PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND
The solid dispersion method can be used to improve the dissolution properties and bioavailability of poorly water soluble drugs. We have applied this technology to dexamethasone by solvent evaporation method. In order to investigate the physical properties and dissolution rate of dexamethasone table...
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[Yogyakarta] : Universitas Gadjah Mada
1999
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| _version_ | 1797018464969293824 |
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| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | The solid dispersion method can be used to improve the dissolution properties and
bioavailability of poorly water soluble drugs. We have applied this technology to dexamethasone by solvent evaporation method.
In order to investigate the physical properties and dissolution rate of dexamethasone
tablets, with hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC) as solid dispersion systems, the study had been carried out.
These two formulas showed no significant differences in the physical properties. However the dissolution rate of tablets made up using hydroxypropyl cellulose as solid dispersion carrier seemed to be higher than that of the hydroxypropyl methyl cellulose. The high dissolution rate was likely due to methyl substitution on hydroxypropyl methyl cellulose structure.
Keywords : Cellulose derivates. solid dispersion, dexamethasone, dissolution rate |
| first_indexed | 2024-03-05T23:00:21Z |
| format | Article |
| id | oai:generic.eprints.org:21514 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-05T23:00:21Z |
| publishDate | 1999 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:215142014-06-18T00:35:34Z https://repository.ugm.ac.id/21514/ PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND Perpustakaan UGM, i-lib Jurnal i-lib UGM The solid dispersion method can be used to improve the dissolution properties and bioavailability of poorly water soluble drugs. We have applied this technology to dexamethasone by solvent evaporation method. In order to investigate the physical properties and dissolution rate of dexamethasone tablets, with hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC) as solid dispersion systems, the study had been carried out. These two formulas showed no significant differences in the physical properties. However the dissolution rate of tablets made up using hydroxypropyl cellulose as solid dispersion carrier seemed to be higher than that of the hydroxypropyl methyl cellulose. The high dissolution rate was likely due to methyl substitution on hydroxypropyl methyl cellulose structure. Keywords : Cellulose derivates. solid dispersion, dexamethasone, dissolution rate [Yogyakarta] : Universitas Gadjah Mada 1999 Article NonPeerReviewed Perpustakaan UGM, i-lib (1999) PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=4378 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND |
| title | PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND |
| title_full | PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND |
| title_fullStr | PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND |
| title_full_unstemmed | PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND |
| title_short | PENGARUH DUA TURUNAN SELULOSA SEBAGAI PEMBAWA DISPERSI PADAT PADA SWAT FISIS DAN LAJU PELARUTAN SEDIAAN TABLET DEKSAMETASON (THE EFFECT OF TWO CELLULOSE DERIYATES AS SOLID DISPERSION CARRIERS ON PHYSICA L PROPERTIES AND |
| title_sort | pengaruh dua turunan selulosa sebagai pembawa dispersi padat pada swat fisis dan laju pelarutan sediaan tablet deksametason the effect of two cellulose deriyates as solid dispersion carriers on physica l properties and |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib pengaruhduaturunanselulosasebagaipembawadispersipadatpadaswatfisisdanlajupelarutansediaantabletdeksametasontheeffectoftwocellulosederiyatesassoliddispersioncarriersonphysicalpropertiesand |