High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia
Objective: Thyroid cancer incidence has steadily increased in Indonesia. However, data on Kirsten rat sarcoma virus (KRAS) and EGFR mutations in thyroid cancer in Indonesia remain unavailable, except for BRAF-V600E, the most common BRAF gene mutation. This study aimed to analyze KRAS and EGFR mutati...
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd
2022
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| Online Access: | https://repository.ugm.ac.id/278879/1/High-frequency-of-KRAS-and-EGFR-mutation-profiles-in-BRAFnegative-thyroid-carcinomas-in-IndonesiaBMC-Research-Notes.pdf |
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| author | Heriyanto, Didik Setyo Laiman, Vincent Limantara, Nikko Vanda Anantawikrama, Widyan Putra Yuliani, Fara Silvia Cempaka, Rita Anwar, Sumadi Lukman |
| author_facet | Heriyanto, Didik Setyo Laiman, Vincent Limantara, Nikko Vanda Anantawikrama, Widyan Putra Yuliani, Fara Silvia Cempaka, Rita Anwar, Sumadi Lukman |
| author_sort | Heriyanto, Didik Setyo |
| collection | UGM |
| description | Objective: Thyroid cancer incidence has steadily increased in Indonesia. However, data on Kirsten rat sarcoma virus (KRAS) and EGFR mutations in thyroid cancer in Indonesia remain unavailable, except for BRAF-V600E, the most common BRAF gene mutation. This study aimed to analyze KRAS and EGFR mutation profiles in BRAF-V600E negative thyroid cancer samples. Results: BRAF-V600E mutations were found in papillary thyroid carcinomas in 40.3% patients with mean age of 53 years old. In BRAF-V600E-negative samples, 41.3% had KRAS mutations with mean age of 55.5 years old. KRAS mutation was found in 52.6% of follicular carcinomas and 47.4% of papillary thyroid carcinomas. Additionally, 45.7% had EGFR mutations in patients with mean age of 50.5 years old. EGFR mutation was found in 71.4% of papillary thyroid carcinoma and 28.6% of follicular carcinoma. Nearly half of the BRAF-V600E negative thyroid carcinoma samples harbored either KRAS or EGFR mutations. This finding suggests that in BRAF-V600E negative thyroid carcinoma samples, testing for RAS and EGFR mutation may be warranted for further therapeutic consideration. |
| first_indexed | 2024-03-14T00:02:24Z |
| format | Article |
| id | oai:generic.eprints.org:278879 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:02:24Z |
| publishDate | 2022 |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2788792023-10-18T05:35:38Z https://repository.ugm.ac.id/278879/ High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia Heriyanto, Didik Setyo Laiman, Vincent Limantara, Nikko Vanda Anantawikrama, Widyan Putra Yuliani, Fara Silvia Cempaka, Rita Anwar, Sumadi Lukman Pathology Cancer Diagnosis Objective: Thyroid cancer incidence has steadily increased in Indonesia. However, data on Kirsten rat sarcoma virus (KRAS) and EGFR mutations in thyroid cancer in Indonesia remain unavailable, except for BRAF-V600E, the most common BRAF gene mutation. This study aimed to analyze KRAS and EGFR mutation profiles in BRAF-V600E negative thyroid cancer samples. Results: BRAF-V600E mutations were found in papillary thyroid carcinomas in 40.3% patients with mean age of 53 years old. In BRAF-V600E-negative samples, 41.3% had KRAS mutations with mean age of 55.5 years old. KRAS mutation was found in 52.6% of follicular carcinomas and 47.4% of papillary thyroid carcinomas. Additionally, 45.7% had EGFR mutations in patients with mean age of 50.5 years old. EGFR mutation was found in 71.4% of papillary thyroid carcinoma and 28.6% of follicular carcinoma. Nearly half of the BRAF-V600E negative thyroid carcinoma samples harbored either KRAS or EGFR mutations. This finding suggests that in BRAF-V600E negative thyroid carcinoma samples, testing for RAS and EGFR mutation may be warranted for further therapeutic consideration. BioMed Central Ltd 2022-12-12 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/278879/1/High-frequency-of-KRAS-and-EGFR-mutation-profiles-in-BRAFnegative-thyroid-carcinomas-in-IndonesiaBMC-Research-Notes.pdf Heriyanto, Didik Setyo and Laiman, Vincent and Limantara, Nikko Vanda and Anantawikrama, Widyan Putra and Yuliani, Fara Silvia and Cempaka, Rita and Anwar, Sumadi Lukman (2022) High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia. BMC Research Notes, 15 (369). pp. 1-6. ISSN 17560500 https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-022-06260-4 https://doi.org/10.1186/s13104-022-06260-4 |
| spellingShingle | Pathology Cancer Diagnosis Heriyanto, Didik Setyo Laiman, Vincent Limantara, Nikko Vanda Anantawikrama, Widyan Putra Yuliani, Fara Silvia Cempaka, Rita Anwar, Sumadi Lukman High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia |
| title | High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia |
| title_full | High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia |
| title_fullStr | High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia |
| title_full_unstemmed | High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia |
| title_short | High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia |
| title_sort | high frequency of kras and egfr mutation profiles in braf negative thyroid carcinomas in indonesia |
| topic | Pathology Cancer Diagnosis |
| url | https://repository.ugm.ac.id/278879/1/High-frequency-of-KRAS-and-EGFR-mutation-profiles-in-BRAFnegative-thyroid-carcinomas-in-IndonesiaBMC-Research-Notes.pdf |
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