Age-related rarefaction in the fractal dimension of retinal vessel
Previous work suggests a general reduction in complexity with aging, referred to as the aging-complexity theory. Fractal dimension (FD) of the vessels in the retina is a global measure of the complexity of the vasculature. However, earlier works did not find any correlation between aging and FD of t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Inc.
2012
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| Online Access: | http://irep.iium.edu.my/24913/1/Age-related_rarefaction_in_Fractal_Dimension_of_retinal_vasculature.pdf |
| _version_ | 1825646690396274688 |
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| author | Che Azemin, Mohd Zulfaezal Kumar, Dinesh Kant Wong, Tien Y. Wang, Jie Jin Mitchell, Paul Kawasaki, Ryo Wu, Henry |
| author_facet | Che Azemin, Mohd Zulfaezal Kumar, Dinesh Kant Wong, Tien Y. Wang, Jie Jin Mitchell, Paul Kawasaki, Ryo Wu, Henry |
| author_sort | Che Azemin, Mohd Zulfaezal |
| collection | IIUM |
| description | Previous work suggests a general reduction in complexity with aging, referred to as the aging-complexity theory. Fractal dimension (FD) of the vessels in the retina is a global measure of the complexity of the vasculature. However, earlier works did not find any correlation between aging and FD of the retinal vasculature, in contrast to the findings of reduced complexity in other parts of the body. The authors tested the hypothesis that reduced complexity develops with advancing age in the structure of the retinal vasculature. To overcome the limitations of earlier works, a three-dimensional representation of the vasculature, together with Fourier fractal dimension (FFD) techniques, was used. Based on the analysis of 748 retinal images taken of persons aged 49-89 years, we observed a significant decrease in the FFD with aging (p < 0.0001). These data provide evidence supporting rarefaction (i.e. reduction) of the retinal vasculature with aging, consistent with observations from other human organ systems. |
| first_indexed | 2024-03-05T23:06:21Z |
| format | Article |
| id | oai:generic.eprints.org:24913 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T23:06:21Z |
| publishDate | 2012 |
| publisher | Elsevier Inc. |
| record_format | dspace |
| spelling | oai:generic.eprints.org:249132022-06-30T08:15:32Z http://irep.iium.edu.my/24913/ Age-related rarefaction in the fractal dimension of retinal vessel Che Azemin, Mohd Zulfaezal Kumar, Dinesh Kant Wong, Tien Y. Wang, Jie Jin Mitchell, Paul Kawasaki, Ryo Wu, Henry RE Ophthalmology Previous work suggests a general reduction in complexity with aging, referred to as the aging-complexity theory. Fractal dimension (FD) of the vessels in the retina is a global measure of the complexity of the vasculature. However, earlier works did not find any correlation between aging and FD of the retinal vasculature, in contrast to the findings of reduced complexity in other parts of the body. The authors tested the hypothesis that reduced complexity develops with advancing age in the structure of the retinal vasculature. To overcome the limitations of earlier works, a three-dimensional representation of the vasculature, together with Fourier fractal dimension (FFD) techniques, was used. Based on the analysis of 748 retinal images taken of persons aged 49-89 years, we observed a significant decrease in the FFD with aging (p < 0.0001). These data provide evidence supporting rarefaction (i.e. reduction) of the retinal vasculature with aging, consistent with observations from other human organ systems. Elsevier Inc. 2012-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24913/1/Age-related_rarefaction_in_Fractal_Dimension_of_retinal_vasculature.pdf Che Azemin, Mohd Zulfaezal and Kumar, Dinesh Kant and Wong, Tien Y. and Wang, Jie Jin and Mitchell, Paul and Kawasaki, Ryo and Wu, Henry (2012) Age-related rarefaction in the fractal dimension of retinal vessel. Neurobiology of Aging, 33 (1). 194.e1-194.e4. ISSN 0197-4580 http://www.sciencedirect.com/science/journal/01974580 10.1016/j.neurobiolaging.2010.04.010 |
| spellingShingle | RE Ophthalmology Che Azemin, Mohd Zulfaezal Kumar, Dinesh Kant Wong, Tien Y. Wang, Jie Jin Mitchell, Paul Kawasaki, Ryo Wu, Henry Age-related rarefaction in the fractal dimension of retinal vessel |
| title | Age-related rarefaction in the fractal dimension of retinal vessel |
| title_full | Age-related rarefaction in the fractal dimension of retinal vessel |
| title_fullStr | Age-related rarefaction in the fractal dimension of retinal vessel |
| title_full_unstemmed | Age-related rarefaction in the fractal dimension of retinal vessel |
| title_short | Age-related rarefaction in the fractal dimension of retinal vessel |
| title_sort | age related rarefaction in the fractal dimension of retinal vessel |
| topic | RE Ophthalmology |
| url | http://irep.iium.edu.my/24913/1/Age-related_rarefaction_in_Fractal_Dimension_of_retinal_vasculature.pdf |
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