The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform can...
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| Format: | Article |
| Language: | English |
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Elsevier
2022
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/282673/1/tran_khan%20bao.pdf |
| _version_ | 1826050534346326016 |
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| author | Tran, Khanh Bao Lang, Justin J. Compton, Kelly Xu, Rixing Acheson, Alistair R. Henrikson, Hannah Jacqueline Kocarnik, Jonathan M. Penberthy, Louise Aali, Amirali Abbas, Qamar Abbasi, Behzad Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abbastabar, Hedayat Abdelmasseh, Michael Abd-Elsalam, Sherief Abdelwahab, Ahmed Abdelwahab Abdoli, Gholamreza Abdulkadir, Hanan Abdulkadir Abedi, Aidin Abegaz, Kedir Hussein Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Absalan, Abdorrahim Abtew, Yonas Derso Abubaker Ali, Hiwa Abu-Gharbieh, Eman Achappa, Basavaprabhu |
| author_facet | Tran, Khanh Bao Lang, Justin J. Compton, Kelly Xu, Rixing Acheson, Alistair R. Henrikson, Hannah Jacqueline Kocarnik, Jonathan M. Penberthy, Louise Aali, Amirali Abbas, Qamar Abbasi, Behzad Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abbastabar, Hedayat Abdelmasseh, Michael Abd-Elsalam, Sherief Abdelwahab, Ahmed Abdelwahab Abdoli, Gholamreza Abdulkadir, Hanan Abdulkadir Abedi, Aidin Abegaz, Kedir Hussein Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Absalan, Abdorrahim Abtew, Yonas Derso Abubaker Ali, Hiwa Abu-Gharbieh, Eman Achappa, Basavaprabhu |
| author_sort | Tran, Khanh Bao |
| collection | UGM |
| description | Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally.
Methods: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented.
Findings: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). |
| first_indexed | 2024-03-14T00:05:30Z |
| format | Article |
| id | oai:generic.eprints.org:282673 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:05:30Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2826732023-11-16T06:24:13Z https://repository.ugm.ac.id/282673/ The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 Tran, Khanh Bao Lang, Justin J. Compton, Kelly Xu, Rixing Acheson, Alistair R. Henrikson, Hannah Jacqueline Kocarnik, Jonathan M. Penberthy, Louise Aali, Amirali Abbas, Qamar Abbasi, Behzad Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abbastabar, Hedayat Abdelmasseh, Michael Abd-Elsalam, Sherief Abdelwahab, Ahmed Abdelwahab Abdoli, Gholamreza Abdulkadir, Hanan Abdulkadir Abedi, Aidin Abegaz, Kedir Hussein Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Absalan, Abdorrahim Abtew, Yonas Derso Abubaker Ali, Hiwa Abu-Gharbieh, Eman Achappa, Basavaprabhu Cancer Diagnosis Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). Elsevier 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/282673/1/tran_khan%20bao.pdf Tran, Khanh Bao and Lang, Justin J. and Compton, Kelly and Xu, Rixing and Acheson, Alistair R. and Henrikson, Hannah Jacqueline and Kocarnik, Jonathan M. and Penberthy, Louise and Aali, Amirali and Abbas, Qamar and Abbasi, Behzad and Abbasi-Kangevari, Mohsen and Abbasi-Kangevari, Zeinab and Abbastabar, Hedayat and Abdelmasseh, Michael and Abd-Elsalam, Sherief and Abdelwahab, Ahmed Abdelwahab and Abdoli, Gholamreza and Abdulkadir, Hanan Abdulkadir and Abedi, Aidin and Abegaz, Kedir Hussein and Abidi, Hassan and Aboagye, Richard Gyan and Abolhassani, Hassan and Absalan, Abdorrahim and Abtew, Yonas Derso and Abubaker Ali, Hiwa and Abu-Gharbieh, Eman and Achappa, Basavaprabhu (2022) The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 400 (10352). pp. 563-591. ISSN 0140-6736 https://pdf.sciencedirectassets.com/271074/1-s2.0-S0140673622X00342/1-s2.0-S0140673622014386/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEDwaCXVzLWVhc3QtMSJHMEUCIQDfwjgIaSA41dQWskVN6fQLykeEEzwenbhP0ka%2Bxyx%2BMgIgajdDiMJdeR4cO5x2aUovC3p6WwG0xSRzCCy8%2FEhGhjQqvAUIhP%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARAFGgwwNTkwMDM1NDY4NjUiDA3tnLCLyt2KkImYUyqQBX8jaOg26VZhJvNVUnNNIVlaEKDQo2TCWB8OFSYMAOvy3rl%2Bmyury7%2F9w9W4Ldw8vpkU0mDjszDB7y9lmjpiFF1nEX8w8ql9HYY%2BmaIQ%2FW%2FbvCOe3Mgn4Yk%2FqolJEXqGEUpr%2Fxbuca9iEcR5cofkjW7%2FRFlJ9GAYVuMTJgmhH%2BJNut68EMz%2FFGX6ljpkoKHpZ5WuneNn3ZJSsrOwn8dTksaiMEEJ3o6MA64UF3ItsUef7JDTLYDksPQvR02GNTucjtVLKX%2BsXkMXFpvqIY8JzqJAMMm%2FEoUWKGAclKIoeOddoyw5BwYo8kwNCuIh8f5GyKgaIYs4LBwCZH3kgyv6qVaV2JvK0E%2B8EdwyDs3sm%2BzmfZ5BvdrQWiAPZGWS10BCHCrg28gvwbwvshaw5q%2Fq7Sk9KQ58%2FWs096pz2uu%2FOmMDGqDElTGacelRjyF3Radj1zGHiO5842HYHlDJMb9gjU1KbPQRPibVhBCzb8UYlGfTpLqM1VZjJr1z%2FYNeE0pHMci8ZY%2Bx1KORwsLXEQNl5vnWRvhswTnCPUK3V%2BktiBTAkZUYdbGLr3fKx1DV5WibrKuYuHz9begykylLemcGTjJEjY9xBMGLhhnRp%2FUdGFbsscz8GX0Aar7609LmnsE0KtpsNqvIAZnLBTBiMmEqDzTOVo%2Bsnv%2BNCuND1lL8qPk8%2Fn4t4QR9JO5dGgdOThN1gBCpZZJXZx63fbkVXntarPQBZ%2BoYtoz67iYeGt7ox2zel3Eb7tyrsDkCix1glFWF1Mj7y4apZA3UCFKUSh16BigCJUBZ4Q5q%2BIEg%2Fuaq4wb34W%2Btx1ZitAOGcXy0cEQMsRFHaM0NzseHG%2B7luVuC60sTUYq6TjDqP3CifNFYWz0gMLGP1qoGOrEBhg%2BZECJ%2BdAyKGgB08GRDWqNBrtNK5Bfczzd%2FQv4wZ%2Fr5noKFhajwmjZ28f7RPu5liY812Jlhn274dK8iwA%2FoJByRJZQI1LuQemYcnQKBAApqruFHs2WWsZEorKBKLQ35CHUNPJkpmf3lgQDeB5iVdfKcJA7SaOKEsauUT7Mm3Fj6EokH3TkBXWRO5KAmxOmfo609Hn8n6bHuoc71RPm0DPpLnbB9gaSJGHFfiQJuIZ62&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20231116T042514Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY6X7KUXH3%2F20231116%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=be379b8be77df11f48e1d2dd122cbf5fce2ce2a786ea35408334e468e1ee6182&hash=59f033b10c63f2c70ab8fe2f31fb789256fa291a898f818c06b201f4700f5c15&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0140673622014386&tid=spdf-7375cca7-1dc5-4574-b34d-a401a7a078d8&sid=3f0537815e6600488039979908a08da667f8gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0f0757525504055c5259&rr=826cf80699c3a2fb&cc=id doi.org/10.1016/S0140-6736(22)01438-6 |
| spellingShingle | Cancer Diagnosis Tran, Khanh Bao Lang, Justin J. Compton, Kelly Xu, Rixing Acheson, Alistair R. Henrikson, Hannah Jacqueline Kocarnik, Jonathan M. Penberthy, Louise Aali, Amirali Abbas, Qamar Abbasi, Behzad Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abbastabar, Hedayat Abdelmasseh, Michael Abd-Elsalam, Sherief Abdelwahab, Ahmed Abdelwahab Abdoli, Gholamreza Abdulkadir, Hanan Abdulkadir Abedi, Aidin Abegaz, Kedir Hussein Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Absalan, Abdorrahim Abtew, Yonas Derso Abubaker Ali, Hiwa Abu-Gharbieh, Eman Achappa, Basavaprabhu The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 |
| title | The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_full | The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_fullStr | The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_full_unstemmed | The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_short | The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_sort | global burden of cancer attributable to risk factors 2010 19 a systematic analysis for the global burden of disease study 2019 |
| topic | Cancer Diagnosis |
| url | https://repository.ugm.ac.id/282673/1/tran_khan%20bao.pdf |
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