The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro
Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Fisheries and Marine Universitas Airlangga
2022
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| Online Access: | https://repository.ugm.ac.id/283134/1/document.pdf |
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| author | Pujiyanto, Mahendra Afililla, Zhaza Maslachah, Lilik Widiyatno, Thomas Valentinus Koerniawan, Mochamad Donny Suyono, Eko Agus Budiman, Arief Siregar, Ulfah Juniarti Suwanti, Lucia Tri |
| author_facet | Pujiyanto, Mahendra Afililla, Zhaza Maslachah, Lilik Widiyatno, Thomas Valentinus Koerniawan, Mochamad Donny Suyono, Eko Agus Budiman, Arief Siregar, Ulfah Juniarti Suwanti, Lucia Tri |
| author_sort | Pujiyanto, Mahendra |
| collection | UGM |
| description | Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to this drug. Therefore, a study on polysaccharides from microalgae may be a potential as bioactive compound for anti-malaria. The aim of this study was to determine the effectiveness of the mixed microalgae polysaccharides as anti-malarial in vitro. Polysaccharides were extracted from three microalgae Spirulina sp., mixed microalgae Glagah and mixed microalgae East Java using the alkaline extraction method. The anti-malarial activity test refers to the concentration of polysaccharides used in calculating the IC50 value by probit analysis. The concentration of polysaccharides of the three microalgae used were 0; 0.01; 0.01, 1, 10 and 100 µg/mL. The results showed that the IC50 values of polysaccharides of Glagah, Spirulina sp. and East Java microalgae were 3.18 µg/mL, 5.43µg/ mL, and 9.87 µg/mL, respectively. In Conclusion, polysaccharides of Indonesian mixed microalgae can be promoted as anti-malarial. © 2022 Faculty of Fisheries and Marine Universitas Airlangga. |
| first_indexed | 2024-03-14T00:06:39Z |
| format | Article |
| id | oai:generic.eprints.org:283134 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:06:39Z |
| publishDate | 2022 |
| publisher | Faculty of Fisheries and Marine Universitas Airlangga |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2831342023-11-22T07:49:58Z https://repository.ugm.ac.id/283134/ The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro Pujiyanto, Mahendra Afililla, Zhaza Maslachah, Lilik Widiyatno, Thomas Valentinus Koerniawan, Mochamad Donny Suyono, Eko Agus Budiman, Arief Siregar, Ulfah Juniarti Suwanti, Lucia Tri Veterinary Medicine Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to this drug. Therefore, a study on polysaccharides from microalgae may be a potential as bioactive compound for anti-malaria. The aim of this study was to determine the effectiveness of the mixed microalgae polysaccharides as anti-malarial in vitro. Polysaccharides were extracted from three microalgae Spirulina sp., mixed microalgae Glagah and mixed microalgae East Java using the alkaline extraction method. The anti-malarial activity test refers to the concentration of polysaccharides used in calculating the IC50 value by probit analysis. The concentration of polysaccharides of the three microalgae used were 0; 0.01; 0.01, 1, 10 and 100 µg/mL. The results showed that the IC50 values of polysaccharides of Glagah, Spirulina sp. and East Java microalgae were 3.18 µg/mL, 5.43µg/ mL, and 9.87 µg/mL, respectively. In Conclusion, polysaccharides of Indonesian mixed microalgae can be promoted as anti-malarial. © 2022 Faculty of Fisheries and Marine Universitas Airlangga. Faculty of Fisheries and Marine Universitas Airlangga 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283134/1/document.pdf Pujiyanto, Mahendra and Afililla, Zhaza and Maslachah, Lilik and Widiyatno, Thomas Valentinus and Koerniawan, Mochamad Donny and Suyono, Eko Agus and Budiman, Arief and Siregar, Ulfah Juniarti and Suwanti, Lucia Tri (2022) The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro. Jurnal Ilmiah Perikanan dan Kelautan, 14 (2). 396 – 403. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137035593&doi=10.20473%2fjipk.v14i2.34766&partnerID=40&md5=d1d6721c12f62d6bc0210f1501594078 10.20473/jipk.v14i2.34766 |
| spellingShingle | Veterinary Medicine Pujiyanto, Mahendra Afililla, Zhaza Maslachah, Lilik Widiyatno, Thomas Valentinus Koerniawan, Mochamad Donny Suyono, Eko Agus Budiman, Arief Siregar, Ulfah Juniarti Suwanti, Lucia Tri The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro |
| title | The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro |
| title_full | The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro |
| title_fullStr | The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro |
| title_full_unstemmed | The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro |
| title_short | The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro |
| title_sort | activity of mixed microalgae polysaccharides from indonesia as anti malaria in vitro |
| topic | Veterinary Medicine |
| url | https://repository.ugm.ac.id/283134/1/document.pdf |
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