Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals
Background: The establishment of macrovascular (cardiovascular) event is initiated in the period of prediabetic. Metformin plays role in the carbohydrate and lipid metabolism as well as vascular protection. The mechanism of the cardiovascular event risk increased in the pre-diabetic individual has n...
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| Format: | Article |
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[Yogyakarta] : Universitas Gadjah Mada
2008
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| _version_ | 1797019690551214080 |
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| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | Background: The establishment of macrovascular (cardiovascular) event is initiated in the period of prediabetic. Metformin plays role in the carbohydrate and lipid metabolism as well as vascular protection. The mechanism of the cardiovascular event risk increased in the pre-diabetic individual has not been clearly established.
Objective: The study was to determine if insulin resistance control by low-dose short-course metformin administration in the non-obese prediabetic individual might decrease the risk of atherosclerosis.
Methods: It was a prospective experimental double blind study with pretest-posttest control group design. It was conducted on the first degree relatives of type-2 Diabetes Mellitus patients who met the criteria of non-obese prediabetic individuals. Subjects were randomly classified into treatment group (designed for metformin administration), and the control group (designed for placebo administration). The prediction of atherosclerosis risk was based on the hsCRP, PAI-1, VCAM-1, and fibrinogen levels.
Result: The results showed that the margin between pre- and post-metformin administration term were 1.89 vs. 0.06 mg/L (p=0.001), 1.42 vs. 0.84 IU/mL (p=0.0151. 180.85 vs. 03.81 mg/L (p=0.061) and 80.15 vs. 31.42 mg/dL (p=0.001) for hsCRP, PAI-1, VCAM-1, and Fibrinogen levels in the treatment and control group, respectively.
Conclusion: The study concluded that the low-dose short-course metformin administration might decrease the atherosclerosis risk significantly in the non-obese prediabetic individuals.
Key words: metformin - non-obese prediabetics - hsCRP - PAI-T- Fibrinogen - VCAM-T |
| first_indexed | 2024-03-05T23:10:59Z |
| format | Article |
| id | oai:generic.eprints.org:27441 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T19:03:33Z |
| publishDate | 2008 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:274412014-06-18T00:24:58Z https://repository.ugm.ac.id/27441/ Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals Perpustakaan UGM, i-lib Jurnal i-lib UGM Background: The establishment of macrovascular (cardiovascular) event is initiated in the period of prediabetic. Metformin plays role in the carbohydrate and lipid metabolism as well as vascular protection. The mechanism of the cardiovascular event risk increased in the pre-diabetic individual has not been clearly established. Objective: The study was to determine if insulin resistance control by low-dose short-course metformin administration in the non-obese prediabetic individual might decrease the risk of atherosclerosis. Methods: It was a prospective experimental double blind study with pretest-posttest control group design. It was conducted on the first degree relatives of type-2 Diabetes Mellitus patients who met the criteria of non-obese prediabetic individuals. Subjects were randomly classified into treatment group (designed for metformin administration), and the control group (designed for placebo administration). The prediction of atherosclerosis risk was based on the hsCRP, PAI-1, VCAM-1, and fibrinogen levels. Result: The results showed that the margin between pre- and post-metformin administration term were 1.89 vs. 0.06 mg/L (p=0.001), 1.42 vs. 0.84 IU/mL (p=0.0151. 180.85 vs. 03.81 mg/L (p=0.061) and 80.15 vs. 31.42 mg/dL (p=0.001) for hsCRP, PAI-1, VCAM-1, and Fibrinogen levels in the treatment and control group, respectively. Conclusion: The study concluded that the low-dose short-course metformin administration might decrease the atherosclerosis risk significantly in the non-obese prediabetic individuals. Key words: metformin - non-obese prediabetics - hsCRP - PAI-T- Fibrinogen - VCAM-T [Yogyakarta] : Universitas Gadjah Mada 2008 Article NonPeerReviewed Perpustakaan UGM, i-lib (2008) Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=10500 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals |
| title | Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals |
| title_full | Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals |
| title_fullStr | Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals |
| title_full_unstemmed | Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals |
| title_short | Low-dose short-course metformin decrease the risk of atherosclerosis in the non-obese prediabetic individuals |
| title_sort | low dose short course metformin decrease the risk of atherosclerosis in the non obese prediabetic individuals |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib lowdoseshortcoursemetformindecreasetheriskofatherosclerosisinthenonobeseprediabeticindividuals |