Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides
S. pyogenes secrete a large array of molecules that might contribute to resistance against the human’s antimicrobial peptides (AMPs). Some of these are anchored in the cell-wall by enzymes called sortases and others are released from the cell after secretion. Two released proteins that have previous...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2010
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| Online Access: | http://irep.iium.edu.my/15937/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf |
| _version_ | 1796876274117902336 |
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| author | Shahdan, Intan Azura Hall, Judith Kehoe, Mike |
| author_facet | Shahdan, Intan Azura Hall, Judith Kehoe, Mike |
| author_sort | Shahdan, Intan Azura |
| collection | IIUM |
| description | S. pyogenes secrete a large array of molecules that might contribute to resistance against the human’s antimicrobial peptides (AMPs). Some of these are anchored in the cell-wall by enzymes called sortases and others are released from the cell after secretion. Two released proteins that have previously been reported to inhibit bactericidal effect of the AMPs are streptococcal inhibitor of complement (SIC) and cysteine protease, SpeB. In this study, several S. pyogenes strain SF370 deletion mutants were compared to the parent wild-type strain for resistance to the AMPs LL-37 and LEAP-2. We found that released proteins SIC and SpeB contribute to streptococcal resistance against LL-37; and cell wallanchored proteins by sortases SrtA and SrtC are also important in streptococcal resistance against LL-37 but not with LEAP-2. Our study conclude that LL-37 kills S. pyogenes strain SF370 better than LEAP-2 peptide. |
| first_indexed | 2024-03-05T22:50:07Z |
| format | Proceeding Paper |
| id | oai:generic.eprints.org:15937 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:50:07Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oai:generic.eprints.org:159372012-01-30T03:09:00Z http://irep.iium.edu.my/15937/ Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides Shahdan, Intan Azura Hall, Judith Kehoe, Mike Q Science (General) S. pyogenes secrete a large array of molecules that might contribute to resistance against the human’s antimicrobial peptides (AMPs). Some of these are anchored in the cell-wall by enzymes called sortases and others are released from the cell after secretion. Two released proteins that have previously been reported to inhibit bactericidal effect of the AMPs are streptococcal inhibitor of complement (SIC) and cysteine protease, SpeB. In this study, several S. pyogenes strain SF370 deletion mutants were compared to the parent wild-type strain for resistance to the AMPs LL-37 and LEAP-2. We found that released proteins SIC and SpeB contribute to streptococcal resistance against LL-37; and cell wallanchored proteins by sortases SrtA and SrtC are also important in streptococcal resistance against LL-37 but not with LEAP-2. Our study conclude that LL-37 kills S. pyogenes strain SF370 better than LEAP-2 peptide. 2010 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/15937/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf Shahdan, Intan Azura and Hall, Judith and Kehoe, Mike (2010) Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides. In: IIUM Research, Innovation & Invention Exhibition (IRIIE 2010), 26 - 27 January 2010, Kuala Lumpur. http://www.iium.edu.my/irie/10/info/Programme_Book%20Part_2.pdf |
| spellingShingle | Q Science (General) Shahdan, Intan Azura Hall, Judith Kehoe, Mike Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides |
| title | Streptococcus pyogenes proteins involved in resistance to
antimicrobial peptides |
| title_full | Streptococcus pyogenes proteins involved in resistance to
antimicrobial peptides |
| title_fullStr | Streptococcus pyogenes proteins involved in resistance to
antimicrobial peptides |
| title_full_unstemmed | Streptococcus pyogenes proteins involved in resistance to
antimicrobial peptides |
| title_short | Streptococcus pyogenes proteins involved in resistance to
antimicrobial peptides |
| title_sort | streptococcus pyogenes proteins involved in resistance to antimicrobial peptides |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/15937/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf |
| work_keys_str_mv | AT shahdanintanazura streptococcuspyogenesproteinsinvolvedinresistancetoantimicrobialpeptides AT halljudith streptococcuspyogenesproteinsinvolvedinresistancetoantimicrobialpeptides AT kehoemike streptococcuspyogenesproteinsinvolvedinresistancetoantimicrobialpeptides |