PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA
The releasing kinetic of curcumin in chitosan-carboxymethyl cellulose nanoparticles crosslinked with glutaraldehyde has been studied. Identification of functional groups was determined by Fourier Transform Infrared (FTIR) spectrophotometry method. The crystallinity characteris...
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Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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author | , PRAPTANTI SINUNG A.N , Dr. Dwi Siswanta, M.Eng. |
author_facet | , PRAPTANTI SINUNG A.N , Dr. Dwi Siswanta, M.Eng. |
author_sort | , PRAPTANTI SINUNG A.N |
collection | UGM |
description | The releasing kinetic of curcumin in chitosan-carboxymethyl cellulose
nanoparticles crosslinked with glutaraldehyde has been studied. Identification of
functional groups was determined by Fourier Transform Infrared (FTIR)
spectrophotometry method. The crystallinity characteristic was tested by X-Ray
Diffraction (XRD). Particle size determination was performed using Transmission
Electron Microscopy (TEM), whereas the morphological characterization was
tested by Scanning Electron Microscopy (SEM). Studyof curcumin release was
determined by UV-Vis spectrophotometer. In this research, the effects of chitosan,
KMS, and glutaraldehyde (GA) concentration were studied. Kinetics model of
zero order, first order, Higuchi, and Korsmeyer-Peppas were used to test the
kinetics of curcumin release.
The results showed that the electrostatic interaction between the amine
group with a carboxyl group can cause a shift in the uptake of chitosan-KMS-GA
nanoparticles at wave number 1589 cm
-1
. Nanoparticles have a size of ±70 nm.
The composition of chitosan-KMS-GA nanoparticles concentration obtained at
the optimum ratio 3:1:0.8. Model equation of curcumin release followed
Korsmeyer-Peppas kinetics with the Fickian diffusion mechanism. Curcumin
release of 53.82% as much happened for 5 hours. |
first_indexed | 2024-03-13T23:39:53Z |
format | Thesis |
id | oai:generic.eprints.org:133630 |
institution | Universiti Gadjah Mada |
last_indexed | 2024-03-13T23:39:53Z |
publishDate | 2014 |
publisher | [Yogyakarta] : Universitas Gadjah Mada |
record_format | dspace |
spelling | oai:generic.eprints.org:1336302016-03-04T08:06:34Z https://repository.ugm.ac.id/133630/ PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA , PRAPTANTI SINUNG A.N , Dr. Dwi Siswanta, M.Eng. ETD The releasing kinetic of curcumin in chitosan-carboxymethyl cellulose nanoparticles crosslinked with glutaraldehyde has been studied. Identification of functional groups was determined by Fourier Transform Infrared (FTIR) spectrophotometry method. The crystallinity characteristic was tested by X-Ray Diffraction (XRD). Particle size determination was performed using Transmission Electron Microscopy (TEM), whereas the morphological characterization was tested by Scanning Electron Microscopy (SEM). Studyof curcumin release was determined by UV-Vis spectrophotometer. In this research, the effects of chitosan, KMS, and glutaraldehyde (GA) concentration were studied. Kinetics model of zero order, first order, Higuchi, and Korsmeyer-Peppas were used to test the kinetics of curcumin release. The results showed that the electrostatic interaction between the amine group with a carboxyl group can cause a shift in the uptake of chitosan-KMS-GA nanoparticles at wave number 1589 cm -1 . Nanoparticles have a size of ±70 nm. The composition of chitosan-KMS-GA nanoparticles concentration obtained at the optimum ratio 3:1:0.8. Model equation of curcumin release followed Korsmeyer-Peppas kinetics with the Fickian diffusion mechanism. Curcumin release of 53.82% as much happened for 5 hours. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , PRAPTANTI SINUNG A.N and , Dr. Dwi Siswanta, M.Eng. (2014) PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74351 |
spellingShingle | ETD , PRAPTANTI SINUNG A.N , Dr. Dwi Siswanta, M.Eng. PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA |
title | PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA |
title_full | PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA |
title_fullStr | PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA |
title_full_unstemmed | PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA |
title_short | PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA |
title_sort | pelepasan kurkumin dari nanopartikel kitosan karboksimetil selulosa glutaraldehida |
topic | ETD |
work_keys_str_mv | AT praptantisinungan pelepasankurkumindarinanopartikelkitosankarboksimetilselulosaglutaraldehida AT drdwisiswantameng pelepasankurkumindarinanopartikelkitosankarboksimetilselulosaglutaraldehida |