The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers
Ten ethnomedicinal plant extracts from East Kalimantan flora, traditionally used to treat blood sugar levels and other diabetes-related diseases, were examined in vitro for their antidiabetic and free radical scavenging activities by inhibiting rat alpha-glucosidase and several free radicals such as...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Society for Indonesian Biodiversity
2022
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| Online Access: | https://repository.ugm.ac.id/283266/1/10615-Article%20Text-1050719-1-10-20220414.pdf |
| _version_ | 1826050615519739904 |
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| author | Ramadhan, Rico Phuwapraisirisan, Preecha Amirta, Rudianto Darmawan, Muhammad Fadil Bagas Ul-Haq, Kautsar Kusuma, Irawan Wijaya Suwito, Hery Abdulgani, Nurlita Mukhdlor, Ahmad Saparwadi, Saparwadi |
| author_facet | Ramadhan, Rico Phuwapraisirisan, Preecha Amirta, Rudianto Darmawan, Muhammad Fadil Bagas Ul-Haq, Kautsar Kusuma, Irawan Wijaya Suwito, Hery Abdulgani, Nurlita Mukhdlor, Ahmad Saparwadi, Saparwadi |
| author_sort | Ramadhan, Rico |
| collection | UGM |
| description | Ten ethnomedicinal plant extracts from East Kalimantan flora, traditionally used to treat blood sugar levels and other diabetes-related diseases, were examined in vitro for their antidiabetic and free radical scavenging activities by inhibiting rat alpha-glucosidase and several free radicals such as DPPH, ABTS, and Nitric oxide respectively. Out of the ten plant species investigated for their antidiabetic activity against maltase and sucrase rat alpha-glucosidase, three exhibited the strongest α-glucosidase inhibitory activity with maltose as a substrate, namely extracts of Garcinia nervosa, Syzygium caudatilimbum, and Shorea balangeran with IC50 values of 0.046; 0.037; 0.045 mg/mL. Meanwhile, quercetin as a positive control appeared to have a comparable IC50 value. Furthermore, among the ten extracts, Syzygium caudatilimbum, Shorea balangeran, and Ixora javanica showed good inhibition against sucrase rat alpha-glucosidase. Moreover, the antioxidant test showed that the ten methanol extracts of plants from East Kalimantan have an antioxidant activity indicated by IC50 values. The present study confirms that the ethnopharmacological use of selected plants from East Kalimantan might have potential as an antidiabetic and natural antioxidant. © 2022, Society for Indonesian Biodiversity. All rights reserved. |
| first_indexed | 2024-03-14T00:07:23Z |
| format | Article |
| id | oai:generic.eprints.org:283266 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:07:23Z |
| publishDate | 2022 |
| publisher | Society for Indonesian Biodiversity |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2832662023-11-21T06:17:06Z https://repository.ugm.ac.id/283266/ The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers Ramadhan, Rico Phuwapraisirisan, Preecha Amirta, Rudianto Darmawan, Muhammad Fadil Bagas Ul-Haq, Kautsar Kusuma, Irawan Wijaya Suwito, Hery Abdulgani, Nurlita Mukhdlor, Ahmad Saparwadi, Saparwadi Forestry Management and Environment Agricultural Land Management Forestry Sciences Ten ethnomedicinal plant extracts from East Kalimantan flora, traditionally used to treat blood sugar levels and other diabetes-related diseases, were examined in vitro for their antidiabetic and free radical scavenging activities by inhibiting rat alpha-glucosidase and several free radicals such as DPPH, ABTS, and Nitric oxide respectively. Out of the ten plant species investigated for their antidiabetic activity against maltase and sucrase rat alpha-glucosidase, three exhibited the strongest α-glucosidase inhibitory activity with maltose as a substrate, namely extracts of Garcinia nervosa, Syzygium caudatilimbum, and Shorea balangeran with IC50 values of 0.046; 0.037; 0.045 mg/mL. Meanwhile, quercetin as a positive control appeared to have a comparable IC50 value. Furthermore, among the ten extracts, Syzygium caudatilimbum, Shorea balangeran, and Ixora javanica showed good inhibition against sucrase rat alpha-glucosidase. Moreover, the antioxidant test showed that the ten methanol extracts of plants from East Kalimantan have an antioxidant activity indicated by IC50 values. The present study confirms that the ethnopharmacological use of selected plants from East Kalimantan might have potential as an antidiabetic and natural antioxidant. © 2022, Society for Indonesian Biodiversity. All rights reserved. Society for Indonesian Biodiversity 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283266/1/10615-Article%20Text-1050719-1-10-20220414.pdf Ramadhan, Rico and Phuwapraisirisan, Preecha and Amirta, Rudianto and Darmawan, Muhammad Fadil Bagas and Ul-Haq, Kautsar and Kusuma, Irawan Wijaya and Suwito, Hery and Abdulgani, Nurlita and Mukhdlor, Ahmad and Saparwadi, Saparwadi (2022) The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers. Biodiversitas, 23 (4). 2225 – 2230. ISSN 1412-033X https://smujo.id/biodiv/article/view/10615 https://doi.org/10.13057/biodiv/d230458 |
| spellingShingle | Forestry Management and Environment Agricultural Land Management Forestry Sciences Ramadhan, Rico Phuwapraisirisan, Preecha Amirta, Rudianto Darmawan, Muhammad Fadil Bagas Ul-Haq, Kautsar Kusuma, Irawan Wijaya Suwito, Hery Abdulgani, Nurlita Mukhdlor, Ahmad Saparwadi, Saparwadi The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers |
| title | The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers |
| title_full | The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers |
| title_fullStr | The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers |
| title_full_unstemmed | The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers |
| title_short | The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers |
| title_sort | potency of selected ethnomedicinal plants from east kalimantan indonesia as antidiabetic agents and free radical scavengers |
| topic | Forestry Management and Environment Agricultural Land Management Forestry Sciences |
| url | https://repository.ugm.ac.id/283266/1/10615-Article%20Text-1050719-1-10-20220414.pdf |
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