Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia
Malnutrition, which consists of undernutrition and overnutrition, is associated with gut microbiota composition, diet, and sociodemographic factors. Undernutrition is a nutrient deficiency that that should be identified to prevent other diseases. In this study, we evaluate the gut microbiota composi...
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| Format: | Article |
| Language: | English |
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https://www.mdpi.com/journal/microorganisms
2022
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| Online Access: | https://repository.ugm.ac.id/278823/1/Gut-Microbiota-Composition-in-Undernourished-Children-Associated-with-Diet-and-Sociodemographic-Factors-A-CaseControl-Study-in-IndonesiaMicroorganisms.pdf |
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| author | Gatya, Mifta Fibri, Dwi Larasatie Nur Utami, Tyas Suroto, Dian Anggraini Rahayu, Endang Sutriswati |
| author_facet | Gatya, Mifta Fibri, Dwi Larasatie Nur Utami, Tyas Suroto, Dian Anggraini Rahayu, Endang Sutriswati |
| author_sort | Gatya, Mifta |
| collection | UGM |
| description | Malnutrition, which consists of undernutrition and overnutrition, is associated with gut microbiota composition, diet, and sociodemographic factors. Undernutrition is a nutrient deficiency that that should be identified to prevent other diseases. In this study, we evaluate the gut microbiota composition in undernourished children in association with diet and sociodemographic factors. We observed normal children (n= 20) and undernourished children (n= 20) for ten days in Lombok and Yogyakarta. Diet, sociodemographic factors, and medical records were recorded using food records, screening forms, and standard household questionnaires. Gut microbiota analysis was performed using 16S rRNA gene sequencing targeting the V3–V4 region. The result showed that the undernourished group had lower energy intake. In addition, the undernourished group had lower quality of medical records, parent knowledge, education, and exclusive breastfeeding. Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia were significantly different between normal and undernourished children. Based on LefSe, we determined that Akkermansia is a biomarker for undernourished children. In conclusion, diet and sociodemographic factors affect the gut microbiota composition of undernourished children. |
| first_indexed | 2024-03-14T00:02:14Z |
| format | Article |
| id | oai:generic.eprints.org:278823 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:02:14Z |
| publishDate | 2022 |
| publisher | https://www.mdpi.com/journal/microorganisms |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2788232023-10-16T03:42:53Z https://repository.ugm.ac.id/278823/ Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia Gatya, Mifta Fibri, Dwi Larasatie Nur Utami, Tyas Suroto, Dian Anggraini Rahayu, Endang Sutriswati Sustainable Agricultural Development Other Agricultural and Veterinary Sciences Malnutrition, which consists of undernutrition and overnutrition, is associated with gut microbiota composition, diet, and sociodemographic factors. Undernutrition is a nutrient deficiency that that should be identified to prevent other diseases. In this study, we evaluate the gut microbiota composition in undernourished children in association with diet and sociodemographic factors. We observed normal children (n= 20) and undernourished children (n= 20) for ten days in Lombok and Yogyakarta. Diet, sociodemographic factors, and medical records were recorded using food records, screening forms, and standard household questionnaires. Gut microbiota analysis was performed using 16S rRNA gene sequencing targeting the V3–V4 region. The result showed that the undernourished group had lower energy intake. In addition, the undernourished group had lower quality of medical records, parent knowledge, education, and exclusive breastfeeding. Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia were significantly different between normal and undernourished children. Based on LefSe, we determined that Akkermansia is a biomarker for undernourished children. In conclusion, diet and sociodemographic factors affect the gut microbiota composition of undernourished children. https://www.mdpi.com/journal/microorganisms 2022-08-30 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/278823/1/Gut-Microbiota-Composition-in-Undernourished-Children-Associated-with-Diet-and-Sociodemographic-Factors-A-CaseControl-Study-in-IndonesiaMicroorganisms.pdf Gatya, Mifta and Fibri, Dwi Larasatie Nur and Utami, Tyas and Suroto, Dian Anggraini and Rahayu, Endang Sutriswati (2022) Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia. microorganism, 10 (1748). pp. 1-17. ISSN 20762607 https://www.mdpi.com/journal/microorganisms https://doi.org/10.3390/microorganisms10091748 |
| spellingShingle | Sustainable Agricultural Development Other Agricultural and Veterinary Sciences Gatya, Mifta Fibri, Dwi Larasatie Nur Utami, Tyas Suroto, Dian Anggraini Rahayu, Endang Sutriswati Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia |
| title | Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia |
| title_full | Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia |
| title_fullStr | Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia |
| title_full_unstemmed | Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia |
| title_short | Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case–Control Study in Indonesia |
| title_sort | gut microbiota composition in undernourished children associated with diet and sociodemographic factors a case control study in indonesia |
| topic | Sustainable Agricultural Development Other Agricultural and Veterinary Sciences |
| url | https://repository.ugm.ac.id/278823/1/Gut-Microbiota-Composition-in-Undernourished-Children-Associated-with-Diet-and-Sociodemographic-Factors-A-CaseControl-Study-in-IndonesiaMicroorganisms.pdf |
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