Bioaccessibility and antioxidant activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein
β-carotene (βC) is an essential nutrient for health. It is a potent antioxidant, anti-cancer, and anti-inflammatory substance. However, βC has high hydrophobicity property, indicating a low absorption level in the digestive tract. The bioavailability of βC is reasonably low. Lipid-based delivery sy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2022
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| Online Access: | https://repository.ugm.ac.id/282003/1/Raharjo_TP.pdf |
| _version_ | 1826050467414671360 |
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| author | Rohmah, Miftakhur Rahmadi, Anton Raharjo, Sri |
| author_facet | Rohmah, Miftakhur Rahmadi, Anton Raharjo, Sri |
| author_sort | Rohmah, Miftakhur |
| collection | UGM |
| description | β-carotene (βC) is an essential nutrient for health. It is a potent antioxidant, anti-cancer, and anti-inflammatory
substance. However, βC has high hydrophobicity property, indicating a low absorption level in the digestive tract. The bioavailability of βC is reasonably low. Lipid-based delivery systems such as nanostructured lipid carriers (NLC) potentially can help to overcome this problem. This research evaluated the bioaccessibility of the nanostructured mixture of palm stearin (PS) and palm olein (PO) and the antioxidant activity of βC in the structure. β-carotene bioaccessibility was studied by measuring the micellization during in vitro digestion. Anti-oxidants activity was measured by 2.20 -azino-bis (3-ethylbenzothiazoline- 6-sulphonic acid) (ABTS) and 2, 2 –diphenyl -1- picrylhydrazyl (DPPH) reduction methods. In vitro gastrointestinal digestion model indicated that nanostructured lipid carrier enhanced bioaccessibility and antioxidants activity of βC. This suggests that the
formulated NLC system can be used effectively to deliver lipophilic bioactive such as βC in beverage products. |
| first_indexed | 2024-03-14T00:04:26Z |
| format | Article |
| id | oai:generic.eprints.org:282003 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:04:26Z |
| publishDate | 2022 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2820032023-11-16T00:52:28Z https://repository.ugm.ac.id/282003/ Bioaccessibility and antioxidant activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein Rohmah, Miftakhur Rahmadi, Anton Raharjo, Sri Food Sciences Food Engineering β-carotene (βC) is an essential nutrient for health. It is a potent antioxidant, anti-cancer, and anti-inflammatory substance. However, βC has high hydrophobicity property, indicating a low absorption level in the digestive tract. The bioavailability of βC is reasonably low. Lipid-based delivery systems such as nanostructured lipid carriers (NLC) potentially can help to overcome this problem. This research evaluated the bioaccessibility of the nanostructured mixture of palm stearin (PS) and palm olein (PO) and the antioxidant activity of βC in the structure. β-carotene bioaccessibility was studied by measuring the micellization during in vitro digestion. Anti-oxidants activity was measured by 2.20 -azino-bis (3-ethylbenzothiazoline- 6-sulphonic acid) (ABTS) and 2, 2 –diphenyl -1- picrylhydrazyl (DPPH) reduction methods. In vitro gastrointestinal digestion model indicated that nanostructured lipid carrier enhanced bioaccessibility and antioxidants activity of βC. This suggests that the formulated NLC system can be used effectively to deliver lipophilic bioactive such as βC in beverage products. Elsevier Ltd 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/282003/1/Raharjo_TP.pdf Rohmah, Miftakhur and Rahmadi, Anton and Raharjo, Sri (2022) Bioaccessibility and antioxidant activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein. Heliyon, 8 (2022). pp. 1-9. ISSN 2405-8440 http://www.cell.com/heliyon https://doi.org/10.1016/j.heliyon.2022.e08913 |
| spellingShingle | Food Sciences Food Engineering Rohmah, Miftakhur Rahmadi, Anton Raharjo, Sri Bioaccessibility and antioxidant activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein |
| title | Bioaccessibility and antioxidant activity of β-carotene loaded
nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein |
| title_full | Bioaccessibility and antioxidant activity of β-carotene loaded
nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein |
| title_fullStr | Bioaccessibility and antioxidant activity of β-carotene loaded
nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein |
| title_full_unstemmed | Bioaccessibility and antioxidant activity of β-carotene loaded
nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein |
| title_short | Bioaccessibility and antioxidant activity of β-carotene loaded
nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein |
| title_sort | bioaccessibility and antioxidant activity of β carotene loaded nanostructured lipid carrier nlc from binary mixtures of palm stearin and palm olein |
| topic | Food Sciences Food Engineering |
| url | https://repository.ugm.ac.id/282003/1/Raharjo_TP.pdf |
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