Korelasi Ekspresi Interleukin 6 Jaringan Kanker Kolorektal Dengan Kadar Carcinoembryonic Antigen Serum Penderita Adenokarsinoma Kolorektal
Background Interleukin-6 (IL-6) is a pleiotropic cytokine that is known to have a role in many physiological and pathophysiological functions. Some studies suggest that IL-6 is produced by tumor cells that function as a growth factor, it is also reported that colorectal cancers produce IL-6, resu...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2015
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| Summary: | Background Interleukin-6 (IL-6) is a pleiotropic cytokine that is known to have a
role in many physiological and pathophysiological functions. Some studies suggest
that IL-6 is produced by tumor cells that function as a growth factor, it is also
reported that colorectal cancers produce IL-6, resulting in increased IL-6 in the
colonic mucosa is a sign of excessive cell growth. Carcinoembryonic antigen (CEA)
is a glycosylated protein with a molecular mass of 180 kDa. Increased concentrations
of serum CEA found in patients with several types of cancer, especially colorectal
cancer. Increased levels of CEA in the blood associated with disease progression of
patients with colorectal cancer.
Objectives This study is being held to test the hypothesis that IL-6 expression in
colorectal cancer tissue has a positive correlation with serum CEA levels in colorectal
adenocarcinoma patients.
Methods We performed a cross sectional study. Sampling was done by consecutive
sampling. The subject of this study is the resection preparation of colorectal tissue
biopsies from all patients with adenocarcinoma colorectal with tissue samples are sent
to the department of Pathology Anatomy Dr. Sardjito between March 2010 and
March 2014 who meet the inclusion and exclusion criteria.
Statistical analysis number of samples and the study was 51 subjects. The results
showed a significant positive weak correlations between tissue overexpression of IL-
6 in colorectal cancer tissues and serum CEA levels increased of patients with
adenocarcinoma colorectal (r 0.330 |
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