Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partiall...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IIUM Press
2011
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/23413/1/Noraini_et_al_correct.pdf |
| _version_ | 1825646532354899968 |
|---|---|
| author | Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah |
| author_facet | Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah |
| author_sort | Mohd Yusoff, Noraini |
| collection | IIUM |
| description | Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7
was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates
degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration.
|
| first_indexed | 2024-03-05T23:03:58Z |
| format | Article |
| id | oai:generic.eprints.org:23413 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:03:58Z |
| publishDate | 2011 |
| publisher | IIUM Press |
| record_format | dspace |
| spelling | oai:generic.eprints.org:234132021-07-06T02:17:17Z http://irep.iium.edu.my/23413/ Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah T175 Industrial research. Research and development TP248.13 Biotechnology Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration. IIUM Press 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23413/1/Noraini_et_al_correct.pdf Mohd Yusoff, Noraini and Nuge, Tamrin and Zainan, Nor Hidayah and Hashim, Yumi Zuhanis Has-Yun and Jamal, Parveen and Meor Hussin, Anis Shobirin and Farouk Gad, Abd. El-Aziem and Mohd. Salleh, Hamzah (2011) Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. IIUM Engineering Journal, 12 (4). pp. 141-151. ISSN 1511-788X |
| spellingShingle | T175 Industrial research. Research and development TP248.13 Biotechnology Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
| title | Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
| title_full | Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
| title_fullStr | Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
| title_full_unstemmed | Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
| title_short | Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
| title_sort | preliminary investigation of myo inositol phosphates produced by asuia279phytase on mcf 7 cancer cells |
| topic | T175 Industrial research. Research and development TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/23413/1/Noraini_et_al_correct.pdf |
| work_keys_str_mv | AT mohdyusoffnoraini preliminaryinvestigationofmyoinositolphosphatesproducedbyasuia279phytaseonmcf7cancercells AT nugetamrin preliminaryinvestigationofmyoinositolphosphatesproducedbyasuia279phytaseonmcf7cancercells AT zainannorhidayah preliminaryinvestigationofmyoinositolphosphatesproducedbyasuia279phytaseonmcf7cancercells AT hashimyumizuhanishasyun preliminaryinvestigationofmyoinositolphosphatesproducedbyasuia279phytaseonmcf7cancercells AT jamalparveen preliminaryinvestigationofmyoinositolphosphatesproducedbyasuia279phytaseonmcf7cancercells AT meorhussinanisshobirin preliminaryinvestigationofmyoinositolphosphatesproducedbyasuia279phytaseonmcf7cancercells AT faroukgadabdelaziem preliminaryinvestigationofmyoinositolphosphatesproducedbyasuia279phytaseonmcf7cancercells AT mohdsallehhamzah preliminaryinvestigationofmyoinositolphosphatesproducedbyasuia279phytaseonmcf7cancercells |