PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA

The releasing kinetic of curcumin in chitosan-carboxymethyl cellulose nanoparticles crosslinked with glutaraldehyde has been studied. Identification of functional groups was determined by Fourier Transform Infrared (FTIR) spectrophotometry method. The crystallinity characteris...

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Main Authors: , PRAPTANTI SINUNG A.N, , Dr. Dwi Siswanta, M.Eng.
Format: Thesis
Published: [Yogyakarta] : Universitas Gadjah Mada 2014
Subjects:
ETD
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author , PRAPTANTI SINUNG A.N
, Dr. Dwi Siswanta, M.Eng.
author_facet , PRAPTANTI SINUNG A.N
, Dr. Dwi Siswanta, M.Eng.
author_sort , PRAPTANTI SINUNG A.N
collection UGM
description The releasing kinetic of curcumin in chitosan-carboxymethyl cellulose nanoparticles crosslinked with glutaraldehyde has been studied. Identification of functional groups was determined by Fourier Transform Infrared (FTIR) spectrophotometry method. The crystallinity characteristic was tested by X-Ray Diffraction (XRD). Particle size determination was performed using Transmission Electron Microscopy (TEM), whereas the morphological characterization was tested by Scanning Electron Microscopy (SEM). Studyof curcumin release was determined by UV-Vis spectrophotometer. In this research, the effects of chitosan, KMS, and glutaraldehyde (GA) concentration were studied. Kinetics model of zero order, first order, Higuchi, and Korsmeyer-Peppas were used to test the kinetics of curcumin release. The results showed that the electrostatic interaction between the amine group with a carboxyl group can cause a shift in the uptake of chitosan-KMS-GA nanoparticles at wave number 1589 cm -1 . Nanoparticles have a size of ±70 nm. The composition of chitosan-KMS-GA nanoparticles concentration obtained at the optimum ratio 3:1:0.8. Model equation of curcumin release followed Korsmeyer-Peppas kinetics with the Fickian diffusion mechanism. Curcumin release of 53.82% as much happened for 5 hours.
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spelling oai:generic.eprints.org:1336302016-03-04T08:06:34Z https://repository.ugm.ac.id/133630/ PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA , PRAPTANTI SINUNG A.N , Dr. Dwi Siswanta, M.Eng. ETD The releasing kinetic of curcumin in chitosan-carboxymethyl cellulose nanoparticles crosslinked with glutaraldehyde has been studied. Identification of functional groups was determined by Fourier Transform Infrared (FTIR) spectrophotometry method. The crystallinity characteristic was tested by X-Ray Diffraction (XRD). Particle size determination was performed using Transmission Electron Microscopy (TEM), whereas the morphological characterization was tested by Scanning Electron Microscopy (SEM). Studyof curcumin release was determined by UV-Vis spectrophotometer. In this research, the effects of chitosan, KMS, and glutaraldehyde (GA) concentration were studied. Kinetics model of zero order, first order, Higuchi, and Korsmeyer-Peppas were used to test the kinetics of curcumin release. The results showed that the electrostatic interaction between the amine group with a carboxyl group can cause a shift in the uptake of chitosan-KMS-GA nanoparticles at wave number 1589 cm -1 . Nanoparticles have a size of ±70 nm. The composition of chitosan-KMS-GA nanoparticles concentration obtained at the optimum ratio 3:1:0.8. Model equation of curcumin release followed Korsmeyer-Peppas kinetics with the Fickian diffusion mechanism. Curcumin release of 53.82% as much happened for 5 hours. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , PRAPTANTI SINUNG A.N and , Dr. Dwi Siswanta, M.Eng. (2014) PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74351
spellingShingle ETD
, PRAPTANTI SINUNG A.N
, Dr. Dwi Siswanta, M.Eng.
PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA
title PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA
title_full PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA
title_fullStr PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA
title_full_unstemmed PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA
title_short PELEPASAN KURKUMIN DARI NANOPARTIKEL KITOSAN-KARBOKSIMETIL SELULOSA-GLUTARALDEHIDA
title_sort pelepasan kurkumin dari nanopartikel kitosan karboksimetil selulosa glutaraldehida
topic ETD
work_keys_str_mv AT praptantisinungan pelepasankurkumindarinanopartikelkitosankarboksimetilselulosaglutaraldehida
AT drdwisiswantameng pelepasankurkumindarinanopartikelkitosankarboksimetilselulosaglutaraldehida