A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model

A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic mortality. The objective of this study was to investigate the therapeutic potential of a novel potent histone deacetylase (HDAC) inhibitor MPT0E028 on emphysema. Materials and Methods: A mouse model of porcine pa...

Full description

Bibliographic Details
Main Authors:	Yeh, Lu-Yang, Fang, Yu-Ting, Lee, Hong-Sheng, Liu, Chia-Hao, Chen, You-Yin, Lo, Yu-Chun, Laiman, Vincent, Liou, Jing-Ping, Chung, Kian Fan, Chuang, Hsiao-Chi, Lin, Chien-Huang
Format:	Article
Language:	English
Published:	Frontier 2022
Subjects:	Clinical Sciences
Online Access:	https://repository.ugm.ac.id/278934/1/Laiman_KKMK.pdf

Similar Items

A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model
by: Lu-Yang Yeh, et al.
Published: (2022-05-01)

Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo.
by: Han-Li Huang, et al.
Published: (2012-01-01)

Correction: Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo
Published: (2012-01-01)

Optimization and Development of Selective Histone Deacetylase Inhibitor (MPT0B291)-Loaded Albumin Nanoparticles for Anticancer Therapy
by: Athika Darumas Putri, et al.
Published: (2021-10-01)

Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema
by: Chang, Jer-Hwa, et al.
Published: (2022)

Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema
by: Chang, Jer-Hwa, et al.
Published: (2021)

Correction: The HDAC inhibitor, MPT0E028, enhances erlotinib induced cell death in EGFR-TKI-resistant NSCLC cells
by: M. -C Chen, et al.
Published: (2024-07-01)

Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps
by: Wenli Fan, et al.
Published: (2021-01-01)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
by: Monica Phimmachanh, et al.
Published: (2020-10-01)

Gastric Pneumatosis: Emphysematous Gastritis versus Gastric Emphysema
by: Amit Kumar Paliwal, et al.
Published: (2019-10-01)

Subcutaneous emphysema as a clinical finding in emphysematous pyelonephritis
by: Vinicius Daher Alvares Delfino, et al.

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
by: Min-Wu Chao, et al.
Published: (2019-05-01)

Discovery of indole-3-butyric acid derivatives as potent histone deacetylase inhibitors
by: Yiming Chen, et al.
Published: (2021-01-01)

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors
by: Matthias G. J. Baud, et al.
Published: (2013-01-01)

Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors
by: Sheng Jiang, et al.
Published: (2011-06-01)

Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer
by: Ana Vuletić, et al.
Published: (2023-12-01)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
by: Masumeh Sanaei, et al.
Published: (2019-01-01)

Associations between Ozone and Emphysema: A Systematic Review and Meta-analysis
by: Manullang, Amja, et al.
Published: (2022)

Associations between Ozone and Emphysema: A Systematic Review and Meta-analysis
by: Amja Manullang, et al.
Published: (2022-05-01)

Resveratrol Prevents Skeletal Muscle Atrophy and Senescence via Regulation of Histone Deacetylase 2 in Cigarette Smoke-Induced Mice with Emphysema
by: Li C, et al.
Published: (2022-09-01)

Histone deacetylase 6 in cancer
by: Ting Li, et al.
Published: (2018-09-01)

1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors
by: Maurício T. Tavares, et al.
Published: (2023-11-01)

Identification of Combinations of Protein Kinase C Activators and Histone Deacetylase Inhibitors that Potently Reactivate Latent HIV
by: Francesca Curreli, et al.
Published: (2020-06-01)

Improved early development of porcine cloned embryos by treatment with quisinostat, a potent histone deacetylase inhibitor
by: Anukul TAWEECHAIPAISANKUL, et al.
Published: (2018-12-01)

A Novel Hydroxamic Acid-Based Curcumin Derivative as Potent Histone Deacetylase Inhibitor for the Treatment of Glioblastoma
by: Hao Wang, et al.
Published: (2021-11-01)

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
by: Anahid Ehteda, et al.
Published: (2021-04-01)

Synthesis and Biological Evaluation of Novel Thiazolyl-Coumarin Derivatives as Potent Histone Deacetylase Inhibitors with Antifibrotic Activity
by: Viviana Pardo-Jiménez, et al.
Published: (2019-02-01)

Role of histone deacetylases and their inhibitors in neurological diseases
by: Li-Ying Zhang, et al.
Published: (2024-10-01)

Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus
by: Wang Weijia, et al.
Published: (2011-03-01)

Histone acetylation-mediated regulation of the Hippo pathway.
by: Dipanjan Basu, et al.
Published: (2013-01-01)

Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
by: Yang Hai, et al.
Published: (2017-05-01)

Antidepressant Actions of Histone Deacetylase Inhibitors
by: Haggarty, Stephen J., et al.
Published: (2010)

Acetylation and Histone Deacetylase Inhibitors in Cancer
by: Madeleine S. Q. Kortenhorst, et al.
Published: (2006-01-01)

Targeting histone deacetylase in cardiac diseases
by: Jiao Lu, et al.
Published: (2024-06-01)

Histone deacetylase inhibitors in multiple myeloma
by: Sarah Deleu, et al.
Published: (2009-06-01)

Histone deacetylase-2 and airway disease
by: Peter J. Barnes
Published: (2009-10-01)

Histone Deacetylases in the Pathogenesis of Diabetic Cardiomyopathy
by: Xiangyu Ke, et al.
Published: (2021-07-01)

Histone deacetylases and their inhibition in Candida species
by: Cecile Garnaud, et al.
Published: (2016-08-01)

Clinical Toxicities of Histone Deacetylase Inhibitors
by: Richard L. Piekarz, et al.
Published: (2010-08-01)

Medicinal chemistry of histone deacetylase inhibitors
by: Ružić Dušan, et al.
Published: (2021-01-01)