DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID
ABSTRACT The effects of dietary adenine in fatty liver induced by orotic acid (OA) were studied. Rats were paired-fed 1% OA-supplemented diets with/or without 0.25% adenine or a diet without OA for 10 days. Serum lipid profiles were measured using enzyme assay kits. Lipids of liver tissues were extr...
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| Format: | Article |
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[Yogyakarta] : Universitas Gadjah Mada
2010
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| _version_ | 1826033161862119424 |
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| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | ABSTRACT
The effects of dietary adenine in fatty liver induced by orotic acid (OA) were studied. Rats were paired-fed 1%
OA-supplemented diets with/or without 0.25% adenine or a diet without OA for 10 days. Serum lipid profiles were measured using enzyme assay kits. Lipids of liver tissues were extracted and liver lipid contents were determined.A peach of liver was prepared to determine the activities of fatty acid synthase (FAS) and fatty acid {3-oxidation.The results showed that liver TG content of OA-fed rats increased markedly in comparison to basal group. However, the addition of adenine to the diet reversed promotion of liver TG content to basal level. It was also found that FAS activities decreased. Furthermore, these diets reversed the inhibition of fatty acid {3-oxidationto basal level and induced the serum lipid levels secretion. Therefore, the alleviation of fatty liver in OA-treated rats given dietary adenine is associated with the inhibition of FAS activities accompanied with the promotion of mitochondrial fatty acid {3-oxidationand the promotion of serum lipid secretion from the hepatic tissue into the bloodstream.
Keywords: adenine, orotic acid, serum lipid, triglyceride, fatty liver, hepatic steatosis |
| first_indexed | 2024-03-13T19:05:48Z |
| format | Article |
| id | oai:generic.eprints.org:28107 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T19:05:48Z |
| publishDate | 2010 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:281072014-06-18T00:23:53Z https://repository.ugm.ac.id/28107/ DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID Perpustakaan UGM, i-lib Jurnal i-lib UGM ABSTRACT The effects of dietary adenine in fatty liver induced by orotic acid (OA) were studied. Rats were paired-fed 1% OA-supplemented diets with/or without 0.25% adenine or a diet without OA for 10 days. Serum lipid profiles were measured using enzyme assay kits. Lipids of liver tissues were extracted and liver lipid contents were determined.A peach of liver was prepared to determine the activities of fatty acid synthase (FAS) and fatty acid {3-oxidation.The results showed that liver TG content of OA-fed rats increased markedly in comparison to basal group. However, the addition of adenine to the diet reversed promotion of liver TG content to basal level. It was also found that FAS activities decreased. Furthermore, these diets reversed the inhibition of fatty acid {3-oxidationto basal level and induced the serum lipid levels secretion. Therefore, the alleviation of fatty liver in OA-treated rats given dietary adenine is associated with the inhibition of FAS activities accompanied with the promotion of mitochondrial fatty acid {3-oxidationand the promotion of serum lipid secretion from the hepatic tissue into the bloodstream. Keywords: adenine, orotic acid, serum lipid, triglyceride, fatty liver, hepatic steatosis [Yogyakarta] : Universitas Gadjah Mada 2010 Article NonPeerReviewed Perpustakaan UGM, i-lib (2010) DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=11170 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID |
| title | DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID |
| title_full | DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID |
| title_fullStr | DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID |
| title_full_unstemmed | DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID |
| title_short | DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCEDBY OROTICACID |
| title_sort | dietary adenine alleviates fatty liver inducedby oroticacid |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib dietaryadeninealleviatesfattyliverinducedbyoroticacid |