Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis.
A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor bind...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2009
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/18073/4/irwandi_10826070903297459.fp.png_v03.pdf |
| _version_ | 1825645789687316480 |
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| author | Sarker, Md. Zaidul Islam Khatib, Alfi Yuliana, Nancy Dewi Selamat, Jinap Jaswir, Irwandi Wilson, Erica G. Chung, Shin_Kyo Verpoorte, Robert |
| author_facet | Sarker, Md. Zaidul Islam Khatib, Alfi Yuliana, Nancy Dewi Selamat, Jinap Jaswir, Irwandi Wilson, Erica G. Chung, Shin_Kyo Verpoorte, Robert |
| author_sort | Sarker, Md. Zaidul Islam |
| collection | IIUM |
| description | A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxyflavonoids, fatty acids or terpenoids were estimated to be related to this activity. The results of this study support the traditional use in Indonesia of O. stamineus as a functional drink to treat kidney stones. |
| first_indexed | 2024-03-05T22:52:59Z |
| format | Article |
| id | oai:generic.eprints.org:18073 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:52:59Z |
| publishDate | 2009 |
| publisher | Taylor & Francis Group |
| record_format | dspace |
| spelling | oai:generic.eprints.org:180732021-07-30T03:40:39Z http://irep.iium.edu.my/18073/ Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. Sarker, Md. Zaidul Islam Khatib, Alfi Yuliana, Nancy Dewi Selamat, Jinap Jaswir, Irwandi Wilson, Erica G. Chung, Shin_Kyo Verpoorte, Robert TP368 Food processing and manufacture A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxyflavonoids, fatty acids or terpenoids were estimated to be related to this activity. The results of this study support the traditional use in Indonesia of O. stamineus as a functional drink to treat kidney stones. Taylor & Francis Group 2009 Article PeerReviewed application/pdf en http://irep.iium.edu.my/18073/4/irwandi_10826070903297459.fp.png_v03.pdf Sarker, Md. Zaidul Islam and Khatib, Alfi and Yuliana, Nancy Dewi and Selamat, Jinap and Jaswir, Irwandi and Wilson, Erica G. and Chung, Shin_Kyo and Verpoorte, Robert (2009) Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. Journal of Liquid Chromatography & Related Technologies, 32 (19). pp. 2906-2916. ISSN 1082-6076 (p)1520-572X (o) |
| spellingShingle | TP368 Food processing and manufacture Sarker, Md. Zaidul Islam Khatib, Alfi Yuliana, Nancy Dewi Selamat, Jinap Jaswir, Irwandi Wilson, Erica G. Chung, Shin_Kyo Verpoorte, Robert Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. |
| title | Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. |
| title_full | Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. |
| title_fullStr | Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. |
| title_full_unstemmed | Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. |
| title_short | Identification of possible compounds posessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. |
| title_sort | identification of possible compounds posessing adenosine a1 receptor binding activity in the leaves of orthosiphon stamineus using tlc and multivariate data analysis |
| topic | TP368 Food processing and manufacture |
| url | http://irep.iium.edu.my/18073/4/irwandi_10826070903297459.fp.png_v03.pdf |
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