DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION
ABSTRACT X-ray diffraction (XRD) is a powerful technique for the study of polymorphism and polymorphic phase transformations.Monitoring of phase transformationdirectly has been ve/}' limited to-date. TheXRD system used in this study was used to determine the rate of transformationof pure glutam...
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| 格式: | 文件 |
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[Yogyakarta] : Universitas Gadjah Mada
2008
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| _version_ | 1826033126145523712 |
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| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | ABSTRACT
X-ray diffraction (XRD) is a powerful technique for the study of polymorphism and polymorphic phase
transformations.Monitoring of phase transformationdirectly has been ve/}' limited to-date. TheXRD system used in
this study was used to determine the rate of transformationof pure glutamic acid a form to 13form in a solution
mediatedphase. On eve/}' run starting from the pure a form, the transformationprocess was monitored continuously
at fixed temperature, and separate experiments were performed as a function of temperature. The operating
temperaturewas varied from 36 to 57 °C with 10%w/w solid concentration.Data were taken eve/}' 200 secondsuntil
the transformationwas completed. Thispaper is concemed with a study of the transformationof the alpha (a) form
of L-glutamic acid (L-GA) to the beta (13)form in order to determine the kinetic reaction. The rate constant (k),
activation energy (Ea) and pre-exponential factor (A) were obtained. Sensitivity tests were also carried out to
examineminimum detection limit whenboth a and 13present in the mixture. In addition, effect of particle size on XRD
pattems was also determined. The results show that XRD gives useful information to observe polymorphism for
pharmaceuticalmdust/}'.
Keywords: XRD, polymorphism, glutamic acid, reaction kinetics |
| first_indexed | 2024-03-05T23:11:45Z |
| format | Article |
| id | oai:generic.eprints.org:27923 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-05T23:11:45Z |
| publishDate | 2008 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:279232014-06-18T00:24:49Z https://repository.ugm.ac.id/27923/ DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION Perpustakaan UGM, i-lib Jurnal i-lib UGM ABSTRACT X-ray diffraction (XRD) is a powerful technique for the study of polymorphism and polymorphic phase transformations.Monitoring of phase transformationdirectly has been ve/}' limited to-date. TheXRD system used in this study was used to determine the rate of transformationof pure glutamic acid a form to 13form in a solution mediatedphase. On eve/}' run starting from the pure a form, the transformationprocess was monitored continuously at fixed temperature, and separate experiments were performed as a function of temperature. The operating temperaturewas varied from 36 to 57 °C with 10%w/w solid concentration.Data were taken eve/}' 200 secondsuntil the transformationwas completed. Thispaper is concemed with a study of the transformationof the alpha (a) form of L-glutamic acid (L-GA) to the beta (13)form in order to determine the kinetic reaction. The rate constant (k), activation energy (Ea) and pre-exponential factor (A) were obtained. Sensitivity tests were also carried out to examineminimum detection limit whenboth a and 13present in the mixture. In addition, effect of particle size on XRD pattems was also determined. The results show that XRD gives useful information to observe polymorphism for pharmaceuticalmdust/}'. Keywords: XRD, polymorphism, glutamic acid, reaction kinetics [Yogyakarta] : Universitas Gadjah Mada 2008 Article NonPeerReviewed Perpustakaan UGM, i-lib (2008) DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=10986 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION |
| title | DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION |
| title_full | DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION |
| title_fullStr | DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION |
| title_full_unstemmed | DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION |
| title_short | DETERMINATIONOF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION |
| title_sort | determinationof reaction kinetics using online x ray diffraction |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib determinationofreactionkineticsusingonlinexraydiffraction |