Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi
ABSTRACT Analytical method for the determination of paracetamol and ibuprofene mixtures has been developed by High Performance Liquid Chromatography using C-18 column and acetinitrile � phosphate buffer pH = 4.5 (75:25) containing 0.075 % sodium hexanesulfunate as a mobile phase. The detector was...
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| Format: | Article |
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[Yogyakarta] : Universitas Gadjah Mada
2003
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| _version_ | 1797017706653810688 |
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| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | ABSTRACT
Analytical method for the determination of paracetamol and ibuprofene mixtures has been developed by High Performance Liquid Chromatography using C-18 column and acetinitrile � phosphate buffer pH = 4.5 (75:25) containing 0.075 % sodium hexanesulfunate as a mobile phase. The detector was set at 215 nm. Using such conditions, retention time for paracetamol and ibuprofen was 4.89 and 7.11 min, respectively. The recovery for paracetamol and ibuprofen was found to be 101.07± 0.73 % and 102.02 ± 1.58 %, respectively. The detector limits of the method was 1.30 and 1.60 pg/ml with the relative standard deviation (RSD) 0.74 and 1.52 % for paracetamol and ibuprofen, respectively.
Keywords: paracetamol, ibuprofen, multi-component, validation, HPLC |
| first_indexed | 2024-03-13T18:34:35Z |
| format | Article |
| id | oai:generic.eprints.org:17975 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T18:34:35Z |
| publishDate | 2003 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:179752014-06-18T00:30:57Z https://repository.ugm.ac.id/17975/ Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi Perpustakaan UGM, i-lib Jurnal i-lib UGM ABSTRACT Analytical method for the determination of paracetamol and ibuprofene mixtures has been developed by High Performance Liquid Chromatography using C-18 column and acetinitrile � phosphate buffer pH = 4.5 (75:25) containing 0.075 % sodium hexanesulfunate as a mobile phase. The detector was set at 215 nm. Using such conditions, retention time for paracetamol and ibuprofen was 4.89 and 7.11 min, respectively. The recovery for paracetamol and ibuprofen was found to be 101.07± 0.73 % and 102.02 ± 1.58 %, respectively. The detector limits of the method was 1.30 and 1.60 pg/ml with the relative standard deviation (RSD) 0.74 and 1.52 % for paracetamol and ibuprofen, respectively. Keywords: paracetamol, ibuprofen, multi-component, validation, HPLC [Yogyakarta] : Universitas Gadjah Mada 2003 Article NonPeerReviewed Perpustakaan UGM, i-lib (2003) Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=750 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi |
| title | Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi |
| title_full | Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi |
| title_fullStr | Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi |
| title_full_unstemmed | Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi |
| title_short | Simultaneous Determination Of Paracetamol And Ibuprofene Mixtures By High Performance Liquid Chromatography = Penetapan secara Simultan Campuran Parasetamol dan Ibuprofen dengan Kromatografi Cair Kinerja Tinggi |
| title_sort | simultaneous determination of paracetamol and ibuprofene mixtures by high performance liquid chromatography penetapan secara simultan campuran parasetamol dan ibuprofen dengan kromatografi cair kinerja tinggi |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib simultaneousdeterminationofparacetamolandibuprofenemixturesbyhighperformanceliquidchromatographypenetapansecarasimultancampuranparasetamoldanibuprofendengankromatograficairkinerjatinggi |