HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010
Background : Breast cancer emerges as the highest incident cancer in Indonesia. Mortality of breast cancer reaches up to 19,750 of 48,998 cases (40.31%) in 2012. Locoregional recurrence usually develops 2-3 year after operation. Recurrence incidence rate in Indonesia is very high affecting 20.2% of...
| Main Authors: | , |
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1797035973850169344 |
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| author | , Nanang Widodo , dr. Kunta Setiaji, Sp.B (K) Onk |
| author_facet | , Nanang Widodo , dr. Kunta Setiaji, Sp.B (K) Onk |
| author_sort | , Nanang Widodo |
| collection | UGM |
| description | Background : Breast cancer emerges as the highest incident cancer in Indonesia.
Mortality of breast cancer reaches up to 19,750 of 48,998 cases (40.31%) in 2012.
Locoregional recurrence usually develops 2-3 year after operation. Recurrence
incidence rate in Indonesia is very high affecting 20.2% of total breast cancer
cases. Several factors are identified to play a role in the breast cancer recurrence,
including age, tumor size, tumor stadium, lymph nodes status, histopathology
grade, estrogen receptor, progesterone receptor, and HER-2/neu
immunohistochemical subtypes.
Objective: To identify the most recent variables involved in the locoregional
recurrence of operable breast cancer after modified radical mastectomy and
adjuvant chemotherapy.
Subject: Patients with operable breast cancer who underwent a modified radical
mastectomy in Dr Sardjito hospital on January until December 2010 and met the
inclusion criteria.
Methods: We used descriptive non-experimental study with a retrospective
cohort design involving 109 patients with operable breast cancer treated in Dr
Sardjito hospital Januari-December 2010. Chi-square test and multivariate
analysis with logistic regression were used to determine clinicopathologic factors
involved in the high recurrence rate of breast cancer in Indonesia.
Results: In our cohort, we identified locoregional recurrence in 18 of 109 breast
cancer patients (16.51%). Clinicopathologic factors that significantly affect the
incidence of recurrence were tumor stadium (Breast cancer stadium IIIB vs IIIA,
p=0,006, OR 2,62). Tumor grade (grade 1 vs grade 3, p=0,039, OR 3,6), and
Her2/neu (Positive vs negative, p=0,037, OR 0,22). In addition, subtype of breast
cancer using immunohistochemitry showed that triple negative increased
recurrence rate in comparison to luminal B (p=0,009, OR 4,2). Multivariate
analysis using logistic regression showed that immunohistochemical subtype was
the most dominant factor influencing recurrence rate (p=0,041), particulary in
triple negative breast cancer (p=0,047).
Conclusion: In our study, clinicopathological variables affecting locoregional
recurrence of breast cancer were tumor stadium, histopathological grading, and
HER-2/neu immunohistochemical subtypes. The most dominant factor affecting
the incidence of recurrence was subtype of immunohistochemistry (triple
negative |
| first_indexed | 2024-03-13T23:38:50Z |
| format | Thesis |
| id | oai:generic.eprints.org:133292 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:38:50Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1332922016-03-04T08:04:57Z https://repository.ugm.ac.id/133292/ HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010 , Nanang Widodo , dr. Kunta Setiaji, Sp.B (K) Onk ETD Background : Breast cancer emerges as the highest incident cancer in Indonesia. Mortality of breast cancer reaches up to 19,750 of 48,998 cases (40.31%) in 2012. Locoregional recurrence usually develops 2-3 year after operation. Recurrence incidence rate in Indonesia is very high affecting 20.2% of total breast cancer cases. Several factors are identified to play a role in the breast cancer recurrence, including age, tumor size, tumor stadium, lymph nodes status, histopathology grade, estrogen receptor, progesterone receptor, and HER-2/neu immunohistochemical subtypes. Objective: To identify the most recent variables involved in the locoregional recurrence of operable breast cancer after modified radical mastectomy and adjuvant chemotherapy. Subject: Patients with operable breast cancer who underwent a modified radical mastectomy in Dr Sardjito hospital on January until December 2010 and met the inclusion criteria. Methods: We used descriptive non-experimental study with a retrospective cohort design involving 109 patients with operable breast cancer treated in Dr Sardjito hospital Januari-December 2010. Chi-square test and multivariate analysis with logistic regression were used to determine clinicopathologic factors involved in the high recurrence rate of breast cancer in Indonesia. Results: In our cohort, we identified locoregional recurrence in 18 of 109 breast cancer patients (16.51%). Clinicopathologic factors that significantly affect the incidence of recurrence were tumor stadium (Breast cancer stadium IIIB vs IIIA, p=0,006, OR 2,62). Tumor grade (grade 1 vs grade 3, p=0,039, OR 3,6), and Her2/neu (Positive vs negative, p=0,037, OR 0,22). In addition, subtype of breast cancer using immunohistochemitry showed that triple negative increased recurrence rate in comparison to luminal B (p=0,009, OR 4,2). Multivariate analysis using logistic regression showed that immunohistochemical subtype was the most dominant factor influencing recurrence rate (p=0,041), particulary in triple negative breast cancer (p=0,047). Conclusion: In our study, clinicopathological variables affecting locoregional recurrence of breast cancer were tumor stadium, histopathological grading, and HER-2/neu immunohistochemical subtypes. The most dominant factor affecting the incidence of recurrence was subtype of immunohistochemistry (triple negative [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Nanang Widodo and , dr. Kunta Setiaji, Sp.B (K) Onk (2014) HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73871 |
| spellingShingle | ETD , Nanang Widodo , dr. Kunta Setiaji, Sp.B (K) Onk HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010 |
| title | HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010 |
| title_full | HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010 |
| title_fullStr | HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010 |
| title_full_unstemmed | HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010 |
| title_short | HUBUNGAN ANTARA STATUS KLINIKOPATOLOGI PADA PENDERITA KANKER PAYUDARA OPERABEL YANG MENJALANI OPERASI MASTEKTOMI RADIKAL MODIFIKASI DENGAN REKURENSI LOKOREGIONAL DI RSUP Dr. SARDJITO 2010 |
| title_sort | hubungan antara status klinikopatologi pada penderita kanker payudara operabel yang menjalani operasi mastektomi radikal modifikasi dengan rekurensi lokoregional di rsup dr sardjito 2010 |
| topic | ETD |
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