Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report
Background: Rubella is a common inherited infection resulting in congenital cataracts and a signifcant cause of permanent vision loss in developing countries. In 2016, Indonesia had the highest number of congenital rubella syndrome (CRS) cases globally. Here, we report the frst genotype of the rubel...
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Language: | English |
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BioMed Central Ltd
2022
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Online Access: | https://repository.ugm.ac.id/282297/1/12887_2022_Article_3775.pdf |
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author | Herini, Elisabeth Siti Triono, Agung Iskandar, Kristy Nuady, Albaaza Pujiastuti, Lucia Hetty Marcellus, Marcellus Nugrahanto, Andika Priamas Kamal, Musthofa Gunadi, Gunadi |
author_facet | Herini, Elisabeth Siti Triono, Agung Iskandar, Kristy Nuady, Albaaza Pujiastuti, Lucia Hetty Marcellus, Marcellus Nugrahanto, Andika Priamas Kamal, Musthofa Gunadi, Gunadi |
author_sort | Herini, Elisabeth Siti |
collection | UGM |
description | Background: Rubella is a common inherited infection resulting in congenital cataracts and a signifcant cause of permanent vision loss in developing countries. In 2016, Indonesia had the highest number of congenital rubella syndrome (CRS) cases globally. Here, we report the frst genotype of the rubella virus extracted from the eye lens from a child with congenital cataracts due to CRS.
Case presentation: A female neonate was delivered by an elective caesarean delivery with normal birth weight at term from a 24-year-old mother in the rural setting. The baby presented with bilateral congenital cataracts, smallmoderate secundum atrial septal defect, severe supravalvular pulmonary stenosis, and profound bilateral hearing loss. She also had microcephaly and splenomegaly. The patient’s serology showed persistent positive IgG for rubella virus at the age of four years and four months. Following extraction during cataract surgery, viral detection of the lenses identifed the presence of rubella. Phylogenetic analysis confrmed that the virus was grouped into genotype 1E.
Conclusions: Our study reports the frst phylogenetic analysis of the rubella virus extracted from the eye lens of a child with CRS in Indonesia. The detection of the rubella virus from eye lenses is remarkably promising. Our fndings also emphasize the importance of molecular epidemiology in tracking the origin of rubella infection toward achieving virus eradication. |
first_indexed | 2024-03-14T00:05:21Z |
format | Article |
id | oai:generic.eprints.org:282297 |
institution | Universiti Gadjah Mada |
language | English |
last_indexed | 2024-03-14T00:05:21Z |
publishDate | 2022 |
publisher | BioMed Central Ltd |
record_format | dspace |
spelling | oai:generic.eprints.org:2822972023-11-16T03:02:02Z https://repository.ugm.ac.id/282297/ Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report Herini, Elisabeth Siti Triono, Agung Iskandar, Kristy Nuady, Albaaza Pujiastuti, Lucia Hetty Marcellus, Marcellus Nugrahanto, Andika Priamas Kamal, Musthofa Gunadi, Gunadi Medical Virology Background: Rubella is a common inherited infection resulting in congenital cataracts and a signifcant cause of permanent vision loss in developing countries. In 2016, Indonesia had the highest number of congenital rubella syndrome (CRS) cases globally. Here, we report the frst genotype of the rubella virus extracted from the eye lens from a child with congenital cataracts due to CRS. Case presentation: A female neonate was delivered by an elective caesarean delivery with normal birth weight at term from a 24-year-old mother in the rural setting. The baby presented with bilateral congenital cataracts, smallmoderate secundum atrial septal defect, severe supravalvular pulmonary stenosis, and profound bilateral hearing loss. She also had microcephaly and splenomegaly. The patient’s serology showed persistent positive IgG for rubella virus at the age of four years and four months. Following extraction during cataract surgery, viral detection of the lenses identifed the presence of rubella. Phylogenetic analysis confrmed that the virus was grouped into genotype 1E. Conclusions: Our study reports the frst phylogenetic analysis of the rubella virus extracted from the eye lens of a child with CRS in Indonesia. The detection of the rubella virus from eye lenses is remarkably promising. Our fndings also emphasize the importance of molecular epidemiology in tracking the origin of rubella infection toward achieving virus eradication. BioMed Central Ltd 2022-12-13 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/282297/1/12887_2022_Article_3775.pdf Herini, Elisabeth Siti and Triono, Agung and Iskandar, Kristy and Nuady, Albaaza and Pujiastuti, Lucia Hetty and Marcellus, Marcellus and Nugrahanto, Andika Priamas and Kamal, Musthofa and Gunadi, Gunadi (2022) Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report. BMC Pediatrics, 22 (1). pp. 1-7. ISSN 14712431 https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03775-4 10.1186/s12887-022-03775-4 |
spellingShingle | Medical Virology Herini, Elisabeth Siti Triono, Agung Iskandar, Kristy Nuady, Albaaza Pujiastuti, Lucia Hetty Marcellus, Marcellus Nugrahanto, Andika Priamas Kamal, Musthofa Gunadi, Gunadi Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report |
title | Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report |
title_full | Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report |
title_fullStr | Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report |
title_full_unstemmed | Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report |
title_short | Phylogenetic Analysis of Congenital Rubella Virus from Indonesia: a case report |
title_sort | phylogenetic analysis of congenital rubella virus from indonesia a case report |
topic | Medical Virology |
url | https://repository.ugm.ac.id/282297/1/12887_2022_Article_3775.pdf |
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