Gut Microbiota Modulation of Moderate Undernutrition in Infants through Gummy Lactobacillus plantarum Dad-13 Consumption: A Randomized Double-Blind Controlled Trial
Undernutrition is associated with gut microbiota unbalance, and probiotics are believed to restore it and improve gut integrity. A randomized double-blind controlled trial was conducted to evaluate the efficacy of gummy L. plantarum Dad-13 (108−9 CFU/3 g) to prevent the progression of severe undernu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI
2022
|
| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/279034/1/Gut-Microbiota-Modulation-of-Moderate-Undernutrition-in-Infants-through-Gummy-Lactobacillus-plantarum-Dad13-Consumption-A-Randomized-DoubleBlind-Controlled-TrialNutrients.pdf |
| _version_ | 1797037408287457280 |
|---|---|
| author | Kamil, Rafli Zulfa Murdiati, Agnes Juffrie, Mohammad Rahayu, Endang Sutriswati |
| author_facet | Kamil, Rafli Zulfa Murdiati, Agnes Juffrie, Mohammad Rahayu, Endang Sutriswati |
| author_sort | Kamil, Rafli Zulfa |
| collection | UGM |
| description | Undernutrition is associated with gut microbiota unbalance, and probiotics are believed to restore it and improve gut integrity. A randomized double-blind controlled trial was conducted to evaluate the efficacy of gummy L. plantarum Dad-13 (108−9 CFU/3 g) to prevent the progression of severe undernutrition. Two groups of moderate undernutrition infants were involved in this study, namely the placebo (n = 15) and probiotics (n = 15) groups, and were required to consume the product for 50 days. 16S rRNA sequencing and qPCR were used for gut microbiota analysis, and gas chromatography was used to analyze Short-Chain Fatty Acid (SCFA). The daily food intake of both groups was recorded using food records. Our results revealed that the probiotic group had better improvements regarding the anthropometry and nutritional status. In addition, L. plantarum Dad-13 modulated the butyric acid-producing bacteria to increase and inhibit the growth of Enterobacteriaceae. This gut modulation was associated with the increment in SCFA, especially total SCFA, propionic, and butyric acid. The number of L. plantarum was increased after the probiotic intervention. However, L. plantarum Dad-13 was not able to change the alpha and beta diversity. Therefore, L. plantarum Dad-13 has been proven to promote the growth of beneficial bacteria. |
| first_indexed | 2024-03-14T00:02:51Z |
| format | Article |
| id | oai:generic.eprints.org:279034 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:02:51Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2790342023-10-30T05:25:51Z https://repository.ugm.ac.id/279034/ Gut Microbiota Modulation of Moderate Undernutrition in Infants through Gummy Lactobacillus plantarum Dad-13 Consumption: A Randomized Double-Blind Controlled Trial Kamil, Rafli Zulfa Murdiati, Agnes Juffrie, Mohammad Rahayu, Endang Sutriswati Food technology Undernutrition is associated with gut microbiota unbalance, and probiotics are believed to restore it and improve gut integrity. A randomized double-blind controlled trial was conducted to evaluate the efficacy of gummy L. plantarum Dad-13 (108−9 CFU/3 g) to prevent the progression of severe undernutrition. Two groups of moderate undernutrition infants were involved in this study, namely the placebo (n = 15) and probiotics (n = 15) groups, and were required to consume the product for 50 days. 16S rRNA sequencing and qPCR were used for gut microbiota analysis, and gas chromatography was used to analyze Short-Chain Fatty Acid (SCFA). The daily food intake of both groups was recorded using food records. Our results revealed that the probiotic group had better improvements regarding the anthropometry and nutritional status. In addition, L. plantarum Dad-13 modulated the butyric acid-producing bacteria to increase and inhibit the growth of Enterobacteriaceae. This gut modulation was associated with the increment in SCFA, especially total SCFA, propionic, and butyric acid. The number of L. plantarum was increased after the probiotic intervention. However, L. plantarum Dad-13 was not able to change the alpha and beta diversity. Therefore, L. plantarum Dad-13 has been proven to promote the growth of beneficial bacteria. MDPI 2022-03-01 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/279034/1/Gut-Microbiota-Modulation-of-Moderate-Undernutrition-in-Infants-through-Gummy-Lactobacillus-plantarum-Dad13-Consumption-A-Randomized-DoubleBlind-Controlled-TrialNutrients.pdf Kamil, Rafli Zulfa and Murdiati, Agnes and Juffrie, Mohammad and Rahayu, Endang Sutriswati (2022) Gut Microbiota Modulation of Moderate Undernutrition in Infants through Gummy Lactobacillus plantarum Dad-13 Consumption: A Randomized Double-Blind Controlled Trial. Nutrients, 14 (5). pp. 1-19. ISSN 20726643 https://www.mdpi.com/2072-6643/14/5/1049 https://doi.org/10.3390/nu14051049 |
| spellingShingle | Food technology Kamil, Rafli Zulfa Murdiati, Agnes Juffrie, Mohammad Rahayu, Endang Sutriswati Gut Microbiota Modulation of Moderate Undernutrition in Infants through Gummy Lactobacillus plantarum Dad-13 Consumption: A Randomized Double-Blind Controlled Trial |
| title | Gut Microbiota Modulation of Moderate Undernutrition in
Infants through Gummy Lactobacillus plantarum Dad-13
Consumption: A Randomized Double-Blind Controlled Trial |
| title_full | Gut Microbiota Modulation of Moderate Undernutrition in
Infants through Gummy Lactobacillus plantarum Dad-13
Consumption: A Randomized Double-Blind Controlled Trial |
| title_fullStr | Gut Microbiota Modulation of Moderate Undernutrition in
Infants through Gummy Lactobacillus plantarum Dad-13
Consumption: A Randomized Double-Blind Controlled Trial |
| title_full_unstemmed | Gut Microbiota Modulation of Moderate Undernutrition in
Infants through Gummy Lactobacillus plantarum Dad-13
Consumption: A Randomized Double-Blind Controlled Trial |
| title_short | Gut Microbiota Modulation of Moderate Undernutrition in
Infants through Gummy Lactobacillus plantarum Dad-13
Consumption: A Randomized Double-Blind Controlled Trial |
| title_sort | gut microbiota modulation of moderate undernutrition in infants through gummy lactobacillus plantarum dad 13 consumption a randomized double blind controlled trial |
| topic | Food technology |
| url | https://repository.ugm.ac.id/279034/1/Gut-Microbiota-Modulation-of-Moderate-Undernutrition-in-Infants-through-Gummy-Lactobacillus-plantarum-Dad13-Consumption-A-Randomized-DoubleBlind-Controlled-TrialNutrients.pdf |
| work_keys_str_mv | AT kamilraflizulfa gutmicrobiotamodulationofmoderateundernutritionininfantsthroughgummylactobacillusplantarumdad13consumptionarandomizeddoubleblindcontrolledtrial AT murdiatiagnes gutmicrobiotamodulationofmoderateundernutritionininfantsthroughgummylactobacillusplantarumdad13consumptionarandomizeddoubleblindcontrolledtrial AT juffriemohammad gutmicrobiotamodulationofmoderateundernutritionininfantsthroughgummylactobacillusplantarumdad13consumptionarandomizeddoubleblindcontrolledtrial AT rahayuendangsutriswati gutmicrobiotamodulationofmoderateundernutritionininfantsthroughgummylactobacillusplantarumdad13consumptionarandomizeddoubleblindcontrolledtrial |