| Summary: | The study was aimed to compare the effects of combination of timolol maleat 0.5% and pilocarpine 2% to acetazolamide 250mg in the treatment of a primary glaucoma. We studied 13 patients with open angle glaucomas and 11 patients with closed angle glaucomas. This study was carried out in a randomized double blind clinical trial. The patients were divided into two groups, A and B. Group A consisted of patients treated with 250 mg acetazolamide t.i.d. and the group B was treated with combination of 0.5% timolol maleat b.i.d. and 2 % pilocarpine q.i.d. This one-day treatment was stopped and seven days later the treatment was interchanged between the two groups. The intraocular pressures were measured just before and two hours after the treatment. The mean decrease of 10P in group A was 17.042 ± 14.212mmHg and that of group B was 17.873 ± 9.005 mmHg. There was statistically no significant difference (p=0.804) between two groups. The mean decrease of 10P in primary open angle glaucoma in group A was 8.685 ± 6.389 mmHg and that of group B was 15.054 ± 5.994 mmHg. Statistically there was significant difference (p = 0.014). The mean decrease of 10P In primary closed angle glaucoma in group A was 26.918 ± 14.748mmHg and that of group B was 21.205 ± 10.993 mmHg. Statistically there was no significant difference (p = 0.3162). In conclusion, there was no significant difference between the use of acetazolamide 250mg q.i.d. the combination of timolol maleat 0.5% b.i.d. and pilocarpine 2% q.i.d. in reducing the 10P of primary glaucoma.
Key words: primary glaucoma - lop decrease - acetazolamide - timolol maleat - pilocarpine.
Tujuan penelitian iffi adalah mempelajari pengaruh penurunan tekanan intraokular setelah pemberian acetazolamide dibandingkan dengan kombinasi timolol maleat dan pilokarpin pada glaukoma primer. Telah dilakukan penelitian uji klinis secara acak buta ganda pada penderita glaukoma primer. Penderita glaukoma sudut terbuka primer berjumlah 13 orang sedangkan glaukoma sudut tetutup primer berjumlah 11 orang. Penelitian ini dibagi menjadi dua kelompok perlakuan. Kelompok perlakuan A mendapat acetazolamide 3 x 250mg dan kelompok B mendapat kombinasi timolol maleat 0,5% 2 x dan pilokarpin 2% 4 x dalam 24 jam. Pengobatan dihentikan selama 7 hari kemudian dilakukan crossing over di mana kelompok perlakuan A mendapat perlakuan B dan sebaliknya. Sebelum dan sesudah perlakuan dilakukan pengukuran tekanan intraokular pada masing-masing kelompok perlakuan. Dad penelitian didapatkan rerata penurunan tekanan intraokular kelompok perlakuan A sebesar 17,042 ± 14,212 mmHg dan kelompok perlakuan B sebesar 17,873 ± 9.005 mmHg. Dengan uji
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