Microencapsulation of gentamicin into PLGA-chitosan matrices
Poly (lactide-co-glycolide) (PLGA), are the most commonly used biodegradable synthetic polymers as it has extensive clinical applications and has shown to be effective in implantation drug delivery. In this project, chitosan mixed with PLGA were used to encapsulate gentamicin (model drug) to evaluat...
| Main Authors: | , , , |
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| Format: | Book Chapter |
| Language: | English |
| Published: |
IIUM Press
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/13966/1/CHAPTER_7%5B1%5D.pdf |
| _version_ | 1825645452769361920 |
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| author | Abdullah Hazim, Anas Harun Ismail, Ahmad Fahmi Awang, Mohamed Mohamed, Farahidah |
| author_facet | Abdullah Hazim, Anas Harun Ismail, Ahmad Fahmi Awang, Mohamed Mohamed, Farahidah |
| author_sort | Abdullah Hazim, Anas |
| collection | IIUM |
| description | Poly (lactide-co-glycolide) (PLGA), are the most commonly used biodegradable synthetic polymers as it has extensive clinical applications and has shown to be effective in implantation drug delivery. In this project, chitosan mixed with PLGA were used to encapsulate gentamicin (model drug) to evaluate feasibility of encapsulating highly water soluble drug. A modified single step solvent-evaporation method was employed to synthesize the microspheres. In this
study, different types of surfactants (PVA, Tween 20 and Span 80) were used to test the loading efficiency. surface morphology, and particle size of the microspheres. From the results obtained, fabrication of microspheres using the solvent-evaporation method has successfully produced a
locally administered drug delivery system for gentamicin. The application of different types of surfactants has yielded different microspheres characteristics with Tween 20 fabricated microspheres produced the smallest particle size, smooth surface morphology and the highest
encapsulation et1iciency
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| first_indexed | 2024-03-05T22:47:56Z |
| format | Book Chapter |
| id | oai:generic.eprints.org:13966 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:47:56Z |
| publishDate | 2011 |
| publisher | IIUM Press |
| record_format | dspace |
| spelling | oai:generic.eprints.org:139662012-08-27T06:41:51Z http://irep.iium.edu.my/13966/ Microencapsulation of gentamicin into PLGA-chitosan matrices Abdullah Hazim, Anas Harun Ismail, Ahmad Fahmi Awang, Mohamed Mohamed, Farahidah R Medicine (General) RS Pharmacy and materia medica Poly (lactide-co-glycolide) (PLGA), are the most commonly used biodegradable synthetic polymers as it has extensive clinical applications and has shown to be effective in implantation drug delivery. In this project, chitosan mixed with PLGA were used to encapsulate gentamicin (model drug) to evaluate feasibility of encapsulating highly water soluble drug. A modified single step solvent-evaporation method was employed to synthesize the microspheres. In this study, different types of surfactants (PVA, Tween 20 and Span 80) were used to test the loading efficiency. surface morphology, and particle size of the microspheres. From the results obtained, fabrication of microspheres using the solvent-evaporation method has successfully produced a locally administered drug delivery system for gentamicin. The application of different types of surfactants has yielded different microspheres characteristics with Tween 20 fabricated microspheres produced the smallest particle size, smooth surface morphology and the highest encapsulation et1iciency IIUM Press 2011 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/13966/1/CHAPTER_7%5B1%5D.pdf Abdullah Hazim, Anas and Harun Ismail, Ahmad Fahmi and Awang, Mohamed and Mohamed, Farahidah (2011) Microencapsulation of gentamicin into PLGA-chitosan matrices. In: Current Issues in Pharmacy. IIUM Press, Kuala Lumpur, pp. 112-128. ISBN 9789674180195 http://rms.research.iium.edu.my/bookstore/default.aspx |
| spellingShingle | R Medicine (General) RS Pharmacy and materia medica Abdullah Hazim, Anas Harun Ismail, Ahmad Fahmi Awang, Mohamed Mohamed, Farahidah Microencapsulation of gentamicin into PLGA-chitosan matrices |
| title | Microencapsulation of gentamicin into PLGA-chitosan matrices |
| title_full | Microencapsulation of gentamicin into PLGA-chitosan matrices |
| title_fullStr | Microencapsulation of gentamicin into PLGA-chitosan matrices |
| title_full_unstemmed | Microencapsulation of gentamicin into PLGA-chitosan matrices |
| title_short | Microencapsulation of gentamicin into PLGA-chitosan matrices |
| title_sort | microencapsulation of gentamicin into plga chitosan matrices |
| topic | R Medicine (General) RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/13966/1/CHAPTER_7%5B1%5D.pdf |
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