Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ...
It has been conducted the synthesis of 3-(2-hydroxyethyl)-2-methyl-1,10-phenanthroline-4-ol was carried out from 8-aminoquinoline which are expected to posses antimalarial activity. The experiment perfomed consisted of two steps i.e (1) reaction of 8-aminoquinoline with 2-acetyl-butyrolactone and (2...
| Main Author: | |
|---|---|
| Format: | Article |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2004
|
| Subjects: |
| _version_ | 1826031118827126784 |
|---|---|
| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | It has been conducted the synthesis of 3-(2-hydroxyethyl)-2-methyl-1,10-phenanthroline-4-ol was carried out from 8-aminoquinoline which are expected to posses antimalarial activity. The experiment perfomed consisted of two steps i.e (1) reaction of 8-aminoquinoline with 2-acetyl-butyrolactone and (2) cyclization of the resulted 341-(quinolin-8-ylamino)-ethylidene1-4,5-dihydro-furan-2-one. The reaction of 8- aminoquinoline with 2-acetyl-butyrolactone was performed in toluene at reflux for 6 hours in the presence of p-toluensulfonic acid as catalyst. This reaction gave 3-11-(quinolin-8-ilamino)-etilidetd-4,5-dihidro-furan-2-on in 60.6% yield. The cyclization of 3(1-(quinoline-8-ylamino)-ethyliden]-4,5-dihydro-furan-2-one was conducted in cloroform at reflux for 4 hours in the presence of H2SO4 as catalyst and also tween 80 as transfer phase catalyst to give 3-(2-hydroxy-ethyl)-2-methyl-1,10-phenanthroline-4-ol in 76.2% yield. Identification of the products were carried out by means of infra red (IR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy, and mass spectroscopy (MS).
Keywords: antimalarial, 8-aminoquinoline, cyclization, 1,10-phenantroline |
| first_indexed | 2024-03-13T18:33:23Z |
| format | Article |
| id | oai:generic.eprints.org:17602 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T18:33:23Z |
| publishDate | 2004 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:176022014-06-18T00:29:23Z https://repository.ugm.ac.id/17602/ Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ... Perpustakaan UGM, i-lib Jurnal i-lib UGM It has been conducted the synthesis of 3-(2-hydroxyethyl)-2-methyl-1,10-phenanthroline-4-ol was carried out from 8-aminoquinoline which are expected to posses antimalarial activity. The experiment perfomed consisted of two steps i.e (1) reaction of 8-aminoquinoline with 2-acetyl-butyrolactone and (2) cyclization of the resulted 341-(quinolin-8-ylamino)-ethylidene1-4,5-dihydro-furan-2-one. The reaction of 8- aminoquinoline with 2-acetyl-butyrolactone was performed in toluene at reflux for 6 hours in the presence of p-toluensulfonic acid as catalyst. This reaction gave 3-11-(quinolin-8-ilamino)-etilidetd-4,5-dihidro-furan-2-on in 60.6% yield. The cyclization of 3(1-(quinoline-8-ylamino)-ethyliden]-4,5-dihydro-furan-2-one was conducted in cloroform at reflux for 4 hours in the presence of H2SO4 as catalyst and also tween 80 as transfer phase catalyst to give 3-(2-hydroxy-ethyl)-2-methyl-1,10-phenanthroline-4-ol in 76.2% yield. Identification of the products were carried out by means of infra red (IR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy, and mass spectroscopy (MS). Keywords: antimalarial, 8-aminoquinoline, cyclization, 1,10-phenantroline [Yogyakarta] : Universitas Gadjah Mada 2004 Article NonPeerReviewed Perpustakaan UGM, i-lib (2004) Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ... Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=361 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ... |
| title | Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ... |
| title_full | Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ... |
| title_fullStr | Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ... |
| title_full_unstemmed | Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ... |
| title_short | Synthesis of Antimalarial 3-(2-Hydroxyethyl)-2-Methyl-1, 10-Phenanthroline-4-OL from 8-Aminoqueinoline = Sintesis Senyawa Antimalaria 3- ... |
| title_sort | synthesis of antimalarial 3 2 hydroxyethyl 2 methyl 1 10 phenanthroline 4 ol from 8 aminoqueinoline sintesis senyawa antimalaria 3 |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib synthesisofantimalarial32hydroxyethyl2methyl110phenanthroline4olfrom8aminoqueinolinesintesissenyawaantimalaria3 |