Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based and Its In-vitro Antibacterial Test
Pyrazoline has been reported with a broad spectrum of biological activity. The presence of the withdrawing group especially the 4-nitrophenyl group in the 3 th ring of pyrazoline has never been performed. A new derivative of 2- pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly,...
| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/278574/1/Wahyuningsih_MA.pdf |
| Summary: | Pyrazoline has been reported with a broad spectrum of biological activity. The presence of the withdrawing
group especially the 4-nitrophenyl group in the 3 th ring of pyrazoline has never been performed. A new derivative of 2-
pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly, pyrazoline was synthesized by cyclization of
chalcone and hydrazine hydrate without acetate acid as a catalyst. Reactants were refluxed for 30 hours and controlled by Thin Layer Chromatography (TLC). The result showed that the reaction yielded 45.07% red solid pyrazoline. Characterization of the structure was confirmed by FTIR and 1H- NMR spectra. However, in vitro antibacterial study showed that the compound has very low antibacterial activity. |
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