Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients
Objective: Despite the availability of modern anti-emetics, chemotherapy-induced nausea and vomiting (CINV) symptoms remain distressing to a high number of cancer patients. This study intended to (1) describe the incidence of CINV and anti-emetic usage; (2) assess the health-related quality of life...
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| Format: | Article |
| Language: | English English |
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ASEAN Federation of Psychiatry
2012
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| Online Access: | http://irep.iium.edu.my/18737/6/Health_Related_Quality_of_Life_Profile.pdf http://irep.iium.edu.my/18737/8/Suhana_ASEAN_87-292-1-RV.pdf |
| _version_ | 1825645865219391488 |
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| author | Pei, Lin Lua Zakaria, Noor Salihah Mamat, Nik Mazlan |
| author_facet | Pei, Lin Lua Zakaria, Noor Salihah Mamat, Nik Mazlan |
| author_sort | Pei, Lin Lua |
| collection | IIUM |
| description | Objective: Despite the availability of modern anti-emetics, chemotherapy-induced nausea and vomiting (CINV) symptoms remain distressing to a high number of cancer patients. This study intended to (1) describe the incidence of CINV and anti-emetic usage; (2) assess the health-related quality of life (HRQoL) and correlate its components with Global Health Status; (3) evaluate HRQoL status in relation to CINV among breast cancer patients receiving chemotherapy. Methods: A cross sectional study was conducted in two government hospitals located in the East Coast of Peninsular Malaysia (Terengganu, Kelantan). The Morrow Assessment of Nausea and Emesis Follow-up (MANE-FU) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were administered. Descriptive statistics and non-parametric tests were employed (SPSS 16). Results: Respondents included 41 female patients (age = 49 ± 9.6 years; Malay = 92.7%; no family history of breast cancer = 68.3% and on moderately emetogenic chemotherapy = 97.6%). Majority of patients experienced nausea during or after chemotherapy (90.2%) and rated it as ‘severe’. Most patients had taken anti-emetic (87.8%) and considered it ‘somewhat useful’. The median score for Global Health Status was 50 (IqR= 16.7). Emotional Functioning, Fatigue and Pain correlated fairly with HRQoL (rs= +0.435; -0.417; -0.387 respectively). Patients with ‘a lot’ and ‘moderate’ nausea displayed significantly more fatigue compared to those with little nausea (p=0.029). Those who experienced vomiting reported worse HRQoL profile compared to those who did not (p=0.011). Conclusion: These findings generally ascertained that CINV remains poorly controlled and significantly interferes with HRQoL, providing rooms for improvements in therapeutic intervention. |
| first_indexed | 2024-03-05T22:54:05Z |
| format | Article |
| id | oai:generic.eprints.org:18737 |
| institution | International Islamic University Malaysia |
| language | English English |
| last_indexed | 2024-03-13T18:28:36Z |
| publishDate | 2012 |
| publisher | ASEAN Federation of Psychiatry |
| record_format | dspace |
| spelling | oai:generic.eprints.org:187372013-12-06T08:18:53Z http://irep.iium.edu.my/18737/ Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients Pei, Lin Lua Zakaria, Noor Salihah Mamat, Nik Mazlan RS Pharmacy and materia medica Objective: Despite the availability of modern anti-emetics, chemotherapy-induced nausea and vomiting (CINV) symptoms remain distressing to a high number of cancer patients. This study intended to (1) describe the incidence of CINV and anti-emetic usage; (2) assess the health-related quality of life (HRQoL) and correlate its components with Global Health Status; (3) evaluate HRQoL status in relation to CINV among breast cancer patients receiving chemotherapy. Methods: A cross sectional study was conducted in two government hospitals located in the East Coast of Peninsular Malaysia (Terengganu, Kelantan). The Morrow Assessment of Nausea and Emesis Follow-up (MANE-FU) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were administered. Descriptive statistics and non-parametric tests were employed (SPSS 16). Results: Respondents included 41 female patients (age = 49 ± 9.6 years; Malay = 92.7%; no family history of breast cancer = 68.3% and on moderately emetogenic chemotherapy = 97.6%). Majority of patients experienced nausea during or after chemotherapy (90.2%) and rated it as ‘severe’. Most patients had taken anti-emetic (87.8%) and considered it ‘somewhat useful’. The median score for Global Health Status was 50 (IqR= 16.7). Emotional Functioning, Fatigue and Pain correlated fairly with HRQoL (rs= +0.435; -0.417; -0.387 respectively). Patients with ‘a lot’ and ‘moderate’ nausea displayed significantly more fatigue compared to those with little nausea (p=0.029). Those who experienced vomiting reported worse HRQoL profile compared to those who did not (p=0.011). Conclusion: These findings generally ascertained that CINV remains poorly controlled and significantly interferes with HRQoL, providing rooms for improvements in therapeutic intervention. ASEAN Federation of Psychiatry 2012-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/18737/6/Health_Related_Quality_of_Life_Profile.pdf application/pdf en http://irep.iium.edu.my/18737/8/Suhana_ASEAN_87-292-1-RV.pdf Pei, Lin Lua and Zakaria, Noor Salihah and Mamat, Nik Mazlan (2012) Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients. ASEAN Journal of Psychiatry, 13 (1). pp. 3-12. ISSN 2231-7805 (P) 2231-7791 (O) http://www.aseanjournalofpsychiatry.org/index.php/aseanjournalofpsychiatry/article/view/70 |
| spellingShingle | RS Pharmacy and materia medica Pei, Lin Lua Zakaria, Noor Salihah Mamat, Nik Mazlan Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients |
| title | Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients |
| title_full | Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients |
| title_fullStr | Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients |
| title_full_unstemmed | Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients |
| title_short | Health-related quality of life profile in relation to chemotherapy-induced nausea and vomiting among breast cancer patients |
| title_sort | health related quality of life profile in relation to chemotherapy induced nausea and vomiting among breast cancer patients |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/18737/6/Health_Related_Quality_of_Life_Profile.pdf http://irep.iium.edu.my/18737/8/Suhana_ASEAN_87-292-1-RV.pdf |
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