Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article
The intervertebral disc (IVD) is an important structure in the human body because it functions as a weight-bearing. This structure undergoes a process of degeneration like the rest of the body and this process is known as intervertebral disc degeneration (IDD) which is the most common cause of low b...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2022
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| Online Access: | https://repository.ugm.ac.id/279147/1/Rhatomy-2_KKMK.pdf |
| _version_ | 1797037429676310528 |
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| author | Romaniyanto, FNU Mahyudin, Ferdiansyah Prakoeswa, Cita Rosita Sigit Notobroto, Hari Basuki Tinduh, Damayanti Ausrin, Ryan Rantam, Fedik Abdul Suroto, Heri Utomo, Dwikora Novembri Rhatomy, Sholahuddin |
| author_facet | Romaniyanto, FNU Mahyudin, Ferdiansyah Prakoeswa, Cita Rosita Sigit Notobroto, Hari Basuki Tinduh, Damayanti Ausrin, Ryan Rantam, Fedik Abdul Suroto, Heri Utomo, Dwikora Novembri Rhatomy, Sholahuddin |
| author_sort | Romaniyanto, FNU |
| collection | UGM |
| description | The intervertebral disc (IVD) is an important structure in the human body because it functions as a weight-bearing. This structure undergoes a process of degeneration like the rest of the body and this process is known as intervertebral disc degeneration (IDD) which is the most common cause of low back pain (LBP). The current common management, either conservative or surgical, is pain-relieving and has not been able to restore degenerated disc optimally. Changes in the IVD microenvironment in IDD conditions make it difficult for the regeneration process to occur. Research to reverse the degeneration process continues to develop, one of them is the use of adipose-derived stem cells (ASCs). ASCs is superior due to the ability to differentiate into several other cells such as adipocytes, chondrocytes, and osteoblasts, it also has ability to act as immunomodulators by stimulating the migration of immune cells to damaged tissues. ASCs becomes a good choice because it is easy to obtain, low donor site morbidity, high proliferation rate, and excellent differentiation abilities. Research on the optimal preparation process for ASCs and their application to various disorders continues to advanced. This study aims to review the potential use of ASCs for regeneration of intervertebral disc degeneration. |
| first_indexed | 2024-03-14T00:03:11Z |
| format | Article |
| id | oai:generic.eprints.org:279147 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:03:11Z |
| publishDate | 2022 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2791472023-11-03T00:22:43Z https://repository.ugm.ac.id/279147/ Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article Romaniyanto, FNU Mahyudin, Ferdiansyah Prakoeswa, Cita Rosita Sigit Notobroto, Hari Basuki Tinduh, Damayanti Ausrin, Ryan Rantam, Fedik Abdul Suroto, Heri Utomo, Dwikora Novembri Rhatomy, Sholahuddin Clinical Sciences The intervertebral disc (IVD) is an important structure in the human body because it functions as a weight-bearing. This structure undergoes a process of degeneration like the rest of the body and this process is known as intervertebral disc degeneration (IDD) which is the most common cause of low back pain (LBP). The current common management, either conservative or surgical, is pain-relieving and has not been able to restore degenerated disc optimally. Changes in the IVD microenvironment in IDD conditions make it difficult for the regeneration process to occur. Research to reverse the degeneration process continues to develop, one of them is the use of adipose-derived stem cells (ASCs). ASCs is superior due to the ability to differentiate into several other cells such as adipocytes, chondrocytes, and osteoblasts, it also has ability to act as immunomodulators by stimulating the migration of immune cells to damaged tissues. ASCs becomes a good choice because it is easy to obtain, low donor site morbidity, high proliferation rate, and excellent differentiation abilities. Research on the optimal preparation process for ASCs and their application to various disorders continues to advanced. This study aims to review the potential use of ASCs for regeneration of intervertebral disc degeneration. Taylor & Francis 2022-11-04 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/279147/1/Rhatomy-2_KKMK.pdf Romaniyanto, FNU and Mahyudin, Ferdiansyah and Prakoeswa, Cita Rosita Sigit and Notobroto, Hari Basuki and Tinduh, Damayanti and Ausrin, Ryan and Rantam, Fedik Abdul and Suroto, Heri and Utomo, Dwikora Novembri and Rhatomy, Sholahuddin (2022) Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article. Stem Cells and Cloning: Advances and Applications, 2022 (15). pp. 67-76. ISSN 1178-6957 https://www.dovepress.com/adipose-derived-stem-cells-ascs-for-regeneration-of-intervertebral-dis-peer-reviewed-fulltext-article-SCCAA https://doi.org/10.2147/SCCAA.S379714 |
| spellingShingle | Clinical Sciences Romaniyanto, FNU Mahyudin, Ferdiansyah Prakoeswa, Cita Rosita Sigit Notobroto, Hari Basuki Tinduh, Damayanti Ausrin, Ryan Rantam, Fedik Abdul Suroto, Heri Utomo, Dwikora Novembri Rhatomy, Sholahuddin Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article |
| title | Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article |
| title_full | Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article |
| title_fullStr | Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article |
| title_full_unstemmed | Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article |
| title_short | Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article |
| title_sort | adipose derived stem cells ascs for regeneration of intervertebral disc degeneration review article |
| topic | Clinical Sciences |
| url | https://repository.ugm.ac.id/279147/1/Rhatomy-2_KKMK.pdf |
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