Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation
Alginate is one of the natural biopolymers that is widely used for drug formulations, combination of alginate with other polymers, such as gum acacia, pectin, and carrageenan can increase mechanical strength, therefore, can reduce leakage of the encapsulated active pharmaceutical ingredient from the...
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| Format: | Article |
| Language: | English |
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University of Baghdad - College of Pharmacy
2022
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| Online Access: | https://repository.ugm.ac.id/281833/1/Characterization%20of%20Alginate%20with%20Natural%20Polymers%20Combination%20for%20Drug%20Encapsulation.pdf |
| _version_ | 1826050441707782144 |
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| author | Annisa, Viviane Sulaiman, Teuku Nanda Saifullah Nugroho, Akhmad Kharis Nugroho, Agung Endro |
| author_facet | Annisa, Viviane Sulaiman, Teuku Nanda Saifullah Nugroho, Akhmad Kharis Nugroho, Agung Endro |
| author_sort | Annisa, Viviane |
| collection | UGM |
| description | Alginate is one of the natural biopolymers that is widely used for drug formulations, combination of alginate with other polymers, such as gum acacia, pectin, and carrageenan can increase mechanical strength, therefore, can reduce leakage of the encapsulated active pharmaceutical ingredient from the polymer matrix. Interaction of alginate and these polymers can occur via intermolecular hydrogen bonds causing synergism, which is determined from the viscosity of polymer mixture. Alginate was combined with gum acacia/pectin/carrageenan in different blending ratios (100:0, 75:25, 50:50, 25:75, and 0:100) with and without addition of CaCl2. The synergism effect is obtained from the design of experimental (DoE), and calculation the percentage value of viscosity deviation viscosity synergism index, then the strength of gel was analyzed. The interaction between two polymers was observed using FTIR spectroscopy. In distilled water, the synergistic effect was found in the combination of alginate-carrageenan at ratios 25:75 and 50:50. Otherwise, in CaCl2 solution, synergistic effect appears in alginate-gum acacia (75:25), alginate-pectin (50:50 and 75:25), and alginate-carrageenan (50:50 and 75:25). The synergistic effect and strength of gel polymers increased, with the addition of CaCl2. |
| first_indexed | 2024-03-14T00:04:02Z |
| format | Article |
| id | oai:generic.eprints.org:281833 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:04:02Z |
| publishDate | 2022 |
| publisher | University of Baghdad - College of Pharmacy |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2818332023-11-14T06:08:16Z https://repository.ugm.ac.id/281833/ Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation Annisa, Viviane Sulaiman, Teuku Nanda Saifullah Nugroho, Akhmad Kharis Nugroho, Agung Endro Pharmaceutical Sciences Pharmacology and Pharmaceutical Sciences Pharmaceutical Sciences Alginate is one of the natural biopolymers that is widely used for drug formulations, combination of alginate with other polymers, such as gum acacia, pectin, and carrageenan can increase mechanical strength, therefore, can reduce leakage of the encapsulated active pharmaceutical ingredient from the polymer matrix. Interaction of alginate and these polymers can occur via intermolecular hydrogen bonds causing synergism, which is determined from the viscosity of polymer mixture. Alginate was combined with gum acacia/pectin/carrageenan in different blending ratios (100:0, 75:25, 50:50, 25:75, and 0:100) with and without addition of CaCl2. The synergism effect is obtained from the design of experimental (DoE), and calculation the percentage value of viscosity deviation viscosity synergism index, then the strength of gel was analyzed. The interaction between two polymers was observed using FTIR spectroscopy. In distilled water, the synergistic effect was found in the combination of alginate-carrageenan at ratios 25:75 and 50:50. Otherwise, in CaCl2 solution, synergistic effect appears in alginate-gum acacia (75:25), alginate-pectin (50:50 and 75:25), and alginate-carrageenan (50:50 and 75:25). The synergistic effect and strength of gel polymers increased, with the addition of CaCl2. University of Baghdad - College of Pharmacy 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/281833/1/Characterization%20of%20Alginate%20with%20Natural%20Polymers%20Combination%20for%20Drug%20Encapsulation.pdf Annisa, Viviane and Sulaiman, Teuku Nanda Saifullah and Nugroho, Akhmad Kharis and Nugroho, Agung Endro (2022) Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation. Iraqi Journal of Pharmaceutical Sciences, 31 (2). pp. 150-159. ISSN 16833597 https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1572 https://doi.org/10.31351/vol31iss2pp150-159 |
| spellingShingle | Pharmaceutical Sciences Pharmacology and Pharmaceutical Sciences Pharmaceutical Sciences Annisa, Viviane Sulaiman, Teuku Nanda Saifullah Nugroho, Akhmad Kharis Nugroho, Agung Endro Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation |
| title | Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation |
| title_full | Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation |
| title_fullStr | Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation |
| title_full_unstemmed | Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation |
| title_short | Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation |
| title_sort | characterization of alginate with natural polymers combination for drug encapsulation |
| topic | Pharmaceutical Sciences Pharmacology and Pharmaceutical Sciences Pharmaceutical Sciences |
| url | https://repository.ugm.ac.id/281833/1/Characterization%20of%20Alginate%20with%20Natural%20Polymers%20Combination%20for%20Drug%20Encapsulation.pdf |
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