Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)
Chemical investigation of the leaves of Garcinia griffithii(Guttiferae) has been carried out. The crude extract was obtained by using soxhlet extraction with n-hexane (n-Hexane) and methanol (MeOH) as the solvents. The MeOH crude exhact of the leaves of G. grifftthiiwere screened for antioxidant act...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English |
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2011
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| Online Access: | http://irep.iium.edu.my/13936/1/ICNP_SHAMSUL_SYAZWANI.pdf |
| _version_ | 1825645449839640576 |
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| author | Nik Sazali, Nik Shazwani Afifah Ahmad, Farediah Bakhtiar, M. Taher |
| author_facet | Nik Sazali, Nik Shazwani Afifah Ahmad, Farediah Bakhtiar, M. Taher |
| author_sort | Nik Sazali, Nik Shazwani Afifah |
| collection | IIUM |
| description | Chemical investigation of the leaves of Garcinia griffithii(Guttiferae) has been carried out. The crude extract was obtained by using soxhlet extraction with n-hexane (n-Hexane) and methanol (MeOH) as the solvents. The MeOH crude exhact of the leaves of G. grifftthiiwere screened for antioxidant activity by DPPH method. The result suggested that the extract was potentialantioxidant agent. The crude MeOH extract of G. griffithiiwas found to show free radicalscavenging activity with (lCso = 2995.11 pg/ml). The results of totalphenolic content assays indicated that methanolic crude extract ior G. griffithii
contained phenolic compounds. The total phenolic contents ol G. griffithii was expressed as pg gallic acid equivalent
(GAE/L)(406.31 s 2.39 pg/ml)and pg (i)-cathechin equivalent (CEiL)(BB1.Bg r 5.56 pg/ml). The n-hexane extract was
purified by using vacuum liquid chromatography (VLC) and column chromatography (CC) to get pure compounds. The
structures were elucidated by spectroscopic techniques such as lR and NMR (1H, 13C and DEPT) spectroscopy and GC-MS.
lsolation and characterization of the n-Hexane crude extract of G. oriffithiihave afforded soualene. friedooleanan-3-one and
stigmasta-5-en-3-ol. |
| first_indexed | 2024-03-05T22:47:54Z |
| format | Proceeding Paper |
| id | oai:generic.eprints.org:13936 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:47:54Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oai:generic.eprints.org:139362014-12-09T01:31:03Z http://irep.iium.edu.my/13936/ Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae) Nik Sazali, Nik Shazwani Afifah Ahmad, Farediah Bakhtiar, M. Taher RS Pharmacy and materia medica Chemical investigation of the leaves of Garcinia griffithii(Guttiferae) has been carried out. The crude extract was obtained by using soxhlet extraction with n-hexane (n-Hexane) and methanol (MeOH) as the solvents. The MeOH crude exhact of the leaves of G. grifftthiiwere screened for antioxidant activity by DPPH method. The result suggested that the extract was potentialantioxidant agent. The crude MeOH extract of G. griffithiiwas found to show free radicalscavenging activity with (lCso = 2995.11 pg/ml). The results of totalphenolic content assays indicated that methanolic crude extract ior G. griffithii contained phenolic compounds. The total phenolic contents ol G. griffithii was expressed as pg gallic acid equivalent (GAE/L)(406.31 s 2.39 pg/ml)and pg (i)-cathechin equivalent (CEiL)(BB1.Bg r 5.56 pg/ml). The n-hexane extract was purified by using vacuum liquid chromatography (VLC) and column chromatography (CC) to get pure compounds. The structures were elucidated by spectroscopic techniques such as lR and NMR (1H, 13C and DEPT) spectroscopy and GC-MS. lsolation and characterization of the n-Hexane crude extract of G. oriffithiihave afforded soualene. friedooleanan-3-one and stigmasta-5-en-3-ol. 2011 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/13936/1/ICNP_SHAMSUL_SYAZWANI.pdf Nik Sazali, Nik Shazwani Afifah and Ahmad, Farediah and Bakhtiar, M. Taher (2011) Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae). In: International Conference on Natural Products (ICNP 2011): Metabolomics - A New Frontier in Natural Products Science, 14-16 November 2011, Putrajaya, Malaysia. http://www.icnp2011.upm.edu.my/ |
| spellingShingle | RS Pharmacy and materia medica Nik Sazali, Nik Shazwani Afifah Ahmad, Farediah Bakhtiar, M. Taher Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae) |
| title | Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae) |
| title_full | Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae) |
| title_fullStr | Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae) |
| title_full_unstemmed | Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae) |
| title_short | Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae) |
| title_sort | chemical constituents and biological activities of the leaves of garcinia griffithii guttiferae |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/13936/1/ICNP_SHAMSUL_SYAZWANI.pdf |
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