| Summary: | Severe traumatic brain injury is still the leading cause of morbidity and mortality in adult
world population. There are many factors that contribute mortality in patients with severe
traumatic brain injury, one of them is hyponatremia. The study of hyponatremia as a predictor of
mortality in patient with severe traumatic brain injury in Indonesia has not been done yet. The
objective of this study is to assess hyponatremia as a predictor of mortality in patients with
severe traumatic brain injury.
The method of this study was casus control. Data were collected from medical records of
patients hospitalized in Sardjito Hospital Yogyakarta from Oktober, 1st 2012 to Oktober, 31st
2013, with code of diagnosis were S06.4, S06.5, S06.6, S06.7 dan S06.8. We analysed the data
using chi-square test in bivariate analysis followed by logistic regression in multivariate analysis.
Total subjects that match to the inclusion and exclusion criteria were 102 patients.
Subjects were divided into 2 groups: 51 subjects as casus group and 51 subjects as control group.
There were 15 subjects hyponatremia in casus group and 51 subjects non hyponatremia in
control group. Hyponatremia was statistically significant as a predictor of mortality in patients
with severe traumatic brain injury (p=0,03) with OR 3,909 (95% CI 1,031-14,827) in bivariate
analysis. The other variables that also statistically significant as a predictor of mortality in
patients with severe traumatic brain injury were Glasgow Coma Scale (GCS) score, leukositosis,
hypoalbuminemia, hyperglycemia, presence of intracranial lesion. Hyponatremia was an
independent predictor of mortality in patients with severe traumatic brain injury (p=0,03), with
OR 8,956 (95% CI 1,230-65,202) in multivariate analysis. The other variables that also
statistically significant as an independent predictor of mortality in patients with severe traumatic
brain injury were GCS score, leukositosis and presence intracranial lesion. As the conclusion of
this study, hyponatremia is an independent predictor of mortality in patients with severe
traumatic brain injury.
Keywords : thrombocytopenia - severe traumatic brain injury - predictor - mortality
|
|---|