Asymptomatic Cryptosporidiosis in Children Living with HIV
Children living with human immunodeficiency virus (HIV) have an increased risk of opportunistic Cryptosporidium infection. Cryptosporidium usually causes chronic diarrhea that may lead to impaired growth and cognitive function in children. This study aimed to estimate the prevalence of cryptosporidi...
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| Format: | Article |
| Language: | English |
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MDPI
2022
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| Online Access: | https://repository.ugm.ac.id/278702/1/Diptyanusa_KKMK.pdf |
| _version_ | 1797037333261844480 |
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| author | Diptyanusa, Ajib Sari, Ika Puspa Kurniawan, Agnes |
| author_facet | Diptyanusa, Ajib Sari, Ika Puspa Kurniawan, Agnes |
| author_sort | Diptyanusa, Ajib |
| collection | UGM |
| description | Children living with human immunodeficiency virus (HIV) have an increased risk of opportunistic Cryptosporidium infection. Cryptosporidium usually causes chronic diarrhea that may lead to impaired growth and cognitive function in children. This study aimed to estimate the prevalence of cryptosporidiosis in children, describe its clinical characteristics, and the risk factors. A cross-sectional study involving children aged 6 months to 18 years old with confirmed HIV infection was carried out in Sardjito General Hospital, Yogyakarta. Diagnosis of cryptosporidiosis was made by PCR of 18S rRNA after being screened by microscopic examination. The clinical characteristics and risk factors were obtained from medical records and structured questionnaires. A total of 52 participants were included in the final analysis. The prevalence of cryptosporidiosis was 42.3%. Approximately 68% of the HIV children with cryptosporidiosis were asymptomatic, while those who
reported symptoms showed weight loss and diarrhea. Independent risk factors of cryptosporidiosis were diarrhea (AOR 6.5; 95% CI 1.16–36.67), well water as drinking water source (AOR 6.7; 95% CI 1.83–24.93), and drink untreated water (AOR 5.8; 95% CI 1.04–32.64). A high prevalence of
asymptomatic cryptosporidiosis was observed among children with HIV infection and PCR screening of Cryptosporidium in high-risk children is advisable. |
| first_indexed | 2024-03-14T00:01:53Z |
| format | Article |
| id | oai:generic.eprints.org:278702 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:01:53Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2787022023-11-02T00:51:52Z https://repository.ugm.ac.id/278702/ Asymptomatic Cryptosporidiosis in Children Living with HIV Diptyanusa, Ajib Sari, Ika Puspa Kurniawan, Agnes Clinical Sciences Children living with human immunodeficiency virus (HIV) have an increased risk of opportunistic Cryptosporidium infection. Cryptosporidium usually causes chronic diarrhea that may lead to impaired growth and cognitive function in children. This study aimed to estimate the prevalence of cryptosporidiosis in children, describe its clinical characteristics, and the risk factors. A cross-sectional study involving children aged 6 months to 18 years old with confirmed HIV infection was carried out in Sardjito General Hospital, Yogyakarta. Diagnosis of cryptosporidiosis was made by PCR of 18S rRNA after being screened by microscopic examination. The clinical characteristics and risk factors were obtained from medical records and structured questionnaires. A total of 52 participants were included in the final analysis. The prevalence of cryptosporidiosis was 42.3%. Approximately 68% of the HIV children with cryptosporidiosis were asymptomatic, while those who reported symptoms showed weight loss and diarrhea. Independent risk factors of cryptosporidiosis were diarrhea (AOR 6.5; 95% CI 1.16–36.67), well water as drinking water source (AOR 6.7; 95% CI 1.83–24.93), and drink untreated water (AOR 5.8; 95% CI 1.04–32.64). A high prevalence of asymptomatic cryptosporidiosis was observed among children with HIV infection and PCR screening of Cryptosporidium in high-risk children is advisable. MDPI 2022-11-04 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/278702/1/Diptyanusa_KKMK.pdf Diptyanusa, Ajib and Sari, Ika Puspa and Kurniawan, Agnes (2022) Asymptomatic Cryptosporidiosis in Children Living with HIV. Trop. Med. Infect. Dis., 2022 (7). pp. 1-11. ISSN 2414-6366 https://www.mdpi.com/journal/tropicalmed https://doi.org/10.3390/tropicalmed7110352 |
| spellingShingle | Clinical Sciences Diptyanusa, Ajib Sari, Ika Puspa Kurniawan, Agnes Asymptomatic Cryptosporidiosis in Children Living with HIV |
| title | Asymptomatic Cryptosporidiosis in Children Living with HIV |
| title_full | Asymptomatic Cryptosporidiosis in Children Living with HIV |
| title_fullStr | Asymptomatic Cryptosporidiosis in Children Living with HIV |
| title_full_unstemmed | Asymptomatic Cryptosporidiosis in Children Living with HIV |
| title_short | Asymptomatic Cryptosporidiosis in Children Living with HIV |
| title_sort | asymptomatic cryptosporidiosis in children living with hiv |
| topic | Clinical Sciences |
| url | https://repository.ugm.ac.id/278702/1/Diptyanusa_KKMK.pdf |
| work_keys_str_mv | AT diptyanusaajib asymptomaticcryptosporidiosisinchildrenlivingwithhiv AT sariikapuspa asymptomaticcryptosporidiosisinchildrenlivingwithhiv AT kurniawanagnes asymptomaticcryptosporidiosisinchildrenlivingwithhiv |