| Summary: | The complications in diabetes mellitus also required the consumption of other drugs besides antidiabetic drugs, which were considered to be able to overcome or prevent disease progression. The use of these drugs together with the antidiabetic drugs could cause drug interaction that may affect the effectiveness of therapy. So far it had not been known yet the connection of the drug interaction could affect the blood glucose level from type 2 diabetes mellitus patients. The research was intended to know the connection of drug interaction to blood glucose level. The research was an observational research using analytic research design retrospectively from the medical records of type 2 diabetes mellitus patients in Yogyakarta City Hospital and PKU Muhammadiyah Yogyakarta Hospital during the period 1st January 2012 – 31th December 2013. The data was presented descriptively in tables and percentages. The drug interaction data were analyzed in bivariate statistic to determine the connection of drug interaction and blood glucose level. The analysis of these data used the Chi-square test with 95% confidence level. There were 72 patients who met the inclusion and exclusion criteria (female 34 patients; 47.2% and male 38 patients; 52.8%). About 30 patients (41,7%) of the population were 61 – 70 years followed by the age of 51 – 60 years for 29 patients (40,3%). Mostly, the patient who has got type 2 diabetes mellitus with complications and another disease were about 64 patients (88,9%). Most of the therapy was the antidiabetic oral agents with insulin (43 patients; 59,7%). There were found 57 patients (79,2%) who has got the drug interactions and 15 patients (20,8%) who has not got the drug interactions. The statistical analysis with Chi-Square test showed that there was not any connections between drug interactions with blood glucose level (p = 0.265).
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