FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI

Genetic screening for D-thalassemia trait was carried out in Ambon population of the Moluccas, a population genetically related with other eastern Indonesian populations with strong Melanesian influence where HbE gene frequency is very low. Blood specimens were collected from 92 adult healthy unrela...

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Main Author: Perpustakaan UGM, i-lib
Format: Article
Published: [Yogyakarta] : Universitas Gadjah Mada 1994
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author Perpustakaan UGM, i-lib
author_facet Perpustakaan UGM, i-lib
author_sort Perpustakaan UGM, i-lib
collection UGM
description Genetic screening for D-thalassemia trait was carried out in Ambon population of the Moluccas, a population genetically related with other eastern Indonesian populations with strong Melanesian influence where HbE gene frequency is very low. Blood specimens were collected from 92 adult healthy unrelated individuals consists of 32 males and 60 females mostly student nurses participated in the study. Three blood indices, hemoglobin concentration, packed cell volume and MCHC were normal. However, increase of HbA2 concentration was observed in six individuals (6.5%). Unlike the previous study, not even single individual with abnormally structural hemoglobin was found in this study. The occurrence of carrier of this genetic traits comparable with previous studies in Java, again confirms the interaction of 13-thalassemia and HbE distribution in malaria endemic region. Further measures include premarital genetic counseling should be considered to avoid public health problem that may be created in the future. Key words : genetic screening, B-thalassemia trait, malaria endemic, premarital genetic counseling
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spelling oai:generic.eprints.org:185432014-06-18T00:39:36Z https://repository.ugm.ac.id/18543/ FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI Perpustakaan UGM, i-lib Jurnal i-lib UGM Genetic screening for D-thalassemia trait was carried out in Ambon population of the Moluccas, a population genetically related with other eastern Indonesian populations with strong Melanesian influence where HbE gene frequency is very low. Blood specimens were collected from 92 adult healthy unrelated individuals consists of 32 males and 60 females mostly student nurses participated in the study. Three blood indices, hemoglobin concentration, packed cell volume and MCHC were normal. However, increase of HbA2 concentration was observed in six individuals (6.5%). Unlike the previous study, not even single individual with abnormally structural hemoglobin was found in this study. The occurrence of carrier of this genetic traits comparable with previous studies in Java, again confirms the interaction of 13-thalassemia and HbE distribution in malaria endemic region. Further measures include premarital genetic counseling should be considered to avoid public health problem that may be created in the future. Key words : genetic screening, B-thalassemia trait, malaria endemic, premarital genetic counseling [Yogyakarta] : Universitas Gadjah Mada 1994 Article NonPeerReviewed Perpustakaan UGM, i-lib (1994) FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=1334
spellingShingle Jurnal i-lib UGM
Perpustakaan UGM, i-lib
FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI
title FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI
title_full FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI
title_fullStr FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI
title_full_unstemmed FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI
title_short FREKUENSI TRAIT THALASSEMIA-b DI AMBON, MALUKI
title_sort frekuensi trait thalassemia b di ambon maluki
topic Jurnal i-lib UGM
work_keys_str_mv AT perpustakaanugmilib frekuensitraitthalassemiabdiambonmaluki