Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants
Malaysia has a rich diversity of medicinal plants and some of them are believed to have the property to inhibit xanthine oxidase activity, which can be introduced as a new natural source of gout medication and a substitute for synthetic xanthine oxidase inhibitors (XOI). In this study, forty two sam...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English |
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2010
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| Online Access: | http://irep.iium.edu.my/16828/1/UMTAS_2010_XOI.pdf |
| _version_ | 1825645659932327936 |
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| author | Jamal, Parveen Azmi, Saiful Mohammad Nizam Amid, Azura |
| author_facet | Jamal, Parveen Azmi, Saiful Mohammad Nizam Amid, Azura |
| author_sort | Jamal, Parveen |
| collection | IIUM |
| description | Malaysia has a rich diversity of medicinal plants and some of them are believed to have the property to inhibit xanthine oxidase activity, which can be introduced as a new natural source of gout medication and a substitute for synthetic xanthine oxidase inhibitors (XOI). In this study, forty two samples from seventeen plant species were examined for xanthine oxidase inhibitory activity. Selection of plants was based on their frequent usages by local folks for their medicinal benefits and their activity in three different extraction solvents. The degree of XO inhibition was determined by measuring the absorbance spectrophotometrically at 295 nm associated with uric acid formation. Ninety-nine percent of the crude extracts were found to have XO inhibitory activity at 100 μg/ml, and 59% showed greater than 50% inhibition. The ripe fruit peels of Garcinia mangostana L. has the potential to be exploited as an alternative to allopurinol as the crude extracts of this plant material from all three solvents, namely, 70% methanol, ethanol and distilled water, exhibited the highest XOI activity with 88.74%, 84.69% and 80.18% inhibition, respectively. The ripe fruit peels of Cucumis sativus and the leaves of Morinda citrifolia can also be considered as potential alternatives to allopurinol as they have demonstrated the second and third highest XOI activity especially with 70% methanol as the extraction solvent. |
| first_indexed | 2024-03-05T22:51:02Z |
| format | Proceeding Paper |
| id | oai:generic.eprints.org:16828 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:51:02Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oai:generic.eprints.org:168282012-07-24T23:41:29Z http://irep.iium.edu.my/16828/ Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants Jamal, Parveen Azmi, Saiful Mohammad Nizam Amid, Azura TA164 Bioengineering TP248.13 Biotechnology Malaysia has a rich diversity of medicinal plants and some of them are believed to have the property to inhibit xanthine oxidase activity, which can be introduced as a new natural source of gout medication and a substitute for synthetic xanthine oxidase inhibitors (XOI). In this study, forty two samples from seventeen plant species were examined for xanthine oxidase inhibitory activity. Selection of plants was based on their frequent usages by local folks for their medicinal benefits and their activity in three different extraction solvents. The degree of XO inhibition was determined by measuring the absorbance spectrophotometrically at 295 nm associated with uric acid formation. Ninety-nine percent of the crude extracts were found to have XO inhibitory activity at 100 μg/ml, and 59% showed greater than 50% inhibition. The ripe fruit peels of Garcinia mangostana L. has the potential to be exploited as an alternative to allopurinol as the crude extracts of this plant material from all three solvents, namely, 70% methanol, ethanol and distilled water, exhibited the highest XOI activity with 88.74%, 84.69% and 80.18% inhibition, respectively. The ripe fruit peels of Cucumis sativus and the leaves of Morinda citrifolia can also be considered as potential alternatives to allopurinol as they have demonstrated the second and third highest XOI activity especially with 70% methanol as the extraction solvent. 2010-05 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/16828/1/UMTAS_2010_XOI.pdf Jamal, Parveen and Azmi, Saiful Mohammad Nizam and Amid, Azura (2010) Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants. In: UMT 9th International Annual Symposium on Sustainability Science and Management (UMTAS 2010), 8 - 11 May 2010, Terengganu, Malaysia. http://www.umt.edu.my/penerbitumt |
| spellingShingle | TA164 Bioengineering TP248.13 Biotechnology Jamal, Parveen Azmi, Saiful Mohammad Nizam Amid, Azura Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants |
| title | Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants |
| title_full | Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants |
| title_fullStr | Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants |
| title_full_unstemmed | Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants |
| title_short | Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants |
| title_sort | screening of xanthine oxidase inhibitor from potential malaysian medicinal plants |
| topic | TA164 Bioengineering TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/16828/1/UMTAS_2010_XOI.pdf |
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