawati, Apt |
| author_sort | , Aulia Ul Hafizah |
| collection | UGM |
| description | The previous study has shown that extract combination of C. XanthorrhizaRoxb
and G. Procumbens, Lour. Merr. in 75:25 ratio decreased significantly cholesterol
blood level in rat. However, due to the extract�s solubilities problem, the extracts
were developed in the form of SNEDDS (self-nanoemulsifying drug delivery
system). The purposes of this study were to formulate the extracts combination in
form of SNEDD using virgin coconut oil as the oil phase and to evaluate the
cholesterol lowering activity of the optimum formula obtained.
The emulsification time, extract loading, and anti-cholesterol activity test were
used as parameters for determining of the SNEDDS optimum formula for Curcuma
xanthorrhiza Roxb and GynuraProcumbens (lour) Merr extracts combination. The
anti-cholesterol activity test was carried out using four male Wistar rats which were
that randomly selected. Blood cholesterol levels were checked on day 0, 30, 60, 67,
70. The ANOVA statistical analysis were used to determine the difference between
the data blood cholesterol level.
The results showed that the optimum formula, i. e |
| first_indexed | 2024-03-13T23:38:48Z |
| format | Thesis |
| id | oai:generic.eprints.org:133277 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:38:48Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1332772016-03-04T07:53:11Z https://repository.ugm.ac.id/133277/ FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb) DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr) MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK , Aulia Ul Hafizah , Prof. Dr. Zullies Ikawati, Apt ETD The previous study has shown that extract combination of C. XanthorrhizaRoxb and G. Procumbens, Lour. Merr. in 75:25 ratio decreased significantly cholesterol blood level in rat. However, due to the extract�s solubilities problem, the extracts were developed in the form of SNEDDS (self-nanoemulsifying drug delivery system). The purposes of this study were to formulate the extracts combination in form of SNEDD using virgin coconut oil as the oil phase and to evaluate the cholesterol lowering activity of the optimum formula obtained. The emulsification time, extract loading, and anti-cholesterol activity test were used as parameters for determining of the SNEDDS optimum formula for Curcuma xanthorrhiza Roxb and GynuraProcumbens (lour) Merr extracts combination. The anti-cholesterol activity test was carried out using four male Wistar rats which were that randomly selected. Blood cholesterol levels were checked on day 0, 30, 60, 67, 70. The ANOVA statistical analysis were used to determine the difference between the data blood cholesterol level. The results showed that the optimum formula, i. e [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Aulia Ul Hafizah and , Prof. Dr. Zullies Ikawati, Apt (2014) FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb) DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr) MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73850 |
| spellingShingle | ETD , Aulia Ul Hafizah , Prof. Dr. Zullies Ikawati, Apt FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb) DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr) MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK |
| title | FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb)
DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr)
MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK |
| title_full | FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb)
DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr)
MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK |
| title_fullStr | FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb)
DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr)
MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK |
| title_full_unstemmed | FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb)
DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr)
MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK |
| title_short | FORMULASI DAN UJI AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) SEBAGAI ANTI-HIPERKOLESTEROL DARI KOMBINASI EKSTRAK TEMULAWAK (Curcuma xanthorrhiza Roxb)
DAN DAUN SAMBUNG NYAWA (Gynura procumbent (Lour)Merr)
MENGGUNAKAN VIRGIN COCONUT OIL SEBAGAI FASE MINYAK |
| title_sort | formulasi dan uji aktivitas self nanoemulsifying drug delivery system snedds sebagai anti hiperkolesterol dari kombinasi ekstrak temulawak curcuma xanthorrhiza roxb dan daun sambung nyawa gynura procumbent lour merr menggunakan virgin coconut oil sebagai fase minyak |
| topic | ETD |
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