BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE
ABSTRACT Isolation and elucidation of benzophenone glucoside from ethyl acetate extract of Phaleria macrocarpa bark and its inhibitory activity test against leukemia L 1210 cel/line have been done. The Phalaria macrocarpa bark were maceratedusing n-hexane,ethyl acetate, and ethanol,respectively.The...
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| Format: | Article |
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[Yogyakarta] : Universitas Gadjah Mada
2008
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| _version_ | 1797019811154231296 |
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| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | ABSTRACT
Isolation and elucidation of benzophenone glucoside from ethyl acetate extract of Phaleria macrocarpa bark
and its inhibitory activity test against leukemia L 1210 cel/line have been done. The Phalaria macrocarpa bark were
maceratedusing n-hexane,ethyl acetate, and ethanol,respectively.The ethyl acetate extract was then
chromatographedon silica gel column and gradientlyeluted by n-hexane - ethyl acetate - ethanol with the
composition from 20:1:0 until 0:0:1, gave eight fractions. Separation of fraction 6 using semipreparative HPLC on
reverse phase column (Capeel/ Pak C-18 SG120, 15 mm I.D. x 250 mm) using methanol- water (40:60, 5 mUmin)
gave a brown powder, with the melting point of 182.3 "C. Spectroscopic analysis and comparison of its physicochemical
data, this compound was clarified as 2,4'-dihydroxy-4-methoxy~nzophenone-6-0-P.D-glucopyranoside
(3). Inhibitory activity of its compound against leukemia L1210 cel/line showed that this compound exhibited
inhibitory activity with IC50 was 5.1pg/mL. |
| first_indexed | 2024-03-13T19:05:26Z |
| format | Article |
| id | oai:generic.eprints.org:27984 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T19:05:26Z |
| publishDate | 2008 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:279842014-06-18T00:24:47Z https://repository.ugm.ac.id/27984/ BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE Perpustakaan UGM, i-lib Jurnal i-lib UGM ABSTRACT Isolation and elucidation of benzophenone glucoside from ethyl acetate extract of Phaleria macrocarpa bark and its inhibitory activity test against leukemia L 1210 cel/line have been done. The Phalaria macrocarpa bark were maceratedusing n-hexane,ethyl acetate, and ethanol,respectively.The ethyl acetate extract was then chromatographedon silica gel column and gradientlyeluted by n-hexane - ethyl acetate - ethanol with the composition from 20:1:0 until 0:0:1, gave eight fractions. Separation of fraction 6 using semipreparative HPLC on reverse phase column (Capeel/ Pak C-18 SG120, 15 mm I.D. x 250 mm) using methanol- water (40:60, 5 mUmin) gave a brown powder, with the melting point of 182.3 "C. Spectroscopic analysis and comparison of its physicochemical data, this compound was clarified as 2,4'-dihydroxy-4-methoxy~nzophenone-6-0-P.D-glucopyranoside (3). Inhibitory activity of its compound against leukemia L1210 cel/line showed that this compound exhibited inhibitory activity with IC50 was 5.1pg/mL. [Yogyakarta] : Universitas Gadjah Mada 2008 Article NonPeerReviewed Perpustakaan UGM, i-lib (2008) BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=11047 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE |
| title | BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE |
| title_full | BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE |
| title_fullStr | BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE |
| title_full_unstemmed | BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE |
| title_short | BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Pha/eria macrocarpa (Scheff.) Boerl.) AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE |
| title_sort | benzophenone glucoside isolated from the ethyl acetate extract of the bark of mahkota dewa pha eria macrocarpa scheff boerl and its inhibitory activity on leukemia l1210 cell line |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib benzophenoneglucosideisolatedfromtheethylacetateextractofthebarkofmahkotadewaphaeriamacrocarpascheffboerlanditsinhibitoryactivityonleukemial1210cellline |