Editorial: Development, assessment, improvement, and standardization of methods in herbal drug research
Herbal drugs (HDs) or herbal medicines have been applied for a very long time as natural remedies for preventing and curing diseases and for improving human health. HDs are currently gaining increasing popularity globally as drugs, complementary and alternative medicines, nutraceuticals, food supple...
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| Format: | Article |
| Language: | English |
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Frontier
2022
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| Online Access: | https://repository.ugm.ac.id/278722/1/Rohman_KKMK.pdf |
| _version_ | 1797037346618605568 |
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| author | Rohman, Abdul Indrayanto, Gunawan Ingkaninan, Kornkanok |
| author_facet | Rohman, Abdul Indrayanto, Gunawan Ingkaninan, Kornkanok |
| author_sort | Rohman, Abdul |
| collection | UGM |
| description | Herbal drugs (HDs) or herbal medicines have been applied for a very long time as natural remedies for preventing and curing diseases and for improving human health. HDs are currently gaining increasing popularity globally as drugs, complementary and alternative medicines, nutraceuticals, food supplements, and cosmetics. HDs have gained wider interest among societies during the past decades due to their broad, synergistic actions on the physiological systems and the relatively lower incidence of adverse events compared to synthetic drugs (Noviana et al.). However, HD may not be entirely safe because some studies have reported adverse effects such as nephrotoxicity, hepatotoxicity, cardiotoxicity, neurotoxicity, and skin toxicity during the administration of HDs. These adverse effects may be due to the presence of some toxic metabolites or contaminants such as aflatoxins, or due to the falsification of HDs. Therefore, the quality assurance and authenticity of HDs must be assured (Heinrich, 2015). The complexity of HDs, which typically consist of many constituents, has raised major quality issues. The bioactive compounds of extracts and/or HD preparation are typically very complex and may vary. Thus, if the exact chemical composition is not determined accurately and specifically, the reported bioactivity or pharmacological effects may not always be reproducible. Assuring high-quality HDs with reproducible quality, efficacy, and safety is a challenging task. As a consequence, the availability of appropriate analytical methods is highly required, not only for the identification and standardization of HDs but also for the detection of adulterants and contaminants (Muyumba et al., 2021). The analytical methods used for the quality control of HDs, either chemical or biological-based methods, must be official methods. Otherwise, the methods should first be validated according to the latest official guidelines. Without analytical method validation, the reliability of the data cannot be confirmed, and the results would be difficult to replicate by other scientists (Indrayanto, 2022). |
| first_indexed | 2024-03-14T00:01:56Z |
| format | Article |
| id | oai:generic.eprints.org:278722 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:01:56Z |
| publishDate | 2022 |
| publisher | Frontier |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2787222023-10-06T06:24:48Z https://repository.ugm.ac.id/278722/ Editorial: Development, assessment, improvement, and standardization of methods in herbal drug research Rohman, Abdul Indrayanto, Gunawan Ingkaninan, Kornkanok Pharmacology and Pharmaceutical Sciences Herbal drugs (HDs) or herbal medicines have been applied for a very long time as natural remedies for preventing and curing diseases and for improving human health. HDs are currently gaining increasing popularity globally as drugs, complementary and alternative medicines, nutraceuticals, food supplements, and cosmetics. HDs have gained wider interest among societies during the past decades due to their broad, synergistic actions on the physiological systems and the relatively lower incidence of adverse events compared to synthetic drugs (Noviana et al.). However, HD may not be entirely safe because some studies have reported adverse effects such as nephrotoxicity, hepatotoxicity, cardiotoxicity, neurotoxicity, and skin toxicity during the administration of HDs. These adverse effects may be due to the presence of some toxic metabolites or contaminants such as aflatoxins, or due to the falsification of HDs. Therefore, the quality assurance and authenticity of HDs must be assured (Heinrich, 2015). The complexity of HDs, which typically consist of many constituents, has raised major quality issues. The bioactive compounds of extracts and/or HD preparation are typically very complex and may vary. Thus, if the exact chemical composition is not determined accurately and specifically, the reported bioactivity or pharmacological effects may not always be reproducible. Assuring high-quality HDs with reproducible quality, efficacy, and safety is a challenging task. As a consequence, the availability of appropriate analytical methods is highly required, not only for the identification and standardization of HDs but also for the detection of adulterants and contaminants (Muyumba et al., 2021). The analytical methods used for the quality control of HDs, either chemical or biological-based methods, must be official methods. Otherwise, the methods should first be validated according to the latest official guidelines. Without analytical method validation, the reliability of the data cannot be confirmed, and the results would be difficult to replicate by other scientists (Indrayanto, 2022). Frontier 2022-11-16 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/278722/1/Rohman_KKMK.pdf Rohman, Abdul and Indrayanto, Gunawan and Ingkaninan, Kornkanok (2022) Editorial: Development, assessment, improvement, and standardization of methods in herbal drug research. Frontiers in Medicine, 2022 (13). pp. 1-4. ISSN 2296-701X https://www.frontiersin.org/articles/10.3389/fphar.2022.1071194/full https://doi.org/10.3389/fphar.2022.1071194 |
| spellingShingle | Pharmacology and Pharmaceutical Sciences Rohman, Abdul Indrayanto, Gunawan Ingkaninan, Kornkanok Editorial: Development, assessment, improvement, and standardization of methods in herbal drug research |
| title | Editorial: Development, assessment, improvement, and
standardization of methods in herbal drug research |
| title_full | Editorial: Development, assessment, improvement, and
standardization of methods in herbal drug research |
| title_fullStr | Editorial: Development, assessment, improvement, and
standardization of methods in herbal drug research |
| title_full_unstemmed | Editorial: Development, assessment, improvement, and
standardization of methods in herbal drug research |
| title_short | Editorial: Development, assessment, improvement, and
standardization of methods in herbal drug research |
| title_sort | editorial development assessment improvement and standardization of methods in herbal drug research |
| topic | Pharmacology and Pharmaceutical Sciences |
| url | https://repository.ugm.ac.id/278722/1/Rohman_KKMK.pdf |
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