Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.
Crystallization is an important unit operation used in a variety of industries. Its importance in the pharmaceutical industries is due to a large number of active pharmaceutical ingredients that are utilised in solid form. It is estimated that more than 80% ofpharmaceutical products involve at least...
| Main Authors: | , |
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| Format: | Book Chapter |
| Language: | English |
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IIUM Press
2011
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| Online Access: | http://irep.iium.edu.my/18493/1/CHAPTER_8%5B1%5D.pdf |
| _version_ | 1825645839538716672 |
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| author | Abu Bakar, Mohd Rushdi Nagy, Zoltan K. |
| author_facet | Abu Bakar, Mohd Rushdi Nagy, Zoltan K. |
| author_sort | Abu Bakar, Mohd Rushdi |
| collection | IIUM |
| description | Crystallization is an important unit operation used in a variety of industries. Its importance in the pharmaceutical industries is due to a large number of active pharmaceutical ingredients that are utilised in solid form. It is estimated that more than 80% ofpharmaceutical products involve at least one crystallization step in their manufacturing process (Reutzel-Edens, 2006). The
pharmaceutical crystallisation operation is often critical because it determines the product properties, such as the crystal size distribution, morphology and polymorphic form. These properties in tum influence the efficiency of the subsequent downstream operations, particularly
filtration and drying. The properties also affect the therapeutic performance ofthe product, such as dissolution rate and bioavailability. A proper control of crystallization processes offers possibilities for improved process efficiency and better product quality |
| first_indexed | 2024-03-05T22:53:42Z |
| format | Book Chapter |
| id | oai:generic.eprints.org:18493 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-13T18:27:47Z |
| publishDate | 2011 |
| publisher | IIUM Press |
| record_format | dspace |
| spelling | oai:generic.eprints.org:184932012-08-27T07:24:18Z http://irep.iium.edu.my/18493/ Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. Abu Bakar, Mohd Rushdi Nagy, Zoltan K. RS Pharmacy and materia medica Crystallization is an important unit operation used in a variety of industries. Its importance in the pharmaceutical industries is due to a large number of active pharmaceutical ingredients that are utilised in solid form. It is estimated that more than 80% ofpharmaceutical products involve at least one crystallization step in their manufacturing process (Reutzel-Edens, 2006). The pharmaceutical crystallisation operation is often critical because it determines the product properties, such as the crystal size distribution, morphology and polymorphic form. These properties in tum influence the efficiency of the subsequent downstream operations, particularly filtration and drying. The properties also affect the therapeutic performance ofthe product, such as dissolution rate and bioavailability. A proper control of crystallization processes offers possibilities for improved process efficiency and better product quality IIUM Press 2011 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/18493/1/CHAPTER_8%5B1%5D.pdf Abu Bakar, Mohd Rushdi and Nagy, Zoltan K. (2011) Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. In: Current Issues in Pharmacy. IIUM Press, Kuala Lumpur , pp. 129-155. ISBN 9789674180195 http://rms.research.iium.edu.my/bookstore/default.aspx |
| spellingShingle | RS Pharmacy and materia medica Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. |
| title | Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. |
| title_full | Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. |
| title_fullStr | Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. |
| title_full_unstemmed | Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. |
| title_short | Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. |
| title_sort | process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/18493/1/CHAPTER_8%5B1%5D.pdf |
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