| Summary: | Liver carcinoma is the most severe complication of cirrhosis with a high incidence. Liver carcinoma is often unrecognized until advanced stage. In previous studies in patients with liver cirrhosis and liver carcinoma found an elevation levels of von Willebrand factor (vWF). Increased plasma levels of vWF have also been reported in patients with various types of other cancers and positively correlated with advanced stage of the tumor and may have prognostic properties. Most of liver carcinoma developed from cirrhosis with different causes. Currently there are still limited data regarding difference plasma levels of vWF in cirrhosis and liver cancer. The aims of this study was to determine differences of vWF levels in patients with liver cirrhosis and carcinoma.
The study was conducted with a cross-sectional design. Sample were obtained by consecutive sampling methods. Subjects were patients with liver cirrhosis and liver carcinoma who visited as outpatient and inpatient in Internal Medicine Department of Dr. Sardjito Hospital, Yogyakarta at February to May 2014 who meet the inclusion and exclusion criteria. Differences vWF levels in liver cirrhosis and liver carcinoma were analyzed by Mann Whitney nonparametric test.
A total of 51 people met the criteria, consist of 34 (64.7%) patients with liver cirrhosis and 17 (33.3%) patients with liver carcinoma. Mean cirrhotic patients age was 53.79 ± 11.56 years, and 55.12 ± 10.99 in liver carcinoma. The number of male patients were 36 ( 70.6 % ), while 15 women ( 29.4 % ). Based on the cause of cirrhosis and liver carcinoma was hepatitis B virus infection 47.05 %, hepatitis C 17.65% and 35.30 % were obtained with non B and C hepatitis. Mean vWF levels in cirrhosis was 218.18±16.857% and 286.06±7.310% in liver carcinoma. The results of Mann Whitney statistical test shows significant differences between two populations (p < 0.001). In conclusions, Serum levels of von Willebrand factor was significantly higher in patients with liver carcinoma than with liver cirrhosis.
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