| Summary: | ABSTRACT
Background: According to the fact, there is chance that the Zingiber officinale volatile oil can be developed for treatment elephantiasis in man. However, up to now there was no study yet on the efficacy of the phytopharmaca against filaria.
Objective: The clinical trial was designed to know the effect and the safety of application of Zingiber officinale volatile oil as anti-filariasis agent in the treatment of Brugia malayi infection in Kalimantan area.
Methods: In this study, 40 patients suffered from filariasis malayi were divided into 2 groups. Zingiber officinale volatile oil in honey syrup was given to each patient of group I. Honey syrup as plasebo was given to each patient of group II. The treatment was given for 28 consecutive days each. The density of microfilariae before and after treatment of each group were recorded and assessed using Pre-test and Post-test by using probit analysis.
Results: This study showed' that the average value of microfilaria density before and after treatment count per 60 ul blood in placebo group were 64.9 ± 96.4 and 90.4 ± 122.0. While in volatile oil's group were, 92.1 ± 118.3 and 56.6 ± 77.0 respectively. MfD50 of placebo group before and after treatment is 27.75, and 44.99. MfDso of volatile oil's group before and after treatment is 44.42, and 37.06.
Conclusion: Zingiber officinale volatile oil can be developed for treatment elephantiasis in man.
Key words : microfilaria density - phytopharmaca - volatile oil - filariasis malayi - elephantiasis.
Latar belakang: Dari penelitian-penelitian terdahulu diketahui bahwa minyak atsiri jahe dapat dikembangkan untuk pengobatan filariasis pada manusia.
Tujuan penelitian: Untuk mengetahui efek pemberian minyak atsiri jahe sebagai anti-filariasis pada penderita filariasis malayi di daerah Kalimantan.
Bahan dan cara penelitian: Empat puluh orang penderita filariasis malayi dibagi menjadi 2 kelompok. Kelompok I diberi minyak atsiri jahe dalam sirup madu dan kelompok II hanya diberi sirup madu (plasebo�, masing-masing selama 28 hari berturut-turut. Kepadatan mikrofilaria sebelum dan sesudah perlakuan pada masing-masing kelompok dihitung dan dianalisis dengan probit.
Hasil penelitian: Rerata kepadatan mikrofilaria per 60 ul darah sebelum dan sesudah perlakuan pada kelompok plasebo 64,9 ± 96,4 dan 90,4 ± 122,0. Adapun pada kelompok minyak atsiri jahe 92,1 ± 118,3 dan 56,6 ± 77. MfD50 kelompok plasebo sebelum dan sesudah perlakuan 27,75, dan 44,99. MfD50 kelompok minyak atsiri jahe sebelum dan sesudah perlakuan 44,42, dan 37,06.
Simpulan: Minyak atsiri jahe dapat dikembangkan sebagai obat anti-filariasis.
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