In vitro antiplasmodial activities of the fractions of Hyrtios reticulatus sponge extract
The discovery of new compounds sourced from nature, which are active against malaria, is very important. Sponge Hyrtios reticulatus from Bali, Indonesia, is one of the examples that can be investigated. The sponge samples were extracted using ethanol, followed by trituration fractionation and vacu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Open Science Publishers LLP
2022
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/278818/1/Mahfur_FA.pdf |
| _version_ | 1826050327762173952 |
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| author | Mahfur, Mahfur Wahyuono, Subagus Purwantini, Indah Setyowati, Erna Prawita |
| author_facet | Mahfur, Mahfur Wahyuono, Subagus Purwantini, Indah Setyowati, Erna Prawita |
| author_sort | Mahfur, Mahfur |
| collection | UGM |
| description | The discovery of new compounds sourced from nature, which are active against malaria, is very important. Sponge
Hyrtios reticulatus from Bali, Indonesia, is one of the examples that can be investigated. The sponge samples were
extracted using ethanol, followed by trituration fractionation and vacuum liquid chromatography to get the samples. The nine samples obtained, their main extracts, chloroform fraction, residue, and SF 1–9 were tested for activities against Plasmodium falciparum variants 3D7 and FCR3. The results showed that all samples had a moderate
antiplasmodial activity, where the most active sample was SF 3 with an IC50 of 12.98 ± 1.88 μg/ml on 3D7 and 19.81 ± 0.75 μg/ml on FCR3. This study discovered that H. reticulatus sponges had antiplasmodial activities and could be further used as a guide to finding a new antiplasmodial compound. |
| first_indexed | 2024-03-14T00:02:13Z |
| format | Article |
| id | oai:generic.eprints.org:278818 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:02:13Z |
| publishDate | 2022 |
| publisher | Open Science Publishers LLP |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2788182023-11-02T00:24:24Z https://repository.ugm.ac.id/278818/ In vitro antiplasmodial activities of the fractions of Hyrtios reticulatus sponge extract Mahfur, Mahfur Wahyuono, Subagus Purwantini, Indah Setyowati, Erna Prawita Pharmaceutical Sciences The discovery of new compounds sourced from nature, which are active against malaria, is very important. Sponge Hyrtios reticulatus from Bali, Indonesia, is one of the examples that can be investigated. The sponge samples were extracted using ethanol, followed by trituration fractionation and vacuum liquid chromatography to get the samples. The nine samples obtained, their main extracts, chloroform fraction, residue, and SF 1–9 were tested for activities against Plasmodium falciparum variants 3D7 and FCR3. The results showed that all samples had a moderate antiplasmodial activity, where the most active sample was SF 3 with an IC50 of 12.98 ± 1.88 μg/ml on 3D7 and 19.81 ± 0.75 μg/ml on FCR3. This study discovered that H. reticulatus sponges had antiplasmodial activities and could be further used as a guide to finding a new antiplasmodial compound. Open Science Publishers LLP 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/278818/1/Mahfur_FA.pdf Mahfur, Mahfur and Wahyuono, Subagus and Purwantini, Indah and Setyowati, Erna Prawita (2022) In vitro antiplasmodial activities of the fractions of Hyrtios reticulatus sponge extract. Journal of Applied Pharmaceutical Science, 12 (9). pp. 114-120. ISSN 2231-3354 http://www.japsonline.com https://doi.org/10.7324/JAPS.2022.120913 |
| spellingShingle | Pharmaceutical Sciences Mahfur, Mahfur Wahyuono, Subagus Purwantini, Indah Setyowati, Erna Prawita In vitro antiplasmodial activities of the fractions of Hyrtios reticulatus sponge extract |
| title | In vitro antiplasmodial activities of the fractions of Hyrtios
reticulatus sponge extract |
| title_full | In vitro antiplasmodial activities of the fractions of Hyrtios
reticulatus sponge extract |
| title_fullStr | In vitro antiplasmodial activities of the fractions of Hyrtios
reticulatus sponge extract |
| title_full_unstemmed | In vitro antiplasmodial activities of the fractions of Hyrtios
reticulatus sponge extract |
| title_short | In vitro antiplasmodial activities of the fractions of Hyrtios
reticulatus sponge extract |
| title_sort | in vitro antiplasmodial activities of the fractions of hyrtios reticulatus sponge extract |
| topic | Pharmaceutical Sciences |
| url | https://repository.ugm.ac.id/278818/1/Mahfur_FA.pdf |
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