Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01
Background: Allopurinol is the most commonly used drug for the treatment of gout arthritis. However, the use of allopurinol is associated with severe cutaneous adverse reactions (SCARs) and life-threatening immune-mediated reactions that include Stevens–Johnson syndrome (SJS). SJS induced by allopur...
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| Format: | Article |
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Frontiers Media SA
2022
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| _version_ | 1797037606175768576 |
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| author | Ferdiana, Astri Fachiroh, Jajah Oktarina, Dyah Ayu Mira Irwanto, Astrid Mahendra, Caroline Febriana, Sri Awalia Soebono, Hardyanto |
| author_facet | Ferdiana, Astri Fachiroh, Jajah Oktarina, Dyah Ayu Mira Irwanto, Astrid Mahendra, Caroline Febriana, Sri Awalia Soebono, Hardyanto |
| author_sort | Ferdiana, Astri |
| collection | UGM |
| description | Background: Allopurinol is the most commonly used drug for the treatment of gout arthritis. However, the use of allopurinol is associated with severe cutaneous adverse reactions (SCARs) and life-threatening immune-mediated reactions that include Stevens–Johnson syndrome (SJS). SJS induced by allopurinol is strongly linked with the presence of HLA-B*58:01 in the Asian population. Such a study has not been conducted in Indonesia. We present two cases with clinical diagnosis of SJS. These patients had Javanese ethnicity, for which evidence on the genetic predisposition of allopurinol-induced SJS/TEN had not been established. Testing for the presence of the HLA-B∗58:01 allele was positive in both cases. Our case report confirms findings from studies in Asian countries that link HLA-B*58:01 and allopurinol-induced SJS/TEN. A larger study is needed to elicit evidence that the HLA-B*58:01 allele can potentially be used as a genetic marker for allopurinol-induced SCARs among different ethnicities in Indonesia. |
| first_indexed | 2024-03-14T00:05:53Z |
| format | Article |
| id | oai:generic.eprints.org:282833 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-14T00:05:53Z |
| publishDate | 2022 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2828332023-11-17T08:23:44Z https://repository.ugm.ac.id/282833/ Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01 Ferdiana, Astri Fachiroh, Jajah Oktarina, Dyah Ayu Mira Irwanto, Astrid Mahendra, Caroline Febriana, Sri Awalia Soebono, Hardyanto Dermatology Background: Allopurinol is the most commonly used drug for the treatment of gout arthritis. However, the use of allopurinol is associated with severe cutaneous adverse reactions (SCARs) and life-threatening immune-mediated reactions that include Stevens–Johnson syndrome (SJS). SJS induced by allopurinol is strongly linked with the presence of HLA-B*58:01 in the Asian population. Such a study has not been conducted in Indonesia. We present two cases with clinical diagnosis of SJS. These patients had Javanese ethnicity, for which evidence on the genetic predisposition of allopurinol-induced SJS/TEN had not been established. Testing for the presence of the HLA-B∗58:01 allele was positive in both cases. Our case report confirms findings from studies in Asian countries that link HLA-B*58:01 and allopurinol-induced SJS/TEN. A larger study is needed to elicit evidence that the HLA-B*58:01 allele can potentially be used as a genetic marker for allopurinol-induced SCARs among different ethnicities in Indonesia. Frontiers Media SA 2022-06-13 Article PeerReviewed Ferdiana, Astri and Fachiroh, Jajah and Oktarina, Dyah Ayu Mira and Irwanto, Astrid and Mahendra, Caroline and Febriana, Sri Awalia and Soebono, Hardyanto (2022) Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01. Frontiers Genetics, 13. pp. 1-6. https://www.ncbi.nlm.nih.gov/ 10.3389/fgene.2022.839154 |
| spellingShingle | Dermatology Ferdiana, Astri Fachiroh, Jajah Oktarina, Dyah Ayu Mira Irwanto, Astrid Mahendra, Caroline Febriana, Sri Awalia Soebono, Hardyanto Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01 |
| title | Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01 |
| title_full | Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01 |
| title_fullStr | Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01 |
| title_full_unstemmed | Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01 |
| title_short | Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01 |
| title_sort | allopurinol induced stevens johnson syndrome in javanese men with positive hla b 58 01 |
| topic | Dermatology |
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