TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT

Severe traumatic brain injury is a primary cause of morbidity and mortality in the world�s adult population. Several factors take parts in mortality in severe traumatic brain injury. One of them is thrombocytopenia. There is no such study about thrombocytopenia as a predictor of mortality in sever...

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Main Authors: , Tis'a Callosum, , dr. Indarwati Setyaningsih, Sp.S(K).
Format: Thesis
Published: [Yogyakarta] : Universitas Gadjah Mada 2014
Subjects:
ETD
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author , Tis'a Callosum
, dr. Indarwati Setyaningsih, Sp.S(K).
author_facet , Tis'a Callosum
, dr. Indarwati Setyaningsih, Sp.S(K).
author_sort , Tis'a Callosum
collection UGM
description Severe traumatic brain injury is a primary cause of morbidity and mortality in the world�s adult population. Several factors take parts in mortality in severe traumatic brain injury. One of them is thrombocytopenia. There is no such study about thrombocytopenia as a predictor of mortality in severe traumatic brain injury in Indonesia. This study aims at identifying thrombocytopenia as a predictor of mortality in severe traumatic brain injury. This study employs retrospective cohort method. Subjects of this study were collected from the medical records of inpatient care RSUP Sardjito from January 1st, 2011 to December 31st, 2012 using the method codes of S06.4, S06.5, S06.6, S06.7 and S06.8. Data was analyzed with Chi-square test, bivariate analysis, multivariate analysis, and logistic regression. Survival was analyzed by Kaplan Meier estimator. Eighty seven subjects satisfied the inclusion and exclusion criteria. Of that number, 43 had thrombocytopenia and 44 had normothrombocyte. Twenty six patients with thrombocytopenia died. In normothrombocyte group, 13 patients died. Thrombocytopenia is the statistically significant predictor of mortality in severe traumatic brain injury (p=0,004) in bivariate analysis, with RR 2.047 (95% CI 1.221- 3.43). Other statistically significant predictors of mortality in severe traumatic brain injury are Glasgow Coma Scale (GCS) score, hypertension, hypoalbumin, hyperglycemia, presence of subarachnoid hemorrhage (SAH) and intraventricular hemorrhage (IVH). Results of multivariate analysis suggest that thrombocytopenia is not an independent predictor of mortality in severe traumatic brain injury (p=0.119), with RR 2.582 (95% CI 0.783-8.512). Other statistically significant variables as the independent predictor of mortality in multivariate analysis in severe traumatic brain injury are GCS score, hypoalbumin and presence of SAH. It is concluded that thrombocytopenia is a non-independent predictor of mortality in severe traumatic brain injury. Key words : thrombocytopenia - severe traumatic brain injury - predictor - mortality
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spelling oai:generic.eprints.org:1338412016-03-04T08:15:52Z https://repository.ugm.ac.id/133841/ TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT , Tis'a Callosum , dr. Indarwati Setyaningsih, Sp.S(K). ETD Severe traumatic brain injury is a primary cause of morbidity and mortality in the world�s adult population. Several factors take parts in mortality in severe traumatic brain injury. One of them is thrombocytopenia. There is no such study about thrombocytopenia as a predictor of mortality in severe traumatic brain injury in Indonesia. This study aims at identifying thrombocytopenia as a predictor of mortality in severe traumatic brain injury. This study employs retrospective cohort method. Subjects of this study were collected from the medical records of inpatient care RSUP Sardjito from January 1st, 2011 to December 31st, 2012 using the method codes of S06.4, S06.5, S06.6, S06.7 and S06.8. Data was analyzed with Chi-square test, bivariate analysis, multivariate analysis, and logistic regression. Survival was analyzed by Kaplan Meier estimator. Eighty seven subjects satisfied the inclusion and exclusion criteria. Of that number, 43 had thrombocytopenia and 44 had normothrombocyte. Twenty six patients with thrombocytopenia died. In normothrombocyte group, 13 patients died. Thrombocytopenia is the statistically significant predictor of mortality in severe traumatic brain injury (p=0,004) in bivariate analysis, with RR 2.047 (95% CI 1.221- 3.43). Other statistically significant predictors of mortality in severe traumatic brain injury are Glasgow Coma Scale (GCS) score, hypertension, hypoalbumin, hyperglycemia, presence of subarachnoid hemorrhage (SAH) and intraventricular hemorrhage (IVH). Results of multivariate analysis suggest that thrombocytopenia is not an independent predictor of mortality in severe traumatic brain injury (p=0.119), with RR 2.582 (95% CI 0.783-8.512). Other statistically significant variables as the independent predictor of mortality in multivariate analysis in severe traumatic brain injury are GCS score, hypoalbumin and presence of SAH. It is concluded that thrombocytopenia is a non-independent predictor of mortality in severe traumatic brain injury. Key words : thrombocytopenia - severe traumatic brain injury - predictor - mortality [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Tis'a Callosum and , dr. Indarwati Setyaningsih, Sp.S(K). (2014) TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74700
spellingShingle ETD
, Tis'a Callosum
, dr. Indarwati Setyaningsih, Sp.S(K).
TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT
title TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT
title_full TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT
title_fullStr TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT
title_full_unstemmed TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT
title_short TROMBOSITOPENIA SEBAGAI PREDIKTOR KEMATIAN CEDERA KEPALA BERAT
title_sort trombositopenia sebagai prediktor kematian cedera kepala berat
topic ETD
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AT drindarwatisetyaningsihspsk trombositopeniasebagaiprediktorkematiancederakepalaberat