Herpes simplex virus infection. The roles of T4ymphocytes in host responses
ABSTRACT T-lymphocytes are the most important component of the immune response to control recurrent infections. T-Iumphocytes of CD4+ and CD8 + recognize a variety of viral proteins and produce lymphokines with antiviral and immunomodulatory effects. Both CD4+ and CIDER- bearing T-cells can kill HSV...
| Main Author: | |
|---|---|
| Format: | Article |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
1996
|
| Subjects: |
| Summary: | ABSTRACT
T-lymphocytes are the most important component of the immune response to control recurrent infections. T-Iumphocytes of CD4+ and CD8 + recognize a variety of viral proteins and produce lymphokines with antiviral and immunomodulatory effects. Both CD4+ and CIDER- bearing T-cells can kill HSV infected host cells. The relation between specific T-cells responses and severity of HSV disease have not been consistently detected. Interaction between T-cells responses and HSV and host cells result in a dynamic state of latency. HSV has evolved special mechanisms for evasion of host immunity. Reactivation can result in recurrences with the implication of transmission and/or disease. Molecular definition of T-cell responses for HSV may lead to immunological intervention to prevent HSV disease. Impaired T-cell immunity should be considered as a risk factor for severe infections.
Key words: herpes simplex - T-cell role - latency - immunocompromised - vaccine
Limfosit-T merupakan komponen utama respon imun dalam mengendalikan infeksi rekuren. Sel-T CD4+ dan CD8 + dapat mengenal protein-protein virus dan memproduksi limfokin yang mempunyai sifat antivirus dan imunomodulator. Sel-T CM+ dan CD8 + mampu membunuh sel pejamu yang terinfeksi. Hubungan antara respon sel-T yang spesifik dan derajat penyakit belum dapat dipastikan. Interaksi antara respon sel-T dengan virus dan sel pejamu menyebabkan keadaan laten sebagai keadaan yang dinamis. Virus herpes simplek (HSV) mempunyai kemampuan khusus untuk menghindar dari imunitas pejamu. Reaktivasi HSV laten menyebabkan kekambuhan dengan implikasi terjadinya penularan dan atau penyakit. Dasar molekular dari respon sel-T terhadap HSV dapat digunakan dalam tindakan intervensi imunologik untuk pencegahan infeksi HSV. Kelumpuhan imunitas sel-T merupakan faktor risiko terjadinya infeksi yang hebat. |
|---|