Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli
Controlling the premature release of hydrophobic drugs like quercetin over physiological conditions remains a challenge motivating the development of smart and responsive drug carriers in recent years. This present work reported a surface modification of mesoporous silica nanoparticles (MSN) by a fu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Research
2022
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| Online Access: | https://repository.ugm.ac.id/283323/1/60_Organically%20surface%20engineered%20mesoporous%20silica%20nanoparticles%20control%20the%20release%20of%20quercetin%20by%20pH%20stimuli.pdf |
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| author | Saputra, Ozi Adi Lestari, Windy Ayu Kurniansyah, Viardi Lestari, Witri Wahyu Sugiura, Takashi Mukti, Rino R. Martien, Ronny Wibowo, Fajar Rakhman |
| author_facet | Saputra, Ozi Adi Lestari, Windy Ayu Kurniansyah, Viardi Lestari, Witri Wahyu Sugiura, Takashi Mukti, Rino R. Martien, Ronny Wibowo, Fajar Rakhman |
| author_sort | Saputra, Ozi Adi |
| collection | UGM |
| description | Controlling the premature release of hydrophobic drugs like quercetin over physiological conditions remains a challenge motivating the development of smart and responsive drug carriers in recent years. This present work reported a surface modification of mesoporous silica nanoparticles (MSN) by a functional compound having both amines (as a positively charged group) and carboxylic (negatively charged group), namely 4-((2-aminoethyl)amino)-4-oxobut-2-enoic acid (AmEA) prepared via simple mechanochemistry approach. The impact of MSN surface modification on physical, textural, and morphological features was evaluated by TGA, N2 adsorption–desorption, PSA-zeta, SEM, and TEM. The BET surface area of AmEA-modified MSN (MSN-AmEA) was found to be 858.41 m2 g−1 with a pore size of 2.69 nm which could accommodate a high concentration of quercetin 118 higher than MSN. In addition, the colloidal stability of MSN-AmEA was greatly improved as indicated by high zeta potential especially at pH 4 compared to MSN. In contrast to MSN, MSN-AmEA has better in controlling quercetin release triggered by pH, thanks to the presence of the functional groups that have a pose-sensitive interaction hence it may fully control the quercetin release, as elaborated by the DFT study. Therefore, the controlled release of quercetin over MSN-AmEA verified its capability of acting as a smart drug delivery system. © 2022, The Author(s). |
| first_indexed | 2024-03-14T00:07:33Z |
| format | Article |
| id | oai:generic.eprints.org:283323 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-14T00:07:33Z |
| publishDate | 2022 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oai:generic.eprints.org:2833232023-11-20T06:09:59Z https://repository.ugm.ac.id/283323/ Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli Saputra, Ozi Adi Lestari, Windy Ayu Kurniansyah, Viardi Lestari, Witri Wahyu Sugiura, Takashi Mukti, Rino R. Martien, Ronny Wibowo, Fajar Rakhman Analytical Chemistry Controlling the premature release of hydrophobic drugs like quercetin over physiological conditions remains a challenge motivating the development of smart and responsive drug carriers in recent years. This present work reported a surface modification of mesoporous silica nanoparticles (MSN) by a functional compound having both amines (as a positively charged group) and carboxylic (negatively charged group), namely 4-((2-aminoethyl)amino)-4-oxobut-2-enoic acid (AmEA) prepared via simple mechanochemistry approach. The impact of MSN surface modification on physical, textural, and morphological features was evaluated by TGA, N2 adsorption–desorption, PSA-zeta, SEM, and TEM. The BET surface area of AmEA-modified MSN (MSN-AmEA) was found to be 858.41 m2 g−1 with a pore size of 2.69 nm which could accommodate a high concentration of quercetin 118 higher than MSN. In addition, the colloidal stability of MSN-AmEA was greatly improved as indicated by high zeta potential especially at pH 4 compared to MSN. In contrast to MSN, MSN-AmEA has better in controlling quercetin release triggered by pH, thanks to the presence of the functional groups that have a pose-sensitive interaction hence it may fully control the quercetin release, as elaborated by the DFT study. Therefore, the controlled release of quercetin over MSN-AmEA verified its capability of acting as a smart drug delivery system. © 2022, The Author(s). Nature Research 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283323/1/60_Organically%20surface%20engineered%20mesoporous%20silica%20nanoparticles%20control%20the%20release%20of%20quercetin%20by%20pH%20stimuli.pdf Saputra, Ozi Adi and Lestari, Windy Ayu and Kurniansyah, Viardi and Lestari, Witri Wahyu and Sugiura, Takashi and Mukti, Rino R. and Martien, Ronny and Wibowo, Fajar Rakhman (2022) Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli. Scientific Reports, 12 (1). ISSN 20452322 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85143055092&doi=10.1038%2fs41598-022-25095-4&partnerID=40&md5=48978461e4d9391af238b639f79e4eac |
| spellingShingle | Analytical Chemistry Saputra, Ozi Adi Lestari, Windy Ayu Kurniansyah, Viardi Lestari, Witri Wahyu Sugiura, Takashi Mukti, Rino R. Martien, Ronny Wibowo, Fajar Rakhman Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli |
| title | Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli |
| title_full | Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli |
| title_fullStr | Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli |
| title_full_unstemmed | Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli |
| title_short | Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli |
| title_sort | organically surface engineered mesoporous silica nanoparticles control the release of quercetin by ph stimuli |
| topic | Analytical Chemistry |
| url | https://repository.ugm.ac.id/283323/1/60_Organically%20surface%20engineered%20mesoporous%20silica%20nanoparticles%20control%20the%20release%20of%20quercetin%20by%20pH%20stimuli.pdf |
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