| 总结: | Iron deficiency is a major cause of anemia in children. Iron deficiency affect
child growth and decrease immune response. Gold standard for examination of iron
deficiency is invasive and not suitable for screening iron deficiency. Biochemical and
hematological parameters have several limitations. Biochemical and hematological
parameters have limitations. Soluble transferrin receptor (sTfR) is a clinical
marker of erythropoietic activity and sensitive to changes in serum iron status. It
is not influenced by inflammation and infection. STfR levels start to increase in
the second stage of iron deficiency. This study aims to determine the use of sTfR
for screening iron deficiency in children aged 6 months - 5 years in Yogyakarta.
This was a diagnostic study for screening with a cross-sectional design
using ferritin as a gold standard. Subjects were healthy children aged 6 months-5
years of Posyandu toddler in Yogyakarta and obtaining consent from the parents.
sTfR was examined with imunoturbidimetri method using cobas C 311. Ferritin
was checked using the Elecsys 1010 instrument with electrochemiluminescens
method. ROC curve analysis was performed using SPSS version 17. Sensitivity,
specificity, positive predictive value (NRP), negative predictive value (NRN),
accuracy, and positive likelihood ratio (LR +) and negative likelihood ratio (LR-)
were calculated with a 2x2 table.
There were 86 subjects who meet the inclusion and exclusion criteria.
Levels of sTfR the cut-off 4.44 mg / L had a sensitivity of 75%, specificity 71.8%,
21.4% NRP
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