Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines
ABSTRACT Mirabilis jalapa L. contains basic (MJ30) and acidic (MJC) Ribosome-inactivating proteins (RIPsl. Further purification of MJC has been found two RIPs, MJCO.3and MJCo... This study is aimed to prove the cytotoxic selectivity of MJCo.3andMJCo..against many cancer cell-lines and normal cell li...
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| Format: | Article |
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[Yogyakarta] : Universitas Gadjah Mada
2010
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| _version_ | 1826033164603097088 |
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| author | Perpustakaan UGM, i-lib |
| author_facet | Perpustakaan UGM, i-lib |
| author_sort | Perpustakaan UGM, i-lib |
| collection | UGM |
| description | ABSTRACT
Mirabilis jalapa L. contains basic (MJ30) and acidic (MJC) Ribosome-inactivating proteins (RIPsl. Further
purification of MJC has been found two RIPs, MJCO.3and MJCo... This study is aimed to prove the cytotoxic selectivity of MJCo.3andMJCo..against many cancer cell-lines and normal cell line. The two RIPs,MJCo.3andMJCo.. were tested their cytotoxic effect on 8 human cancer cell lines and normal cell using MTT assay compared with MJC protein. The highest cytotoxic activities of MJCO.3and MJCo.. were against EVSA-T followed by T47D, HeLa, WiDR, SiHa, Raji, NS1, and MCF7, with the IC.oof 59.3,102.4,162.9,190.5,249.5, and 304.5I!g/mL,
respectively for MJCO.3and 32.8, 75.5, 86.0,108.3,346.7, and 220.06I!g/mL, respectively for MJCo... Based on these IC.o values, MJCO.3and MJCo.. were specific to EVSA-T and T47D, whereas they were not selective against Raji and SiHa (SI< 10.0). It can be concluded that he acidic RIPs isolated from M. jalapa L. leaves was potential to be developed as anticancer agents for breast cancer.
Key words: acidic RIPs - M. jalapa L.- cytotoxic selectivity - cancer eel/lines. |
| first_indexed | 2024-03-13T19:05:51Z |
| format | Article |
| id | oai:generic.eprints.org:28121 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T19:05:51Z |
| publishDate | 2010 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:281212014-06-18T00:23:52Z https://repository.ugm.ac.id/28121/ Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines Perpustakaan UGM, i-lib Jurnal i-lib UGM ABSTRACT Mirabilis jalapa L. contains basic (MJ30) and acidic (MJC) Ribosome-inactivating proteins (RIPsl. Further purification of MJC has been found two RIPs, MJCO.3and MJCo... This study is aimed to prove the cytotoxic selectivity of MJCo.3andMJCo..against many cancer cell-lines and normal cell line. The two RIPs,MJCo.3andMJCo.. were tested their cytotoxic effect on 8 human cancer cell lines and normal cell using MTT assay compared with MJC protein. The highest cytotoxic activities of MJCO.3and MJCo.. were against EVSA-T followed by T47D, HeLa, WiDR, SiHa, Raji, NS1, and MCF7, with the IC.oof 59.3,102.4,162.9,190.5,249.5, and 304.5I!g/mL, respectively for MJCO.3and 32.8, 75.5, 86.0,108.3,346.7, and 220.06I!g/mL, respectively for MJCo... Based on these IC.o values, MJCO.3and MJCo.. were specific to EVSA-T and T47D, whereas they were not selective against Raji and SiHa (SI< 10.0). It can be concluded that he acidic RIPs isolated from M. jalapa L. leaves was potential to be developed as anticancer agents for breast cancer. Key words: acidic RIPs - M. jalapa L.- cytotoxic selectivity - cancer eel/lines. [Yogyakarta] : Universitas Gadjah Mada 2010 Article NonPeerReviewed Perpustakaan UGM, i-lib (2010) Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=11184 |
| spellingShingle | Jurnal i-lib UGM Perpustakaan UGM, i-lib Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines |
| title | Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines |
| title_full | Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines |
| title_fullStr | Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines |
| title_full_unstemmed | Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines |
| title_short | Cytotoxic selectivity of MJCO.3 and MJCo.s, acidic ribosome-inactivating proteins isolated from Mirabilis jalapa L. leaves against various cancer cell-lines |
| title_sort | cytotoxic selectivity of mjco 3 and mjco s acidic ribosome inactivating proteins isolated from mirabilis jalapa l leaves against various cancer cell lines |
| topic | Jurnal i-lib UGM |
| work_keys_str_mv | AT perpustakaanugmilib cytotoxicselectivityofmjco3andmjcosacidicribosomeinactivatingproteinsisolatedfrommirabilisjalapalleavesagainstvariouscancercelllines |