Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus
ABSTRACT Background: Dichlorodiphenyl trichioroetane (DDT), polychlorinated biphenyl (PCB) and polybrominated biphenyl (PBB) are carcinogenic substances and significantly decreased liver vitamin A in the animal studies. Liver vitamin A is influenced by dietary vitamin A and the condition of the live...
| Main Author: | |
|---|---|
| Format: | Article |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
1999
|
| Subjects: |
| _version_ | 1826031770356678656 |
|---|---|
| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | ABSTRACT
Background: Dichlorodiphenyl trichioroetane (DDT), polychlorinated biphenyl (PCB) and polybrominated biphenyl (PBB) are carcinogenic substances and significantly decreased liver vitamin A in the animal studies. Liver vitamin A is influenced by dietary vitamin A and the condition of the liver. Aflatoxin Bi is a carcinogenic substance like DDT, PCB and PBB. Aflatoxin Bi is the environmental exposures problem in several tropical -countries and liver are the main organ targets of the carcinogenicity of aflatoxin Bi.
Objective: To provide more extensive description of the effects of dietary vitamin A (deficient, adequate, fourfold adequate) against the effect of aflatoxin Bi (AFBi) on the vitamin A status of rats.
Methods: Vitamin A status of animals was demonstrated by concentrations of liver and serum vitamin A. The subjects consisted of fourty eight male Rattus norvegicus rats in good general condition, 1-2 months old with body weight around 62-68.5 grams, were randomly divided into 12 groups of four rats each. Rats in group I to
VI which were killed at the start of the experiment and were used as the initial condition of liver and serum vitamin A concentrations for the rats in group VII to XII. Vitamin A-deficient diets were given to rats in group
VII and VIII. Vitamin A-adequate diets were given to rats in group IX and X, while vitamin A-fourfold adequate diets were given to rats in group XI and XII. Rats in group VIII, X and XII were orally treated by an aplicator with 15g of AFB� in 0.2 ml of propylene glycol everyday for 16 weeks. While rats in group VII, IX and XI were treated without AFB�.
Results: By analysis of variance, the results showed that the effects of interaction of dietary vitamin A and AFBi demonstrated a very significant effect (p |
| first_indexed | 2024-03-05T22:58:57Z |
| format | Article |
| id | oai:generic.eprints.org:20939 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T18:42:32Z |
| publishDate | 1999 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:209392014-06-18T00:35:49Z https://repository.ugm.ac.id/20939/ Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus Perpustakaan UGM, i-lib Jurnal i-lib UGM ABSTRACT Background: Dichlorodiphenyl trichioroetane (DDT), polychlorinated biphenyl (PCB) and polybrominated biphenyl (PBB) are carcinogenic substances and significantly decreased liver vitamin A in the animal studies. Liver vitamin A is influenced by dietary vitamin A and the condition of the liver. Aflatoxin Bi is a carcinogenic substance like DDT, PCB and PBB. Aflatoxin Bi is the environmental exposures problem in several tropical -countries and liver are the main organ targets of the carcinogenicity of aflatoxin Bi. Objective: To provide more extensive description of the effects of dietary vitamin A (deficient, adequate, fourfold adequate) against the effect of aflatoxin Bi (AFBi) on the vitamin A status of rats. Methods: Vitamin A status of animals was demonstrated by concentrations of liver and serum vitamin A. The subjects consisted of fourty eight male Rattus norvegicus rats in good general condition, 1-2 months old with body weight around 62-68.5 grams, were randomly divided into 12 groups of four rats each. Rats in group I to VI which were killed at the start of the experiment and were used as the initial condition of liver and serum vitamin A concentrations for the rats in group VII to XII. Vitamin A-deficient diets were given to rats in group VII and VIII. Vitamin A-adequate diets were given to rats in group IX and X, while vitamin A-fourfold adequate diets were given to rats in group XI and XII. Rats in group VIII, X and XII were orally treated by an aplicator with 15g of AFB� in 0.2 ml of propylene glycol everyday for 16 weeks. While rats in group VII, IX and XI were treated without AFB�. Results: By analysis of variance, the results showed that the effects of interaction of dietary vitamin A and AFBi demonstrated a very significant effect (p [Yogyakarta] : Universitas Gadjah Mada 1999 Article NonPeerReviewed Perpustakaan UGM, i-lib (1999) Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=3797 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus |
| title | Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus |
| title_full | Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus |
| title_fullStr | Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus |
| title_full_unstemmed | Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus |
| title_short | Pengaruh kandungan vitamin A diet terhadap efek aflatoksin Bi pada status vitamin A tikus Rattus norvegicus |
| title_sort | pengaruh kandungan vitamin a diet terhadap efek aflatoksin bi pada status vitamin a tikus rattus norvegicus |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib pengaruhkandunganvitaminadietterhadapefekaflatoksinbipadastatusvitaminatikusrattusnorvegicus |