Predictors of mortality in immunocompromised children with respiratory infections
Background Respiratory infection is a common morbidity and a major cause of mortality in immunocompromised children. Hence, identification of clinical parameters that predict mortality among immunocompromised children with respiratory infections is of importance to provide timely and appropriate int...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2022
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| Online Access: | https://repository.ugm.ac.id/283290/1/35.pdf |
| _version_ | 1826050619969896448 |
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| author | Sutrisna, Lea Triasih, Rina Laksanawati, Ida Safitri |
| author_facet | Sutrisna, Lea Triasih, Rina Laksanawati, Ida Safitri |
| author_sort | Sutrisna, Lea |
| collection | UGM |
| description | Background Respiratory infection is a common morbidity and a major cause of mortality in immunocompromised children. Hence, identification of clinical parameters that predict mortality among immunocompromised children with respiratory infections is of importance to provide timely and appropriate intervention. Objective To determine predictors of mortality in immunocompromised children with respiratory infections. Methods We conducted a prospective cohort study of immunocompromised children aged 18 years or younger with respiratory tract infections who were admitted to Dr. Sardjito Hospital, Yogyakarta, Indonesia. All eligible children were prospectively followed up until hospital discharge. Clinical and laboratory parameters during the first 24 hours of hospitalization were collected. Results Of 79 eligible children, the overall mortality was 11 subjects (13.9). Fever, tachycardia, tachypnea, cyanosis, leukopenia, neutropenia, thrombocytopenia, and pleural effusion were predictive factors of mortality in bivariate analysis (P<0.25). A logistic regression model showed that neutropenia (absolute neutrophil count <125/mm3) and tachycardia were the best independent predictors of mortality in immunocompromised children with respiratory infections. The children with tachycardia had 15.8 times higher probability of mortality (95CI 5.0 to 4.4) and those with neutropenia had 8.24 times higher probability of mortality. Cyanosis and pleural effusion were also independent mortality predictors. Conclusion The risk of mortality is significantly increased in immunocompromised children with respiratory infection when tachycardia and neutropenia are also present. Paediatr Indones. 2022;62:237-42 DOI: 10.14238/pi62.4.2022.237-42. © 2022, Indonesian Pediatric Society Publishing House. All rights reserved. |
| first_indexed | 2024-03-14T00:07:27Z |
| format | Article |
| id | oai:generic.eprints.org:283290 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:07:27Z |
| publishDate | 2022 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2832902023-11-21T05:38:48Z https://repository.ugm.ac.id/283290/ Predictors of mortality in immunocompromised children with respiratory infections Sutrisna, Lea Triasih, Rina Laksanawati, Ida Safitri Respiratory Diseases Background Respiratory infection is a common morbidity and a major cause of mortality in immunocompromised children. Hence, identification of clinical parameters that predict mortality among immunocompromised children with respiratory infections is of importance to provide timely and appropriate intervention. Objective To determine predictors of mortality in immunocompromised children with respiratory infections. Methods We conducted a prospective cohort study of immunocompromised children aged 18 years or younger with respiratory tract infections who were admitted to Dr. Sardjito Hospital, Yogyakarta, Indonesia. All eligible children were prospectively followed up until hospital discharge. Clinical and laboratory parameters during the first 24 hours of hospitalization were collected. Results Of 79 eligible children, the overall mortality was 11 subjects (13.9). Fever, tachycardia, tachypnea, cyanosis, leukopenia, neutropenia, thrombocytopenia, and pleural effusion were predictive factors of mortality in bivariate analysis (P<0.25). A logistic regression model showed that neutropenia (absolute neutrophil count <125/mm3) and tachycardia were the best independent predictors of mortality in immunocompromised children with respiratory infections. The children with tachycardia had 15.8 times higher probability of mortality (95CI 5.0 to 4.4) and those with neutropenia had 8.24 times higher probability of mortality. Cyanosis and pleural effusion were also independent mortality predictors. Conclusion The risk of mortality is significantly increased in immunocompromised children with respiratory infection when tachycardia and neutropenia are also present. Paediatr Indones. 2022;62:237-42 DOI: 10.14238/pi62.4.2022.237-42. © 2022, Indonesian Pediatric Society Publishing House. All rights reserved. Indonesian Pediatric Society Publishing House 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283290/1/35.pdf Sutrisna, Lea and Triasih, Rina and Laksanawati, Ida Safitri (2022) Predictors of mortality in immunocompromised children with respiratory infections. Paediatrica Indonesiana(Paediatrica Indonesiana), 62 (4). 237 -242. ISSN 2338-466X https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138088875&doi=10.14238%2fpi62.4.2022.237-42&partnerID=40&md5=7892abbb19efc929ba3c960a81204e5b 10.14238/pi62.4.2022.237-42 |
| spellingShingle | Respiratory Diseases Sutrisna, Lea Triasih, Rina Laksanawati, Ida Safitri Predictors of mortality in immunocompromised children with respiratory infections |
| title | Predictors of mortality in immunocompromised children with respiratory infections |
| title_full | Predictors of mortality in immunocompromised children with respiratory infections |
| title_fullStr | Predictors of mortality in immunocompromised children with respiratory infections |
| title_full_unstemmed | Predictors of mortality in immunocompromised children with respiratory infections |
| title_short | Predictors of mortality in immunocompromised children with respiratory infections |
| title_sort | predictors of mortality in immunocompromised children with respiratory infections |
| topic | Respiratory Diseases |
| url | https://repository.ugm.ac.id/283290/1/35.pdf |
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